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A team of scientists and clinicians at UC San Francisco has discovered how to detect abnormal brain rhythms associated with Parkinson's by implanting electrodes within the brains of people with the disease. The work may lead to developing the next generation of
brain stimulation devices to alleviate(减轻,缓和) symptoms for people with the disease.
Described this week in the journal Proceedings of the National Academy of Sciences (PNAS), the work sheds light on how Parkinson's disease affects the brain, and is the first time anyone has been able to measure a quantitative signal from the disease within the cerebral cortex(大脑皮层) -- the outermost layers of the brain that helps govern memory, physical movement and consciousness.
"Normally the individual cells of the brain are functioning independently much of the time,
working together only for specific tasks," said neurosurgeon Philip Starr, MD, PhD, a professor of neurological surgery at UCSF and senior author of the paper. But in Parkinson's disease, he said, many brain cells display "excessive synchronization," firing together
inappropriately most of the time.
"They are locked into playing the same note as everyone else without exploring their own music," Starr explained. This excessive synchronization(同步,同时性) leads to movement
problems and other symptoms characteristic of the disease.
The new work also shows how deep brain stimulation (DBS), which electrifies regions deeper in the brain, below the cortex, can affect the cortex, itself. This discovery may
change how DBS is used to treat Parkinson's and other neurologically based movement disorders, and it may help refine the technique for other types of treatment.
在加州大学旧金山分校的科学家和临床医生的一个研究小组发现如何与帕金森氏症相关的疾病的人的大
脑内植入电极来检测异常的脑节律。这项工作可能导致开发下一代的脑刺激器缓解(减轻,缓和)的症
状与疾病的人。
在国家科学院的科学(PNAS)杂志上的论文中描述这个星期,工作流光帕金森氏症影响大脑如何,以及
是第一次有人已经能够测量大脑皮质内的一个定量的疾病信号(大脑皮层) -大脑的最外层,有助于治
理内存,物理运动和意识。
“通常情况下,个别脑细胞是独立运作的大部分时间,只对特定的任务一起工作,说:”神经外科医生菲
利普?斯塔尔博士,加州大学旧金山分校神经外科教授和资深作者的论文。但是,在帕金森氏病,他说,
许多脑细胞显示“过度同步,”炒在一起不适当的大部分时间。
“他们锁定到其他人一样没有探索自己的音乐播放相同的音符,”斯塔尔解释。这种过度的同步(同步,
同时性)导致的运动障碍等症状本病的特征。
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新的工作也表明,脑深部电刺激(DBS),通电区域在大脑深,皮质下,可以影响皮质本身。这一发现可能改变DBS用于治疗帕金森氏症和其他神经系统为基础的运动障碍,它可以帮助完善其他类型的治疗技术。
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