福尔马林（formalin）

福尔马林（formalin） 福尔马林(formalin) formalin 1. Formalin: formalin is the aqueous solution of "formaldehyde" (formaldehyde) (HCHO). The appearance is colorless, transparent, corrosive, and because of the strong volatility of the formaldehyde contained in it, Once the bottle is opened, it suddenly gives off a strong pungent odor. An aqueous solution of 35% to 40% formaldehyde (usually 37%) is also added to 10%~15% methanol to prevent polymerization. It has antiseptic, antiseptic and bleaching functions. Different fields have different functions. Two: toxicity may cause harm to humans: According to many medical reports, human skin can cause allergic reactions, dermatitis or eczema if it is in direct contact with formalin, In particular, people who need long-term contact with Faure Marin at work will often have this phenomenon. Therefore, it is necessary to avoid direct contact with the skin, and touch it carelessly. Rinse with water immediately. Formaldehyde volatile, strong irritant to the eyes, with damage, if inadvertently formalin liquid contact eye, please quickly rinse with plenty of water for at least 15 minutes or more, and medical treatment as soon as possible. When inhaled accidentally, Will stimulate the mouth, nose and respiratory mucosa tissue, light pain, cough, heavy respiratory tract inflammation, and even pulmonary edema, please check for medical treatment should be appropriate. If you accidentally drink too much, there is a fatal possibility. Formaldehyde and its oxidation products, formic acid, which exceed the safety value, can cause harm to the human body. The first aid measures should be consulted before the use of Faure Marin, so as to ensure the safety of the body. Many scientific studies and animal experiments have long pointed out that long-term exposure to formalin may lead to cancer, which has been listed as a "suspected carcinogen.""! The trace amounts of formaldehyde in the human body basically residue is not strong, slow metabolism, approximately 35% metabolism of formic acid, and formic acid in urine from the salt type, the remaining 65% can continue metabolism for the carbon dioxide and water removal, But the biggest problem is that it can cause cell degeneration! Moreover, bacteria, isolated cells or animal cells tested positive for gene mutation and could not rule out possible biological abnormalities! Three: methods for drug analysis: Determination of Formaldehyde Solution formaldehyde neutralization titration Application: this method uses titration method to determine the content of formaldehyde in Formaldehyde Solution. The method is applicable to Formaldehyde Solution. Methods: the sample was the principle of conical flask, add water, hydrogen peroxide solution and bromine thymol blue indicator solution, NaOH titrant solution to blue, And then add sodium hydroxide titration liquid, the mouth of a small glass funnel, placed in the water bath heating, shaking from time to time, and cold, wash funnel with water, add bromine, thymol blue, indicating liquid 2 drops, Titrate the solution to the solution by titration with hydrochloric acid. The result of titration is corrected by blank test. The amount of formaldehyde is calculated according to the amount of titrant used. Reagent: 1. bromo thymol blue indicator solution (BTB solution) 2) hydrogen peroxide solution. 3) hydrochloric acid titration solution (1mol/L) 4) sodium hydroxide titration solution (1mol/L) 5) phenolphthalein liquid. 6) methyl methyl green methyl green mixed indicator 7) reference potassium phthalate two formic acid 8) standard anhydrous sodium carbonate Specimen preparation: 1. bromo thymol blue indicator solution (BTB solution) Take thymol blue 0.1g, add 0.05mol/L sodium hydroxide solution, 3.2mL, dissolve, and then dilute it to 200mL with water. 2. hydrogen peroxide solution Take the concentrated hydrogen peroxide solution (30%) and dilute it with water to 3% of the solution. 3. hydrochloric acid titration solution (1mol/L) Preparation: take hydrochloric acid 90mL, add water to make 1000mL, shake well. Calibration: take the temperature of 270~300 DEG C to the base of constant weight. The anhydrous sodium carbonate is about 1.5g, and the precision is fixed. Add water 50mL to dissolve, add methyl red bromine green green mixed indicator liquid 10 drops, Titrate with this solution until the solution is changed from green to violet. Boil for 2 minutes, cool to room temperature, continue to titrate until the solution turns green to dark purple. Each 1mL hydrochloric acid titration solution (1mol/L) is equivalent to 53.00mg anhydrous sodium carbonate. According to the consumption of the liquid and the amount of anhydrous sodium carbonate, the concentration of the liquid is calculated. 4. sodium hydroxide titration solution (1mol/L) Preparation: take proper amount of sodium hydroxide and shake with water to dissolve into saturated solution. After cooling, place it in polyethylene plastic bottle and leave it for several days. Clear and reserve. Take the clarified sodium hydroxide saturated solution 56mL, add a new boiling cold water to make 1000mL, shake it well. Calibration: take at 105 degrees dry to constant weight benchmark, phthalate two formic acid potassium hydrogen is about 6G, precise call, add new boiling cold water 50mL, vibration shake, make it dissolve as much as possible, Add 2 drops of phenolphthalein solution, with the droplets, close to the end point, the two phthalic acid potassium hydrogen dissolved completely, Significant pink by titration to solution. Each 1mL of sodium hydroxide titration solution (1mol/L) is equivalent to 204.2mg of potassium hydrogen phthalate two. According to the consumption of this liquid and the dosage of potassium hydrogen phthalate two, the concentration of this liquid is calculated. Storage: in polythene plastic bottle, sealed and sealed; there are 2 holes in the plug, 1 glass tubes are inserted into each hole, and the 1 tube is connected with the Soda Lime tube, and the 1 tube is used for sucking out the liquid. 5. phenolphthalein solution Take 1g 100mL to add phenolphthalein, ethanol solution. 6. methyl red bromine green mixed indicator Take 0.1% methyl alcohol solution 20mL, and add 0.2% bromo green ethanol solution 30mL, shake well. Steps: take the sample of about 1.5mL, precision said, a conical flask, add 10mL of water, hydrogen peroxide solution 25mL and bromothymol blue indicator 2 drops of liquid, adding sodium hydroxide titration solution (1mol/L) solution to blue, Precision and sodium hydroxide titration solution (1mol/L) 25mL, a small bottle of glass funnel, heating on the water bath for 15 minutes, shaking from time to time, put cold water washing funnel with bromothymol blue indicator 2 drops of liquid, titrated with hydrochloric acid solution (1mol/L) titration solution to yellow, The result of titration is corrected by blank test. Each 1mL of sodium hydroxide titration solution (0.1mol/L) is equivalent to 30.03mg CH2O. Note: "precision weighing" means that the weight shall be accurate to 1/1000 of the said weight. The precision measurement refers to the accuracy of the volume measurement, and should meet the requirements of the national standards for the accuracy of the volume pipette. Four: pharmaceutical characteristics, Faure Marin is a broad-spectrum seed disinfectant. Industrial products are colorless or light yellow liquid, with a strong pungent odor. Faure Marin, a medicinal substance, is a colorless transparent liquid that has a strong stimulating effect on the skin and eyes. Five: use: Faure Marin covers a wide range of uses, in which formaldehyde can be combined with the amino group of protein, so that the protein coagulation, so in medicine can be used as a test of tissue fixative, As well as preservatives. When the concentration and dosage are adequate, this property is destructive to most microorganisms and is often used as a disinfectant. And Faure Marin in industrial use, nature is also quite a lot, For example, it is used in the manufacture of adhesives, dyes, coatings and so on. The products derived from them are quite easy to come into contact with "the possible source of asthma" in our life. The animal husbandry is often collocation "Potassium Permanganate" with formalin "Potassium permanganate" for disinfection of formaldehyde or smoke before hatching. As for the treatment of fish diseases, at least eighty years of history, for in vitro parasites and fungi, bacteria and virus infection, There are good forces. Its main advantages are its inexpensive and rapid and effective treatment of pathogens and so on. And formalin is also of great use in medicine. Before the autopsy, in order to preserve it well, it should be soaked in formalin. At present, the market is common to Faure Marin, formaldehyde concentration of about 24% to 40% between, in medicine, the definition of Faure Marin refers to more than 35% or more than 37% formaldehyde water solution. Faure Marin is an aqueous solution of formaldehyde is protein coagulant. The effect of temperature, environment and use of water temperature at 23 to 26 DEG C for 48 hours, the maximum safe concentration is 56PPm, the actual use of 30PPm is a usually harmless, When the water temperature is above 28 DEG C, the efficacy of the medicine can kill the plankton in water. The formaldehyde is a colorless liquid and has antiseptic function, such as the antiseptic function of the corpse. For fish farming, diluting water in proportion can activate tired fish and make them more active, But not suitable for entrance and face contact. The day before the elderly accidental poisoning case. In order to prevent excessive Faure Marin harm to the human body, the State Administration of quality supervision and inspection and Quarantine issued the domestic sales of fiber products (including fabrics and accessories) Faure Marin content standards, and from January 1, 2003 formally implemented. Food cannot be kept. Faure Marin in fiber products is mainly used for dyeing auxiliaries and finishing agent to improve resin wrinkle, shrinkproof effect. Medical experts believe it is a chronic poisoning drug, Long term exposure to low doses of formalin can cause chronic respiratory diseases, menstrual disorders in women, lower neonatal constitution, and even nasopharyngeal cancer. High concentrations of Faure Marin are toxic to the nervous system, the immune system, and the liver. In addition to being illegal home do aquatic products processing Some food preservative processing. Six: traits: A colorless liquid with a pungent odor. Formaldehyde is a highly irritating toxic gas, Flammable and corrosive, can be detected in the general air trace, easily soluble in water, usually made by chemical oxidation of methanol. Formaldehyde can be obtained after oxidation of methanol, and formic acid can be obtained after formaldehyde continues to oxidize. The three are toxic substances, in the same dose, in terms of toxicity to humans, the toxicity ratio is methanol: formaldehyde: formic acid = 1:30:6, The toxicity of formic acid is six times of that of methanol, and the toxicity of formaldehyde is thirty times of that of methanol. And Faure Marin can not contact strong oxidants, strong alkali, phenols, urea and other substances, easy to cause chemical reactions, causing danger. The pharmacological effect of 35 - 40% formaldehyde aqueous solution is called formalin Prevent the synthesis of nuclear proteins, inhibit cell division and inhibit the synthesis of nucleus and cytoplasm, leading to microbial death. Use: effectively kill bacteria, propagule, or kill spores (e.g. anthrax spores). And strong resistance to TB, viruses. For animal barn, warehouse, egg chamber, fur, clothing, appliances such as fumigation and specimen, embalming; also used in gastrointestinal system yeast. Seven: Faure Marin, formalin, fortune Merrill, Faure Marin Formaldehyde English Name: Formaldehyde, methanal Chinese Pinyin: Jia Quan Main ingredients: formaldehyde Structural formula: H-C=0 Molecular formula: CH2O Molecular weight: 30.03