炉甘石混悬剂处方筛选

炉甘石混悬剂处方筛选 实验一项目名称:炉甘石混悬剂处方筛选 预习内容: 1.以炉甘石，氧化锌，甘油，羧甲基纤维素钠，西黄蓍胶，三氯化铝，枸橼酸钠，蒸馏水等为原料，拟定5个炉甘石处方，写明制备方法和质量评定方法 2.查明处方中各成分的作用 混悬剂(suspensions)系指难溶性固体药物以微粒状态分散于分散介质中形成的非均匀的液体制剂。混悬剂中药物微粒一般在0.5,10μm之间，小者可为0.1μm,大者可达50μm 或更大。混悬剂属于热力学不稳定的粗分散体系，所用分散介质大多数为水，也可用植物油。 Million. Water quality standards the dredging of river boundary section obtained provincial environmental protection Office special bonuses for wetland construction ... ... Million. But sober see, these achievements were made in the case of decreased rainfall for two consecutive years, we realize that environmental protection work still faced many problems in our County. Mainly in the PM2.5 and PM10 air quality monitoring indicators often exceeding, dredging of river section's water quality is not stable, and rural non-point source pollution has not been radical, Wade through the corporate environmental risk, livestock pollution rebound from severe, a wealth of protection and use of water resources is not well. If this year's rainfall, these problems will be exposed, and raw materials caused a great deal of pressure to go green. To solve these problems, we focused on three aspects of the work of environmental protection: (a) in accordance with the ... ... Real good green. According to the "Garden City, roads, tree-lined, mountain forests of" principle, to develop "governance focused piece, scale" afforestation programmes, and actively implement the barren hills green, River afforestation increased, City Green, farmland and other greening works to ensure complete afforestation this year ... ... Acres and acres and afforestation in the plain ... ... Acres, new nursery wood ... ... MU. Million. Water quality standards the dredging of river boundary section obtained provincial environmental protection Office special bonuses for wetland construction ... ... Million. But sober see, these achievements were made in the case of decreased rainfall for two consecutive years, we realize that environmental protection work still faced many problems in our County. Mainly in the PM2.5 and PM10 air quality monitoring indicators often exceeding, dredging of river section's water quality is not stable, and rural non-point source pollution has not been radical, Wade through the corporate environmental risk, livestock pollution rebound from severe, a wealth of protection and use of water resources is not well. If this year's rainfall, these problems will be exposed, and raw materials caused a great deal of pressure to go green. To solve these problems, we focused on three aspects of the work of environmental protection: (a) in accordance with the ... ... Real good green. According to the "Garden City, roads, tree-lined, mountain forests of" principle, to develop "governance focused piece, scale" afforestation programmes, and actively implement the barren hills green, River afforestation increased, City Green, farmland and other greening works to ensure complete afforestation this year ... ... Acres and acres and afforestation in the plain ... ... Acres, new nursery wood ... ... MU. 处方一 处方二 处方三 炉甘石 3.0g 3.0g 3.0g 氧化锌 1.5g 1.5g 1.5g 甘油 1.5g 1.5g 1.5g 羧甲基纤维素钠 0.15g 聚山梨酯80 0.6g 蒸馏水 加至 30ml 30ml 30ml 2.1.2 制法 1(制备稳定剂 ?称取羧甲基纤维素钠0.15 g，加约20ml蒸馏水，加热溶解成胶浆。 ? 称取聚山梨脂80 0.6 g，配成100g/L的水溶液备用。 Million. Water quality standards the dredging of river boundary section obtained provincial environmental protection Office special bonuses for wetland construction ... ... Million. But sober see, these achievements were made in the case of decreased rainfall for two consecutive years, we realize that environmental protection work still faced many problems in our County. Mainly in the PM2.5 and PM10 air quality monitoring indicators often exceeding, dredging of river section's water quality is not stable, and rural non-point source pollution has not been radical, Wade through the corporate environmental risk, livestock pollution rebound from severe, a wealth of protection and use of water resources is not well. If this year's rainfall, these problems will be exposed, and raw materials caused a great deal of pressure to go green. To solve these problems, we focused on three aspects of the work of environmental protection: (a) in accordance with the ... ... Real good green. According to the "Garden City, roads, tree-lined, mountain forests of" principle, to develop "governance focused piece, scale" afforestation programmes, and actively implement the barren hills green, River afforestation increased, City Green, farmland and other greening works to ensure complete afforestation this year ... ... Acres and acres and afforestation in the plain ... ... Acres, new nursery wood ... ... MU. 2(制备混悬剂 上述的三个处方，均采用加液研磨法制备，称取过100目筛的炉甘石、氧化锌于乳钵中，加炉甘石研磨至糊状后，再加入处方中的其他成分，最后加水至全量，搅匀即得。 炉甘 石含有适量 ( 0(5,- 1,质 量分 数 ) 氧化铁 ( 着色 剂 ) 的碱 式碳 酸锌 或氧 化锌 ， 略带 微 红色 ， 炉甘石 和氧化锌为 亲水性 药物 ，可被水 湿润 ，加适量 的分散剂 研磨 成糊 状 ，使 其 分散 ， 用前 应和氧化锌 混合过 120 目筛 。 简 单搅拌不 易 制得 均匀 细腻产品 ， 颗粒易沉降。 在制 备时至少研磨30m in或使 用胶体磨才能保证制剂 的质量 。该制 剂是一种混悬 剂 ， 如配制方法 不 当或 选用 的助悬 剂不适 宜 ，不 易 保 持 混悬状 态 ， 且涂 用时有砂砾 感 。 久贮沉 淀的颗粒易 聚结 ，振摇亦 难再分散 。在炉 甘石洗剂 的处方 中 ，使用反絮凝 剂枸 橼酸钠 、润湿剂 甘油 、吐温 -80 、助悬 剂 羧 甲 基纤 维素等 ， 可提高制剂 的稳定性 和质量 。 自然界中许多有机药物存在多晶型，如无味氯霉素就有4种晶型(A、B、C与无定型)。多晶型药物制备混悬剂时，由于外界因素影响，特别是温度的变化，可加速晶型之间的转化 如由溶解度大的亚稳定型转化成溶解度较小的稳定型，导致混悬剂中析出大颗粒沉淀，并可能降低疗效。因此，在制备混悬剂时，不仅要考虑微粒的粒径，还应考虑其粒度分布，其分布范围愈窄愈好;向混悬剂中加入适量的亲水胶(如阿拉伯胶、甲基纤维素等)或表面活性剂(如聚山梨酯80等)，能够延缓或防止微粒增大。 甘油 可增加分散介质的粘度，也可增加微粒的亲水性。甘油多用于外用制剂，亲水性药物的混悬剂可少加，对疏水性药物应酌情多加。 西黄蓍胶 用量为0.5%~1%，稳定的pH值为4~7.5。本品水溶液为假塑性流体，粘度大，是一种既可内服也可外用的助悬剂。 羧甲基纤维素钠(CMC-Na) 用量多为1%，稳定的pH值为5~10。本品是阴离子化合物，因此与多价阳离子如三氯化铁、硫酸铝等不能配伍。 混悬剂的质量评定 1沉降体积比的测定 Million. Water quality standards the dredging of river boundary section obtained provincial environmental protection Office special bonuses for wetland construction ... ... Million. But sober see, these achievements were made in the case of decreased rainfall for two consecutive years, we realize that environmental protection work still faced many problems in our County. Mainly in the PM2.5 and PM10 air quality monitoring indicators often exceeding, dredging of river section's water quality is not stable, and rural non-point source pollution has not been radical, Wade through the corporate environmental risk, livestock pollution rebound from severe, a wealth of protection and use of water resources is not well. If this year's rainfall, these problems will be exposed, and raw materials caused a great deal of pressure to go green. To solve these problems, we focused on three aspects of the work of environmental protection: (a) in accordance with the ... ... Real good green. According to the "Garden City, roads, tree-lined, mountain forests of" principle, to develop "governance focused piece, scale" afforestation programmes, and actively implement the barren hills green, River afforestation increased, City Green, farmland and other greening works to ensure complete afforestation this year ... ... Acres and acres and afforestation in the plain ... ... Acres, new nursery wood ... ... MU. 将配制好的炉甘石洗剂置15ml具塞量筒中，密塞，放置一段时间，再振摇1分钟，倒置 翻转(一反一正为一次)，记录筒底的沉降物分散完全时的高度。 记录混悬液的初始高 度Ho，再分别将放置5、10、15、20、25、30分钟的降物高度H记录于表1中。按式: 沉降体积比F=H/Ho ，计算各个放置时间的沉降体积比。记入表1中。以沉降容积比F= (H/Ho)为纵坐标，时间t为横坐标，绘制沉降曲线图，沉降体积比在0~1之间，其数值 越大，混悬剂越稳定。 Million. Water quality standards the dredging of river boundary section obtained provincial environmental protection Office special bonuses for wetland construction ... ... Million. But sober see, these achievements were made in the case of decreased rainfall for two consecutive years, we realize that environmental protection work still faced many problems in our County. Mainly in the PM2.5 and PM10 air quality monitoring indicators often exceeding, dredging of river section's water quality is not stable, and rural non-point source pollution has not been radical, Wade through the corporate environmental risk, livestock pollution rebound from severe, a wealth of protection and use of water resources is not well. If this year's rainfall, these problems will be exposed, and raw materials caused a great deal of pressure to go green. To solve these problems, we focused on three aspects of the work of environmental protection: (a) in accordance with the ... ... Real good green. According to the "Garden City, roads, tree-lined, mountain forests of" principle, to develop "governance focused piece, scale" afforestation programmes, and actively implement the barren hills green, River afforestation increased, City Green, farmland and other greening works to ensure complete afforestation this year ... ... Acres and acres and afforestation in the plain ... ... Acres, new nursery wood ... ... MU.