苯氧乙醇的性质、应用和合成

苯氧乙醇的性质、应用和合成 学院: 专业: 班级: 姓名: 学号: 时间: 成绩: 论 文 评 语 评阅教师签字: loan management (post) review: 1, approval criteria have been implemented; 2, the contract is correct; 3, in line with the contract, payment; 4, no other major cases against loan security;、Reviewed by: date of record form 9: qilu bank borrowing by single years of maximum amount a maximum no-loan borrowers: borrowers: ... Borrower name number, line of credit expiry date year month day to year month day maximum number of years in the loan contract are the top line opened, the borrowed and requested your bank opened credit lines above, is hereby requested. Borrower signature: date agreed to open credit lines. Customer Manager signature: date agreed to open credit lines. Loan review signature: date line cancellation-I did not use the loan amount, your bank credit lines to be cancelled. -Credit loan principal repayment, your bank credit lines to be cancelled. Borrower signature: date-unused credit lines, agree to write off loans. -Credit loan principal repayment, agree to write off loans. Customer Manager signature: date case, agree to write off loans. Loan review signature: date of record form 16: qilu self credit for credit card cancellation application form name of borrower ID number and credit limit expiration date year month day to year month day year contract number self-service card-I do not use credit, your bank credit lines to be cancelled. -Credit loan principal repayment, your bank credit lines to be cancelled. Borrower signature: date-unused credit lines, agree to write off loans. -Credit loan principal repayment, agree to write off loans. Customer Manager signature: 苯氧乙醇的性质、应用和合成 摘要:苯氧乙醇，别名乙二醇单苯醚，苯基溶纤剂，分子式:CHO,6102 结构式: OCHCHOH 22 苯氧乙醇是一种高沸点(低挥发溶剂。又是一种低致敏，高效(广 谱的防腐杀菌剂。由于它既能溶于水，又能溶于油中，所以近年来在 轻工，日化行业使用频度越来越高。国外对其应用研究甚多，尤其是 复合防腐剂中作为溶剂和协同剂，在很多产品中使用。我国在这方面 研究很少，为此研究它的合成、应用，很有现实意义和经济效益。 Phenoxy ethanol properties, preparation and application Abstract: phenoxyethanol, alias ethylene glycol monophenyl ether, phenyl cellosolve, molecular formula: CHO, structure type: 6102 OCHCHOH 22 Phenoxyethanol is a kind of high boiling point and low volatile solvents. It is a low sensitization, efficient broad-spectrum antiseptic. Because it can dissolve in water, and soluble in oil, so in recent years in light industry, chemical industry, more and more high use frequency. The application research of abroad very much, especially in preservative agent is used as a solvent and a synergistic agent, in many products used in. In our country it has rarely been studied, to study its synthesis, application, has very important practical significance and economic benefits. loan management (post) review: 1, approval criteria have been implemented; 2, the contract is correct; 3, in line with the contract, payment; 4, no other major cases against loan security;、Reviewed by: date of record form 9: qilu bank borrowing by single years of maximum amount a maximum no-loan borrowers: borrowers: ... Borrower name number, line of credit expiry date year month day to year month day maximum number of years in the loan contract are the top line opened, the borrowed and requested your bank opened credit lines above, is hereby requested. Borrower signature: date agreed to open credit lines. Customer Manager signature: date agreed to open credit lines. Loan review signature: date line cancellation-I did not use the loan amount, your bank credit lines to be cancelled. -Credit loan principal repayment, your bank credit lines to be cancelled. Borrower signature: date-unused credit lines, agree to write off loans. -Credit loan principal repayment, agree to write off loans. Customer Manager signature: date case, agree to write off loans. Loan review signature: date of record form 16: qilu self credit for credit card cancellation application form name of borrower ID number and credit limit expiration date year month day to year month day year contract number self-service card-I do not use credit, your bank credit lines to be cancelled. -Credit loan principal repayment, your bank credit lines to be cancelled. Borrower signature: date-unused credit lines, agree to write off loans. -Credit loan principal repayment, agree to write off loans. Customer Manager signature: 关键词:苯氧乙醇 威廉森合成法 有机合成 防腐剂 (一)苯氧乙醇的基本性质 苯氧乙醇，别名乙二醇单苯醚，苯基溶纤剂(2-Phenoxyethanol，Phenyl cellulose。Phenoxeto) ，常温下是油状液体，稍有芳香气味和收敛味。熔点14?，沸点244(9? ，闲点107? ，其溶解度和分配系数见: (二)苯氧乙醇的应用 1. 苯氧乙醇在医药上的应用: 苯氧乙醇也是一种重要的外科药物，常被用于皮肤的创伤、烧伤、烫伤等表面感染 以及脓肿、脓疮的治疗。可应用于医药防腐杀菌。在对于硬表面、消毒洗涤剂和外科医疗器械消毒剂的配方中，可与其他杀菌活性成分配合使用，增强其他抗菌剂的活性。 loan management (post) review: 1, approval criteria have been implemented; 2, the contract is correct; 3, in line with the contract, payment; 4, no other major cases against loan security;、Reviewed by: date of record form 9: qilu bank borrowing by single years of maximum amount a maximum no-loan borrowers: borrowers: ... Borrower name number, line of credit expiry date year month day to year month day maximum number of years in the loan contract are the top line opened, the borrowed and requested your bank opened credit lines above, is hereby requested. Borrower signature: date agreed to open credit lines. Customer Manager signature: date agreed to open credit lines. Loan review signature: date line cancellation-I did not use the loan amount, your bank credit lines to be cancelled. -Credit loan principal repayment, your bank credit lines to be cancelled. Borrower signature: date-unused credit lines, agree to write off loans. -Credit loan principal repayment, agree to write off loans. Customer Manager signature: date case, agree to write off loans. Loan review signature: date of record form 16: qilu self credit for credit card cancellation application form name of borrower ID number and credit limit expiration date year month day to year month day year contract number self-service card-I do not use credit, your bank credit lines to be cancelled. -Credit loan principal repayment, your bank credit lines to be cancelled. Borrower signature: date-unused credit lines, agree to write off loans. -Credit loan principal repayment, agree to write off loans. Customer Manager signature: 2. 苯氧乙醇的溶解性: 苯氧乙醇具很好的溶解性和混溶性，常作香料的稀释剂，对羟基苯甲酸酯类的理想溶剂(染发色料和指甲油色料的较佳溶剂和助渗透剂。油墨、圆珠笔油的溶剂和改良剂。印台油墨的渗透剂。 3. 苯氧乙醇在日常生活中的应用: 苯氧乙醇对绿脓肝菌有特效的抑菌性，对革兰氏阳性菌和阴性菌，都有抑菌作用 由于其在水中、白矿油、棕榈酸异丙酯等化妆品组分中，都有相当的溶解性。加之它的高效广谱、低毒(太鼠口服I =l 260 mCkg)和无过敏刺激性(2(2,水溶液对皮肤无刺激性)。因而被广泛地用于化妆品的膏霜和洗发香波中 。在活体外部研究中，不刺激皮肤，不诱导有机体突变的物质。具有广谱抗菌活性，其活性使用于广泛pH范围;其最小抑菌浓度为0.06%—1.00%。因其使用的安全性在化妆品中应用较大,一般用量为0.5-1%。该产品好象没有国家标((((((((((准,国际上通常以苯酚含量的指标简单判定。化妆品级产品含量((((((((((((((((((((((((((((要求99.5%,苯酚含量要求小于25ppm, 药用级产品含量要求(((((((((((((((((((((((((((((((99.9%,苯酚含量要求小于10ppm.。工业品90-99%,苯酚100ppm。((((((((((((((((((((((((((((((((((((((((国内有不良厂家使用工业品冒充化妆品级,这会大大增加产品对((((((((((((((((((((((((((((人体的危害性。 ((((((( loan management (post) review: 1, approval criteria have been implemented; 2, the contract is correct; 3, in line with the contract, payment; 4, no other major cases against loan security;、Reviewed by: date of record form 9: qilu bank borrowing by single years of maximum amount a maximum no-loan borrowers: borrowers: ... Borrower name number, line of credit expiry date year month day to year month day maximum number of years in the loan contract are the top line opened, the borrowed and requested your bank opened credit lines above, is hereby requested. Borrower signature: date agreed to open credit lines. Customer Manager signature: date agreed to open credit lines. Loan review signature: date line cancellation-I did not use the loan amount, your bank credit lines to be cancelled. -Credit loan principal repayment, your bank credit lines to be cancelled. Borrower signature: date-unused credit lines, agree to write off loans. -Credit loan principal repayment, agree to write off loans. Customer Manager signature: date case, agree to write off loans. Loan review signature: date of record form 16: qilu self credit for credit card cancellation application form name of borrower ID number and credit limit expiration date year month day to year month day year contract number self-service card-I do not use credit, your bank credit lines to be cancelled. -Credit loan principal repayment, your bank credit lines to be cancelled. Borrower signature: date-unused credit lines, agree to write off loans. -Credit loan principal repayment, agree to write off loans. Customer Manager signature: (三)苯氧乙醇的合成 1:在乙酸钠或氢氧化钠作用下，苯酚和环氧乙烷缩合，反应如下: 该法需要在温度200~C和0.2 0.25 MPa压力下进行,适宜大批量和工业生产 。 方法2采用威廉森(A(W(WiUiankson)合成法，选用苯酚钠和氯代乙醇，在常压下Il0?左右回流数小时，反应如下: 该法条件温和，适宜小批量生产和试验室制备。 (四)苯氧乙醇的有机合成实验 一 实验目的 利用威廉森法进行苯氧乙醇的有机合成。 loan management (post) review: 1, approval criteria have been implemented; 2, the contract is correct; 3, in line with the contract, payment; 4, no other major cases against loan security;、Reviewed by: date of record form 9: qilu bank borrowing by single years of maximum amount a maximum no-loan borrowers: borrowers: ... Borrower name number, line of credit expiry date year month day to year month day maximum number of years in the loan contract are the top line opened, the borrowed and requested your bank opened credit lines above, is hereby requested. Borrower signature: date agreed to open credit lines. Customer Manager signature: date agreed to open credit lines. Loan review signature: date line cancellation-I did not use the loan amount, your bank credit lines to be cancelled. -Credit loan principal repayment, your bank credit lines to be cancelled. Borrower signature: date-unused credit lines, agree to write off loans. -Credit loan principal repayment, agree to write off loans. Customer Manager signature: date case, agree to write off loans. Loan review signature: date of record form 16: qilu self credit for credit card cancellation application form name of borrower ID number and credit limit expiration date year month day to year month day year contract number self-service card-I do not use credit, your bank credit lines to be cancelled. -Credit loan principal repayment, your bank credit lines to be cancelled. Borrower signature: date-unused credit lines, agree to write off loans. -Credit loan principal repayment, agree to write off loans. Customer Manager signature: 二 实验原理 利用氢氧化钠溶液与苯酚合成苯酚纳，再利用合成的苯酚纳与95%氯乙醇在催化剂的作用下合成苯氧乙醇。化学方程式如下: CHO+NaOH CHONa+HO 66652 CHONa+ClCHCHOH PTC CHO+NaCl 61026522 三 实验器材 分馏柱 蒸馏头 冷凝管 电热套 玻璃棒 圆底烧瓶 温度计 尾接口 锥形瓶 烧杯 四 实验药品 NaOH溶液 化学纯苯酚 95,的氯乙醇 相转移催化剂 五 实验装置 loan management (post) review: 1, approval criteria have been implemented; 2, the contract is correct; 3, in line with the contract, payment; 4, no other major cases against loan security;、Reviewed by: date of record form 9: qilu bank borrowing by single years of maximum amount a maximum no-loan borrowers: borrowers: ... Borrower name number, line of credit expiry date year month day to year month day maximum number of years in the loan contract are the top line opened, the borrowed and requested your bank opened credit lines above, is hereby requested. Borrower signature: date agreed to open credit lines. Customer Manager signature: date agreed to open credit lines. Loan review signature: date line cancellation-I did not use the loan amount, your bank credit lines to be cancelled. -Credit loan principal repayment, your bank credit lines to be cancelled. Borrower signature: date-unused credit lines, agree to write off loans. -Credit loan principal repayment, agree to write off loans. Customer Manager signature: date case, agree to write off loans. Loan review signature: date of record form 16: qilu self credit for credit card cancellation application form name of borrower ID number and credit limit expiration date year month day to year month day year contract number self-service card-I do not use credit, your bank credit lines to be cancelled. -Credit loan principal repayment, your bank credit lines to be cancelled. Borrower signature: date-unused credit lines, agree to write off loans. -Credit loan principal repayment, agree to write off loans. Customer Manager signature: 六 实验步骤 1 加人15g化学纯苯酚，搅拌下加人适量氢氧化钠溶液，约10min后成透明状。 2 加人13.5g95,的氯乙醇和是它重量l5,的相转移催化剂，即刻出现白色沉淀。 3 在50?下搅拌lh，进行分离提纯。 4 称量，计算产率。 参考文献 周湘云 《苯氧乙醇的性质,制备和应用》 1991年第5期《化工周刊》P24-P26 王箴 《化工辞典》 北京:化学工业出版社第三版，P417 裘炳毅《化妆品化学与工艺技术大全》 北京:中国轻工业出版社，1997(P417 loan management (post) review: 1, approval criteria have been implemented; 2, the contract is correct; 3, in line with the contract, payment; 4, no other major cases against loan security;、Reviewed by: date of record form 9: qilu bank borrowing by single years of maximum amount a maximum no-loan borrowers: borrowers: ... Borrower name number, line of credit expiry date year month day to year month day maximum number of years in the loan contract are the top line opened, the borrowed and requested your bank opened credit lines above, is hereby requested. Borrower signature: date agreed to open credit lines. Customer Manager signature: date agreed to open credit lines. Loan review signature: date line cancellation-I did not use the loan amount, your bank credit lines to be cancelled. -Credit loan principal repayment, your bank credit lines to be cancelled. Borrower signature: date-unused credit lines, agree to write off loans. -Credit loan principal repayment, agree to write off loans. Customer Manager signature: date case, agree to write off loans. Loan review signature: date of record form 16: qilu self credit for credit card cancellation application form name of borrower ID number and credit limit expiration date year month day to year month day year contract number self-service card-I do not use credit, your bank credit lines to be cancelled. -Credit loan principal repayment, your bank credit lines to be cancelled. Borrower signature: date-unused credit lines, agree to write off loans. -Credit loan principal repayment, agree to write off loans. Customer Manager signature: