儿童医学中心推出一站式诊疗新模式
No.10张丽梅,等:内毒素休克大鼠肾组织TLR2mRNA和TLR4mRNA的表达l173?
TLR2mRNA和TLR4mRNA的表达有关.本实验为
GC和VIP临床应用于严重感染,减轻器官损伤提供
部分理论依据.
参考文献:
[1]OberholzerA,OberholzerC,MoldawerLL.Sepsissyndromes:under- standingtheroleofinnateandacquiredimmunity[J].Shock, 2001,16(2):83—89.
[2]HotchkissRS,NicholsonDW.Apoptosisandeaspasesregulatedeath andinflammationinsepsis[J].NatRevImmunol,2006,6(11): 8l3—822.
[3]AkiraS,TakedaK.T011-likereceptorsignalling[J].NatRev Immunol,2004,4(7):499—511.
[4]Gonzalez-ReyE,ChoruyA,DelgadoM.Regulationofimmune tolerancebyanti—inflammatoryneuropeptides[J]NatRevImmunol, 2007,7(1):52—63.
[5]FosterN,LeaSR,PreshawPM,eta1.Pivotaladvance:vasoactive intestinalpeptideinhibitsup—regulationofhumanmonocyteTLR2
andTLR4byLPSanddifferentiationofmonocytestomacrophages [J].JLeukocBiol,2007,81(4):893—903.
[6]GomarizRP,ArranzA,AbadC,eta1.Time-courseexpressionof Toll?likereceptors2and4ininflammatoryboweldiseaseandhomeo—
staticectofVIP[J].JLeukocBiol,2005,78(2):491—502.
[7]张育才,杨丽萍,汤定华,等.血管活性肠肽对大鼠内毒素性
休克肠道损伤保护作用的研究[J].中华儿科杂志,2006,44
(5):369—373.
[8]WisselH,SchulzC,KoehneP,eta1.Chlamydophilapneumoniae inducesexpressionoftoll—likereceptor4andreleaseofTNF-alpha
andMIP?-2viaanNF??kappaBpathwayinrattypeIIpneumocytes [i日[日[目
[J].RespirRes,2005,6:51.
[9]AkiraS,UematsuS,TakeuchiO.Pathogenrecognitionandinnate immunity[J].Cell,2006,124(4):783—801.
[10]KrutzikSR,OchoaMT,SielingPA,cta1.Activationandregulation ofToll-likereceptors2and1inhumanleprosy[J].NatMed, 2003,9(5):525—532.
[11]Kurt—JonesEA,PopovaL,KwinnL,eta1.Patternrecognition receptorsTLR4andCD14mediateresponsetorespiratorysyncytial virus[J].NatImmunol,2000,1(5):398—401.
[12]WolfsTG,BuurmanWA,vanSchadewijkA,eta1./nvivoexpres- sionofToll—likereceptor2and4byrenalepithelialcells:IFN—
gammaandTNF-alphamediatedup-regulationduringinflammation [J].JImmunol,2002,168(3):1286—1293.
[13]张德林,赵黄,祝胜关,等.体外循环时糖皮质激素对
CDI4单核细胞表面TLR2/4表达的影响[J].中华胸心血管
外科杂志,2006,22(4):239—241.
[14]TsuboiN,YoshikaiY,MatsuoS,eta1.Rolesoftoll—likereceptors
inC-Cchemokineproductionbyrenaltubularepithelialcells[J].J Immunol,2002,169(4):2026—2033.
[15]姚咏明,鄢小建,姚凤华,等.严重腹腔感染大鼠组织Toll样受
体2/4基因表达及其调节机制[J].中国危重病急救医学,
2003,15(11):646—650.
[16]JuarranzY,AbadC,MartinezC,eta1.Protectiveeffectofvasoac—
tiveintestinalpeptideonbonedestructioninthecollagen-induced arthritismodelofrheumatoidarthritis[J].ArthritisResTher,
2005,7(5):R1034一R1045.
[17]LiuPT,StengerS,LiH,eta1.Toll-likereceptortriggeringofa
vitaminDmediatedhumanantimicrobialresponse[J].Science,
2006,311(5768):1770—1773.
收稿日期:2009-02-13本文编辑:吴洋
:曰Ei[i=j品品[i已l二目E云[i[珂:i[iI__]曰r二[j目品[_[][j[_[] 儿童医学中心推出一站式诊疗新模式
在第9个世界心脏13之际,上海交通大学医学院附属上海儿童医学中心在国内率先推出小儿先天性
心脏病"一站式"诊疗新模式.这不仅使患者住院天数大大缩短,医疗费用明显降低,而且为"镶嵌式治
疗"(Hybrid)这一国际心脏病诊疗新技术的开展搭建更好的平台. 这一诊疗新模式近日引起新闻界的广泛关注,解放日报,人民网,中国新闻网,新民网,天天新报,上
海商报等多家媒体作了报道.
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