郑氏七厘散论文：郑氏七厘散 急性软组织损伤 血液流变学

郑氏七厘散：郑氏七厘散 急性软组织损伤 血液流变学 郑氏七厘散论文:郑氏七厘散 急性软组织损伤 血液流变学 【中文摘要】:采用我院已故著名武医专家郑怀贤教授的郑氏七厘散作为治疗药物,观察郑氏七厘散治疗大鼠急性软组织损伤的作用;探讨该中药方剂对急性软组织损伤血液流变学的影响,并为该药临床治疗急性软组织损伤提供理论依据。:72只两月龄SD雄性大鼠,体重212.5?32.2g,适应性喂养7天后采用打击法造模。按随机数字表法随机分三组(n=24),即A组:实验组(郑氏七厘散)、B组:药物对照组(《良方集腋》七厘散)、C组:空白对照组;分三组后再随机分为4个时相点组(n=6),即a组(第1天组)、b组(第3天组)、c组(第7天组)、d组(第10天组)。造模1小时后按照不同组别,分别给予中药、蒸馏水灌服,每天2次。在每个时相点观察局部造模区软组织损伤指数变化;取血标本检测血液流变学指标。将结果用SPSS 16.0软件进行数据处理。结果:(1)软组织损伤症候指数评分:造模后第7天开始郑氏七厘散组与空白对照组比较有显著差异(P0.05)。(2)血液流变学指标:在造模后第1天郑氏七厘散组、《良方集腋》七厘散组两组大鼠的血液流变学指标与空白对照组相比有所降低,但无显著性差异(P>0.05);郑氏七厘散组与《良方集腋》七厘散组无明显差异(P>0.05)。在造模后第3天郑氏七厘散组、《良方集腋》七厘散组两组大鼠的血液流变学指标与空白对照组比较,全血粘度、红细胞压积、红细胞聚集指数、红细胞刚性指数、全血 【英文摘要】: The rats were taken orally Zheng’s Qili-San of professor Zheng Huaixian, the late well-known martial arts and medical expert in our hospital, after the animal model to explore the effects of treatment and hemorheology on acute soft tissue injure, and to provide a theoretical basis for the clinical treatment.Methods: 72 SD male rats which were two-month-old and weighing 212.5?32.2g, were made into models by combating after fed adaptively. They were divided into three groups randomly (n=24), A: namely experimental group (Zheng’ s Qili-San); B: compared group (“LiangFangJiYe”Qili-San); C: controlled group. Then they were divided into four time point groups (n=6). That was group a (the first day group), group b (the third group), group c (the seventh day group), group d (the tenth day group). They were given Chinese traditional medicine and steamed water according to different groups after an hour modeling, twice a day. After observing at each time point and soft tissue modeling localized damage index. We processed the data and analyzed them by SPSS 1 group, but had no significant differences(P>0.05);and Zheng’s Qili-San group’s index compared with“LiangFangJiYe”Qili-San group’s had no significant differences(P>0.05). 3 days after modeling, Zheng’ s Qili-San group’s and“LiangFangJiYe”Qili-San group’s Whole blood viscosity, hematocrit, erythrocyte aggregation index, erythrocyte rigidity index, whole blood reduced viscosity were lower than those of Blank control group, there were significant differences (P 0.05); and Zheng’s Qili-San group’s index 6.0.Result: (1) Soft tissue injury symptoms index score: 7 days after modeling, Zheng’s Qili-San group started with the control group were significantly different (P 0.05). (2) hemorheology index:In the 1st day after modeling, Zheng’s Qili-San group’ s and“LiangFangJiYe”Qili-San group’s Whole blood viscosity, plasma viscosity, hematocrit, erythrocyte aggregation index, erythrocyte rigidity index, whole blood reduced viscosity were lower than those of Blank control compared with“LiangFangJiYe” Qili-San group’s had no significant differences (P>0.05). From the 7th day after modeling, Zheng’s Qili-San group’s and “LiangFangJiYe”Qili-San group’s whole indexes are lower than those of Blank control group, there were significant differences(P0.05).Conclusion: Zheng’s Qili-San has a clear therapeutic effect on rats with acute soft tissue injury. It can significantly improve the symptoms of the soft tissue injury in rats and blood hemorhelogy. Zheng’s Qili-San on the treatment of acute soft tissue injury has the same effects to“LiangFangJiYe”Qili-San. So it should be applied in clinical practice and spread in the field of Chinese traditional medicine. 【关键词】郑氏七厘散 急性软组织损伤 血液流变学 【采买】 1.3.9.9.38.8.4.8 1.3.8.1.13.7.2.1 同时提供论文写作定制和论文发表服务.保过包发. 【说明】本文仅为中国学术文献总库合作提供，无涉版权。作者如有异议请与总库或学校联系。 【英文关键词】Zheng’s Qili-San acute soft tissue injury hemorheology 【目录】郑氏七厘散对大鼠急性软组织损伤血液流变学影响的研究 摘要 4-6 Abstract 6-7 1 前言 10-11 2 文献综述 11-17 2.1 急性闭合性软组织损伤的病理学的变化 11 2.2 急性闭合性软组织损伤的病理生理学变化 11 2.3 祖国医学对血瘀证的认识 11-12 2.4 中医血瘀证与血液流变学的相关性 12-13 2.5 活血化瘀方药对血液流变学影响的研究 13-15 2.6 西医治疗急性软组织损伤的研究概况 15 2.7 中医治疗急性闭合性软组织损伤的研究概况 15-17 3 研究内容与方法 17-33 3.1 实验材料 17-18 3.1.1 实验动物 17 3.1.2 实验药物 17 3.1.3 主要实验仪器设备 17-18 3.1.4 主要试剂 18 3.2 实验方法 18-20 3.2.1 实验药物的制备 18-19 3.2.2 实验动物造模 19 3.2.3 实验动物分组 19 3.2.4 实验给药途径、剂量、方法 19-20 3.2.5 观察指标 20 3.3 统计学分析 20-21 3.4 实验结果 21-33 3.4.1 造模和样本量情况 21 3.4.2 大鼠体重情况 21 3.4.3 大鼠软组织损伤指数结果 21-22 3.4.4 各组大鼠血液流变学指标结果 22-33 4 分析与讨论 33-38 4.1 祖国医学对气滞血瘀的认识 33 4.2 气滞血瘀证动物模型的建立及评价 33-34 4.3 郑氏七厘散的组方特点及方药分析 34-36 4.4 郑氏七厘散对大鼠血液流变学的影响 36-37 4.5 郑氏七厘散阳性对照药的选择 37-38 5 结论 38-39 6 参考文献 39-43 7 附件 43-44 致谢 44