钳刮术前应用卡孕栓扩张宫颈32例临床分析

钳刮术前应用卡孕栓扩张宫颈32例临床 钳刮术前应用卡孕栓扩张宫颈32例临床分 析 252吉林大学学报(医学版)2002年第28卷第3期 组织有HSP90的广泛达,但在癫瘸发作1h, 8d,脑组织HsPg0的表达没有变化.认为HSP90 对脑组织应激损伤没有保护作用].本研究发现, HSP90在正常大鼠耳蜗螺旋神经节神经元,Cod氏 器和血管纹均有较强的表达,但耳聋组表达未见有 效增加.因而本文作者认为HsPg0对内耳损伤没有 保护作用. 综上所述HSPs是内耳损伤的有效保护因子. HSPs虽然是科研领域内所熟知的对象,但其在内 耳的作用还有待深入研究. [参考文献] [1]伍雁.僚有栓.HSP和蛋白术解酶与生物的应澈反应EJ3. 细胞生物学杂志.2000,22(1)8-13. [2]NamYJ,StoverT,HartmanSS,eta1.Upregu]atinnofglial cellline—derivedneurotrophlcfactor(GDNF)inthera【c0c}I1ea [oliowlngnoise[J].JHearRes,2000,146(i一2)}i-6 [33DetreJA.Cha~eB,MaecottaL.etn【.Cor~latianofdiffusion MRlandheatI10ckproteininarRtemboLicstrokgmodel[J]. JNeurolSd.1997.148(2):163—169. [43YuQ,KentCR,Tysel[M,eta1.Retinaluptakeofintraiilreal— lyin~ectedHsc/Hsp70anditseffecto11susceptibilitytolight damageEJ3.JMolVis,8001,7:48—56. [5]Zamosti~noR.PinhasovA.BassanM,eta1.A(emtomo[ar- actingneuroprotectivepeptideinducesincreasedlevels0fheat shockprotein60inratcorticalDeuro~|apotend~lneuropro— teedvemechanism[刀.JNeuro~~iLeft,1999,264:9-18. [63YamamotoM,FanL,Wa~yamaT,etal_Constitutiveexpres— sionofthe27000beat—shockproteininDeur~sandsatellite ceils|ntheperipheralfiefvouasystemoftherat[J].JAmt Rec,2001,262(2):213—220. [73GassP.PriorP,KiessLingM.Correlationbetweenseizurein— tensityand5tre日.proteinexpressionafterlimbicepilepsyin therRtbrainEJ3.JNeuroselence.1995P65(1);27-36. ThesignificanceofHSPsexpressionincochleaofratswith deafnessinducedbydrugtoxification NIUChun_b0.JINGLing,DUBao-dang,LIUXIn-mei,LIUShu-fang (Dept.o/Otolaryngology,TheFirstHospital,JUinUniversity?Changchun130021?China) [Abstract]Objective:ToinvestigatetheexpressionoffourHSPsincochleaofratswithdeafnessandto determinetheireffectandsignificanceinthehearinglossandrecovery.Methods:Deafnessmodelofrat wasestablishedbyintraperltonealinjectionofsulfategentamycine.Cochleasembeddedinparaffinwere dissected.TheexpressionofHSPswasdetectedbyimmunohistochemlstrySP.Results:ThefourHSPs hadbeenstainedinthecochlear,especiallyintheorganofCorti,striavaseularis,andspiralligand.The generalcharacteristicsofdeafratswasthesameasnorrfialrats,however,expressionofHSPT0,HSP60. andHSP27weresignificantlyenhanced.respectively,whereasHSP90changednothing.Conclusion:HSPs areselectivelyexpressedinratscochlea.andHSPT0HSP60andHSP27involedinthemechanismofdeaf. nessmayplayaimportantroleintherecovery. [Keywords~heatshockprotein(HSP);cochlea;deafness 钳刮术前应用卡孕栓扩张宫颈32例临床分析 武警吉林省总队医院妇产科关永红孙兴梅谭志敏 2000年1,lo月本院门诊对32例孕10~14周妊娠者术前用卡孕栓进行宫颈扩张,效果满意. 1临床资科?一般资料:本组32倒为本院门诊病人,经询问病史,尿HCG(+),查子宫大小确诊 为妊娠lO,14周,其 中初产妇l2倒,经产妇2O倒(包括剖宫产6例).?用药方法采用东北制药总厂生产的卡孕拴 1枚(1rag),于术前2h放置 阴道后穹窿,初产妇中有1例用药2mg.其余均用药1mg.@疗效判定;显效,宫口扩张1.0, 1.5cm;有效,宫口扩张0.5, 1.Ocm}无效.宫口无扩张.?结果:2h后.初产妇l2倒中宫口扩张1.5cm为7例,1.0cm为6例; 经产妇2O例.宫口扩张 1.5cm为14例,1.0cm为6倒,有效率达100,手术操作顺利,钳夹胎儿,胎盘无阻力,无一例发生 并发症. 2讨论由于各种原因失去早期人工流产机会的孕妇,常需施用钳刮术来中止妊娠,但因孕 10~14周妊娠胎儿,胎盘 已形成,而且有时较大.给手术带来丁极大的难度和风硷,易发生宫颈损伤,子宫穿孔,出血,不 全流产荨并发症,解决这一难 题的关键是宫颈扩张.应用卡孕栓术前行富颈扩张,效果满意,为钳刮术提供了方便条件,值 得临床推广应用.