2014_ IDEX OEMCatalog_lr

2014 CATALOG FLUIDIC PRODUCTS & INFORMATION for INSTRUMENT MANUFACTURERS YOU MAKE GREAT INSTRUMENTS TRUST IDEX HEALTH & SCIENCE PRODUCTS TO MAKE THEM EVEN BETTER Since 2006, IDEX Health & Science has been the expert in fluidic pathway products and applications, helping OEMs make better instruments for critical chemical analysis, separations, and in vitro diagnostic testing. Thanks to our problem solving, engineering, and precision manufacturing expertise, we are leaders in the industry. Our fluidic portfolio is unsurpassed, and with our people, know-how, and products, we can help you make your instruments the best-in-class so you can win. Looking forward, we will continue to take on the most difficult and rewarding challenges in fluidics. This includes micro/nano chip-based systems, and high-throughput chemically stringent processes — with innovative new products and thinking — to maintain our leadership position in Life Science applications. Internally, IDEX Health & Science will continue to invest in operational and commercial teams to meet the growing demands of the markets and ultimately you, our customer. We thank you for doing business with IDEX Health & Science, and we look forward to an even greater partnership bringing the world the best-engineered scientific fluidics for today and tomorrow. John Arnott President, IDEX Health & Science LLC ISO 9001-2000 • ISO 13485 • RoHS • REACH John Arnott, President, IDEX Health & Science LLC The products on these pages are for instrument manufacturers. Volume purchase or contract requirements apply. 2 INTRODUCTION 1 IN THIS CATALOG 1 TABLE OF CONTENTS 2 Who We Are 2 Why We’re Different 3 What We Do For You 6 Critical Instrument Fluidics for Life Sciences 8 PRECISION DISPENSE PUMPS 9 Introduction to Precision Dispense Pumps 10 V-Series Pumps 11 IPV 11 PVM Drive/IPV 11 S-Series Pumps 12 Ultra High Pressure Check Valves & Pump Components 13 Specialized Peristaltic Pumps 14 ROTARY SHEAR VALVES 15 Introduction to Rotary Shear Valves 16 TitanHT™ 17 TitanHP™ 18 TitanEZ™ 19 Implementation Examples 20 FLUIDIC MANIFOLDS 21 Introduction to Fluidic Manifolds 22 Case Studies 22 Integrated Assemblies and Custom Features 23 Common Materials 24 CUSTOM CONNECTIONS 24 High Pressure Fittings 24 Low Pressure Fittings 25 Stainless Steel Formed Tubing 25 High Pressure Tubing Assemblies 25 Polymer Formed Tubing 25 Low Pressure Tubing Assemblies 26 COLUMN HARDWARE 27 Biocompatible Column Hardware for UHPLC 28 IsoBar Column Systems 29 Modular Column Systems 29 Modular Column Packing Adapters 30 DEGASSING 30 Debubblers and Degassers 30 High-Flow Degassers 32 OEM Mini Degasser 33 Debubbler Series 34 Online Degassers 35 RefractoMax 1 TABLE OF CONTENTS WHO WE ARE IDEX Health & Science manufactures highly respected fluidic components used in instruments that require precise, low-volume control for sample processing, reagent management, sample chemistries, and other analytical tasks performed with fluids. WHY WE’RE DIFFERENT IDEX Health & Science is the flow path expert We present the broadest portfolio of fluidic technologies available, plus the specialty engineering resources to resolve newly recognized issues that arise as scientific innovation progresses beyond the known levels of complexity, miniaturization, and sample throughput. f How does liquid behave in a tube with a flow path smaller than a human hair? fWhat makes fluidic precision even more challenging at atmospheric pressure than at 30,000 psi? Or at nano flow rates? fWhat does it take to build a pump that delivers unparalleled accuracy and precision for the life of a diagnostic instrument? And, after you’ve made that first pump, how do you scale production rapidly to meet the demand for 300 or 5,000 pumps the first year alone? Backed by the resources of IDEX, a provider of engineered products, in business for more than twenty-five years, IDEX Health & Science does. Rotary shear valves XX Pressures from 0 to 25,000 psi XX Switching, Injection, Selection flow paths XX Custom valve development Specialized peristaltic pumps XX New independent-channel control XX 1- to 24-channel designs XX Digital and analog control Tubing, connections XX Low-to-high pressure tubing, connections XX Time-saving tubing assemblies XX Newest PEEK-lined stainless steel (PLS) 2 IDEX HEALTH & SCIENCE Precision dispense pumps XX Dispensing: 1 to 5,000 µL at 1% CV XX Long life — 2 to 5 million cycles XX Eliminate preventive maintenance XX Custom LC-pump components Column hardware XX NEW Interactive Column Selector XX NEW biocompatible materials XX Accessories for column protection Innovative fluidic manifolds XX Custom designed to the instrument XX Advanced engineering materials XX Hematology, immunoassay, flow cytometry, clinical chemistry, sequencing XX In vitro diagnostics, genomics, biotechnology Degassing and detection technologies XX Active degassing and debubbling XX Increased instrument precision XX Chromatography and IVD applications WHAT WE DO FOR YOU IDEX Health & Science offers standard and custom products known for best-in-class fluidic performance in critical chemical analysis, separations, and diagnostic applications. We leverage our deep application knowledge to improve the portfolio through innovation to stay ahead of market trends, like higher pressure, biocompatible materials, dispense precision, power consumption, and component size. In many cases, our integrated IDEX Health & Science assemblies, which provide turnkey installation, can reduce customer assembly and test cost significantly, offering the greatest possible value for you. 3IDEX HEALTH & SCIENCE Download the Idea Book today at www.idex-hs.com/ ideabook ONLY CUSTOM? MAYBE NOT. Our companion lab catalog offers approximately 3,000 parts most requested by laboratories. Still, that’s only a fraction of the products available to OEMs. We routinely make thousands of specialized parts for volume customers. Suppose a part you need isn’t listed. That doesn’t always mean we’d start with a blank CAD screen to make it for you — nor that it always requires lengthy development time. In fact, we may already be far along the timeline of delivery to you — so please ask! Behind the scenes, a vast library of product configurations, functions, and proven materials already exists for every product line, as well as a deep talent pool of experienced manufacturing specialists who machine, mold, extrude, and assemble our products. Even so, we still can’t say YES! to every request for custom development. ADVANCED FLUIDIC DESIGN Authored by the Director of Strategic R&D for IDEX Health & Science, Dr. Darren Lewis, The IDEA Book is a design engineer’s guide to fluidic design and integration. Highly readable, yet deeply technical, The IDEA Book condenses years of fluidic development practice into 60 pages of inspiration. 4 IDEX HEALTH & SCIENCE Demand for these high-precision fluidic products is high, as is the need for constant technical innovation. To stay ahead of our rapidly evolving markets, the scientists, engineers, and technical experts who design and make IDEX products must focus on meeting the needs of these emerging technologies such as micro- and nano-fluidics, chip-based analyses, and point-of-care. Over the years, we’ve learned that certain custom requests align well with the development goals of our IDEX brands. We’re most likely to accept these custom projects when your goals match ours. Other qualifications include number of systems required, timing to market, anticipated lifetime of the instrument platform, and whether we’d work on only part of your flow path or the entire fluidic circuit. We win when we win together. Scientific instruments that utilize our highly precise, low-volume fluidic expertise all encompass several common fluidic tasks. We excel at four, and can contribute greatly to your instrument in these areas: Sampling; Reagent Handling; Sample Chemistry; Wash Systems. Of course, when we execute your entire fluidic circuit, we handle everything for you — and that’s where you realize the greatest economy and instrument efficiency. However, if you ask us for custom engineering outside our areas of greatest interest, (e.g. bulk fluid management or waste fluid removal) we’ll probably refer you to someone who can better meet your budget requirements. On the next two pages, we’ll illustrate simple approaches to the four areas we consider critical to any instrument. 5IDEX HEALTH & SCIENCE D C B AA B C D 12345678 8 7 6 5 4 3 2 1 THE INFORMATION CONTAINED IN THIS DRAWING IS THE SOLE PROPERTY OF . ANY REPRODUCTION IN PART OR AS A WHOLE WITHOUT THE WRITTEN PERMISSION OF IS PROHIBITED. PROPRIETARY AND CONFIDENTIAL NEXT ASSY USED ON APPLICATION DIMENSIONS ARE IN INCHES TOLERANCES: FRACTIONAL ANGULAR: MACH BEND TWO PLACE DECIMAL THREE PLACE DECIMAL INTERPRET GEOMETRIC TOLERANCING PER: MATERIAL FINISH DRAWN CHECKED ENG APPR. MFG APPR. Q.A. COMMENTS: DATENAME TITLE: SIZE B DWG. NO. REV WEIGHT: SCALE: 1:2 UNLESS OTHERWISE SPECIFIED: PUMP ASSY 5000uL, 1.125 STK, W/ W, W/E SHEET 1 OF 1 87-7221WE-5000-207-0006 DO NOT SCALE DRAWING D C B AA B C D 12345678 8 7 6 5 4 3 2 1 THE INFORMATION CONTAINED IN THIS DRAWING IS THE SOLE PROPERTY OF . ANY REPRODUCTION IN PART OR AS A WHOLE WITHOUT THE WRITTEN PERMISSION OF IS PROHIBITED. PROPRIETARY AND CONFIDENTIAL NEXT ASSY USED ON APPLICATION DIMENSIONS ARE IN INCHES TOLERANCES: FRACTIONAL ANGULAR: MACH BEND TWO PLACE DECIMAL THREE PLACE DECIMAL INTERPRET GEOMETRIC TOLERANCING PER: MATERIAL FINISH DRAWN CHECKED ENG APPR. MFG APPR. Q.A. COMMENTS: DATENAME TITLE: SIZE B DWG. NO. REV WEIGHT: SCALE: 1:2 UNLESS OTHERWISE SPECIFIED: PUMP ASSY 5000uL, 1.125 STK, W/ W, W/E SHEET 1 OF 1 87-7221WE-5000-207-0006 DO NOT SCALE DRAWING CRITICAL INSTRUMENT FLUIDICS FOR LIFE SCIENCES Reagent To waste Pu m p Valve Mixingtee A pump Reagent To waste Valve B pump P um p To manifold Sampling Sample Analysis always involves limited quantities that must be preserved in a discrete fluid plug without carryover to another sample. Largely from biological sources, analytes are not purified and may contain artifacts unwanted in the analysis, yet typically small volumes preclude use of most filters. In this automated sample example, a positive displacement pump aspirates sample through a probe info a fixed loop. A rotary valve then switches the sample to an outlet stream for dispensing to devices downstream. The unique valve configuration allows complete rising of the pump between samples to prevent carryover. Flow cell Sample vial Probe Wash Station Sample Well Flow cell Sample vial Probe Wash Station Sample Well Mode 1: Reagent from probe Mode 2: Inject sample Sampling Fluidic design ideas suggested on these pages are neither examples of, nor recommendations for any specific application. Reagent Handling Reagent delivery systems channel purified, homogeneous solutions that — while abundant in volume — must be preserved and managed to maintain a flow path free of crystals, sediments, or particulates. Ideal reagent management involves unidirectional flow, back-flow prevention, and routine rinsing protocols to ensure optimal preservation of expensive reagents. This example illustrates extremely regulated reagent mixing prior to introduction to a manifold. Alternately — or subsequently — internal mixing could occur within the manifold’s mixing channels. Reagent Handling 6 IDEX HEALTH & SCIENCE D C B AA B C D 12345678 8 7 6 5 4 3 2 1 THE INFORMATION CONTAINED IN THIS DRAWING IS THE SOLE PROPERTY OF . ANY REPRODUCTION IN PART OR AS A WHOLE WITHOUT THE WRITTEN PERMISSION OF IS PROHIBITED. PROPRIETARY AND CONFIDENTIAL NEXT ASSY USED ON APPLICATION DIMENSIONS ARE IN INCHES TOLERANCES: FRACTIONAL ANGULAR: MACH BEND TWO PLACE DECIMAL THREE PLACE DECIMAL INTERPRET GEOMETRIC TOLERANCING PER: MATERIAL FINISH DRAWN CHECKED ENG APPR. MFG APPR. Q.A. COMMENTS: DATENAME TITLE: SIZE B DWG. NO. REV WEIGHT: SCALE: 1:2 UNLESS OTHERWISE SPECIFIED: PUMP ASSY 5000uL, 1.125 STK, W/ W, W/E SHEET 1 OF 1 87-7221WE-5000-207-0006 DO NOT SCALE DRAWING D C B AA B C D 12345678 8 7 6 5 4 3 2 1 THE INFORMATION CONTAINED IN THIS DRAWING IS THE SOLE PROPERTY OF . ANY REPRODUCTION IN PART OR AS A WHOLE WITHOUT THE WRITTEN PERMISSION OF IS PROHIBITED. PROPRIETARY AND CONFIDENTIAL NEXT ASSY USED ON APPLICATION DIMENSIONS ARE IN INCHES TOLERANCES: FRACTIONAL ANGULAR: MACH BEND TWO PLACE DECIMAL THREE PLACE DECIMAL INTERPRET GEOMETRIC TOLERANCING PER: MATERIAL FINISH DRAWN CHECKED ENG APPR. MFG APPR. Q.A. COMMENTS: DATENAME TITLE: SIZE B DWG. NO. REV WEIGHT: SCALE: 1:2 UNLESS OTHERWISE SPECIFIED: PUMP ASSY 5000uL, 1.125 STK, W/ W, W/E SHEET 1 OF 1 87-7221WE-5000-207-0006 DO NOT SCALE DRAWING Sample Chemistry Sample chemistry involves creating an environment favorable for desired reactions between samples and reagents. A manifold, with mixing chambers, heating or conductive elements, provides a well-swept flow path that enables consistent mixing and reproducible reactions. A compact manifold utilizes small reagent volumes, reducing the cost per test. This configuration shows a methodology for sequentially acquiring samples, then using a second drive pump to mix the samples with a reagent, followed by incubation with a reaction cell. Wash Systems Material/chemical compatibility often tops flow- rate precision in wash/rinse systems where harsh reagents such as bleach or alcohol may be used. Our wash systems include completely reproducible methods that remain consistent over time. This example shows sequential injection of timed sample plugs using alternating injection loops on a shear valve. A thorough rinse protocol ensures low sample carryover between injections. Economical waste pumps drain spent fluids post-analysis. Fluidic System Integration Although each fluidic system is unique, some fundamental principles guide our development. We design compact, consistent fluidic circuits that lower cost per test and support high-quality analysis. We start with what you want to accomplish. Analytical considerations like flow cell positioning drive the design; fluid ratios, flow rates, and dispense volumes support the science. We position components to speed assembly and enable preventive maintenance. There’s lots more. Call us! Fluidic design ideas suggested on these pages are neither examples of, nor recommendations for any specific application. Probe Waste Loop 1 Loop2 Load pump Mixing manifold Reagent 1 Reagent 2 Reactant Pump Sample Chemistry Loop2 Wash Loop 1 To waste Flow cell Probe Peristaltic drive pump Peristaltic waste pump Probe Wash Systems 7IDEX HEALTH & SCIENCE PRECISION DISPENSE PUMPS IDEX Health & Science offers an array of high-precision, long-life pumps for low volume applications. Pumps from the three product lines are commonly deployed in HPLC, clinical chemistry, hematology, and other IVD instruments. For lower-pressure applications, below 1,500 psi (< 100 bar), the V-Series offers a platform that provides precise dispensing and life-of-instrument performance. The VFP17 pump allows for custom mounted valving and includes various materials to ensure chemical compatibility. Whether used as a single pump, or combined with multiple units in a fluidic manifold, the V-Series is designed to be flexible and maintenance-free. S-Series pumps provide steady flow rates and handle higher-pressure applications up to 5,000 psi (345 bar). The IPV (Integrated Piston and Valve) offers users of syringe pumps a long-life alternative to expensive glass syringes. 8 FOR OEMs 9PRECISION DISPENSE PUMPS Dispense Pumps V17 VP17 VFP17 IPV S17 Standard Sizes (total pump volume) 50 µL, 100 µL, 500 µL, 1 mL 50 µL, 100 µL, 500 µL, 1mL 25 µL, 50 µL, 100 µL, 250 µL, 500 µL, 1 mL, 2.5 mL, 5 mL 100 µL, 250 µL, 500 µL, 1 mL, 2.5 mL, 5 mL 50 µL, 100 µL, 250 µL, 500 µL, 1 mL, 2 mL, 3 mL, 5 mL Maximum Operating Pressure 500 psi (30 bar) 500 psi (30 bar) 1500 (100 bar) 100 psi (7 bar) 5,000 (345 bar) Dispense Volume Min/Full Step 0.0125 µL (50 µL) to 0.5000 µL (1 mL) 0.0125 µL (50 µL) to 0.5000 µL (1 mL) 0.0063 µL (25 µL) to 2.500 µL (5 mL) * 0.0083 µL (50 µL) to 0.5556 µL (5 mL) Dispense Rate Maximum (mL/min) 3.7 (50 µL) to 75 (1 mL) 3.7 (50 µL) to 75 (1 mL) 1.8 (25 µL) to 250 (5 mL) * 1.2 (50 µL) to 125 (5 mL) Dispense Inaccuracy ± 0.4% at full dispense ± 0.4% at full dispense ± 0.4% at full dispense * < 1% Dispense Precision 2% dispense: < 1.0% CV 2% dispense: < 1.0% CV 2% dispense: < 1.0% CV * 100% dispense: < 0.2% CV 10% dispense: < 0.5% CV 1% dispense: < 2% CV Resolution (full steps per stroke) 2,000–4,000 2,000–4,000 2,000–4,000 * 3,000–6,000 Wetted Materials: Head Acrylic Acrylic Acrylic Standard; PEEK, Ultem®, Udel®, others available PEEK Standard; Ultem and Udel available Utlem Standard; custom materials available Wetted Materials: Piston TZP Ceramic; Sapphire TZP Ceramic; Sapphire TZP Ceramic; Sapphire TZP Ceramic TZP Ceramic; Sapphire Wetted Materials: Seal UHMWPE, Viton®, Customizable UHMWPE, Viton, Customizable UHMWPE, Viton, Customizable UHMWPE, Viton UHMWPE, Viton, Customizable Operating Temperature 60–100 °F / 15–45 °C 60–100 °F / 15–45 °C 60–100 °F / 15–45 °C 62–104 °F / 17–40 °C 60–100 °F / 15–45 °C Anticipated Life 2 million cycles 5 million cycles 5 million cycles 3 million cycles 5 million cycles 1.8 degree Bipolar Stepper Motor Yes Yes Yes * Yes Voltage 24 V 24 V 24 V * 24 V Encoder Option Option Option * Option Controller Board Not included Not included Not included Available with optional PVM Not included Seal Wash Option Option Option Limited Option Option Connection Ports 1/4-28 or M6 1/4-28 or M6 1/4-28 or M6 1/4-28 or M6 1/4-28 or M6 Home Position Aspirate or Dispense Aspirate or Dispense Aspirate or Dispense * Aspirate or Dispense * IPV fluidic dispense profiles and specifications are dependent upon the companion drive controller deployed. Standard V-Series Pump Specifications Total Pump Volume (µL) Lead Screw Pitch (TPI) Resolution (µL/full step) Min. Dispense for 1% CV (µL) Time to Fully Dispense (sec) Max. Backlash to Total Volume (%) Unswept Volume (µL) Seal Wash Volume (µL) V17, VP17 VFP17 V17, VP17 VFP17 V17, VP17 VFP17 25 20 0.0125 0.5 N/A 0.8 1 N/A 12 N/A 25 40 0.0063 0.5 N/A 1.5 50 20 0.0250 1 0.7 0.8 1 97 19 45 32 40 0.0125 1 1.3 1.5 100 20 0.0501 2 0.7 0.8 1 131 27 55 42 40 0.0251 2 1.3 1.5 250 20 0.1250 5 N/A 0.8 1 N/A 40 N/A 41 40 0.0625 5 N/A 1.5 500 20 0.2499 10 0.7 0.8 1 316 61 105 89 40 0.1250 10 1.3 1.5 1000 20 0.5000 20 0.7 0.8 1 507 96 159 145 40 0.2500 20 1.3 1.5 2500 20 1.2496 50 N/A 1.0 1 N/A 194 N/A 247 40 0.6248 50 N/A 1.8 5000 20 2.4996 100 N/A 1.2 1 N/A 344 N/A 376 40 1.2498 100 N/A 2.4 * Dispense may vary with back pressure, step mode, drive current, or other application parameters. V17 2 million cycles; Precision dispensing applications with lower duty cycle VP17 5 million cycles; Economical balance of precision & high duty cycle performance VFP17 5 million cycles; Long life, precision fluidics & custom options (including mounted valves) V-SERIES PUMPS The V-Series is a f