氟尼辛葡甲胺(完)

氟尼辛葡甲胺(完) 氟尼辛葡甲胺 一、 产品说明、使用说明及产品的包装规格。 ?产品说明: 氟尼辛葡甲胺(flunixin meglumine)是一种新型的、非甾体类动物专用的解热镇痛药物，属于烟酸类衍生物，是环氧化酶的抑制剂。一种有效的非麻醉、非类固醇类的解热镇痛消炎、抗内毒素药物，是目前唯一的动物专用解热镇痛消炎药。由美国先灵葆雅公司于20世纪90年代开发，由于其解热镇痛抗炎效果好且毒性低、现已在美国、法国、瑞士、德国、英国等许多国家广泛用于数种动物的多种疾病的治疗，如马疝痛、内毒血症和骨骼肌肉紊乱;反刍动物乳房炎、肺炎、内毒血症;猪子宫内膜炎、乳房炎和和无乳综合症;犬内毒素血症、腐败性腹膜炎、骨关节炎和骨骼肌肉紊乱。在我国主要用于马、牛、猪、猫、犬、羊等动物感染性疾病引起的发热及急性炎症，还可用于缓解马肌肉骨骼系统病症和腹痛伴有的炎症反应和疼痛，用于母猪的子宫内膜炎、乳房炎和和无乳综合征的;犬内毒素血症等。 氟尼辛葡甲胺是氟胺烟酸与葡甲胺的复合盐，易溶于水，水溶液呈碱性，化学性质稳定。作为唯一动物专用的非甾体类解热镇痛抗炎药，氟尼辛葡甲胺已被USP和EP收录。非甾体类解热镇痛药，由于其起效迅速，可解热、可减轻炎症肿胀及抑制疼痛，而对疾病的进程乃至愈后发挥着至关重要的作用，临床需求量十分巨大。氟尼辛葡甲胺与传统的非甾体类解热镇痛抗炎药相比，其化学结构独特，解热镇痛抗炎作用强，毒副作用低，按常规剂量合理使用不会产生任何不良反应，，是唯一被批准用于泌乳期奶牛的非甾体类解热镇痛抗炎药。 齐鲁动物保健品有限公司依据自身科研力量开发出符合USP和EP的高品质氟尼辛葡甲胺原料，在国内具有领先水平，已于2007年6月1日被农业部批准为国家三类新兽药，证书编号为(2007)新兽药证字23、24号。 【 化学名称】:2-,2-甲基-3-(三氟甲基)苯胺基,氨基,-3-吡啶羧酸复合1-脱氧-1-(甲氨基)-D-山梨醇 (1?1); 【 结构式】: application; infection and antibacterial drug of clinical application; transfusion refers to levy; nutrition support of adapted card and clinical application; common life support technology (as cycle breathing support, and nutrition support,) and emergency technology of application; common guardianship instrument using. Look: shock, cardiac respiratory arrest and acute organ failure, systemic inflammatory response syndrome and severe infection and multiple organ dysfunction syndrome (MODS), severe disturbance of body fluid environment such as critical theory and progress of the illness. 2. basic requirements (1) species and cases of study requirements: severe pneumonia in disease-disease myocardial infarction ... 3. high requirements (1) learning disease species: disease species disease species image radiation: rheumatic heart congenital heart intestinal Crohn's (Crohn) disease intestinal tuberculosis bile duct cancer chronic pancreatic inflammatory urinary system stone urinary system tumor adrenal disease thyroid disease cranial within infection nervous system tumor nuclear medical: Digest road bleeding explicit like brain blood flow perfusion explicit like testicular blood pool explicit like salivary glands explicit like (2) clinical knowledge, and skills requirements: understand various image check 【 分子式】:CHFNO?CHNO14113227175 【 分子量】:491.46 使用说明: 【适应症】 马 可治疗马的内毒血症，缓解马疝痛、肌肉反常引起的炎症和痛觉及马的内脏绞痛，同时可治疗马驹的腹泻、颤抖、结肠炎、 呼吸系统疾病、眼部手术等。 牛、羊 治疗呼吸系统疾病，大肠杆菌产生的内毒素引起的乳腺炎，内毒 血症。 猪 治疗子宫内膜炎、乳房炎、无乳综合症及腹泻等。 犬、猫 治疗内毒血症、腐败性腹膜炎、骨关节炎、骨骼肌肉紊乱、发热、腹泻、颤抖、眼部感染等。 【用法与用量】 马 肌内或静脉注射，用量按体重1.1 mg/kg(氟尼辛计)，每日1-2次，连续治疗3-5天。 牛、羊 肌内或静脉注射，用量按体重2.2 mg/kg(氟尼辛计)，每日1-2次，连续治疗3-5天。 猪 肌内或静脉注射，用量按体重1.1,2.2 mg/kg(氟尼辛计)，每日1-2次，连续治疗3-5天。 犬、猫 肌内或静脉注射，用量按体重1.1,2.2 mg/kg(氟尼辛计)，每日1-2次，连续治疗3-5天。 【药动学】 application; infection and antibacterial drug of clinical application; transfusion refers to levy; nutrition support of adapted card and clinical application; common life support technology (as cycle breathing support, and nutrition support,) and emergency technology of application; common guardianship instrument using. Look: shock, cardiac respiratory arrest and acute organ failure, systemic inflammatory response syndrome and severe infection and multiple organ dysfunction syndrome (MODS), severe disturbance of body fluid environment such as critical theory and progress of the illness. 2. basic requirements (1) species and cases of study requirements: severe pneumonia in disease-disease myocardial infarction ... 3. high requirements (1) learning disease species: disease species disease species image radiation: rheumatic heart congenital heart intestinal Crohn's (Crohn) disease intestinal tuberculosis bile duct cancer chronic pancreatic inflammatory urinary system stone urinary system tumor adrenal disease thyroid disease cranial within infection nervous system tumor nuclear medical: Digest road bleeding explicit like brain blood flow perfusion explicit like testicular blood pool explicit like salivary glands explicit like (2) clinical knowledge, and skills requirements: understand various image check 氟尼辛葡甲胺的药代动力学特征是吸收迅速、排泄快，表观分布容积好、与血浆蛋白结合率高(99%)、易于在炎性部位聚集、生物利用度高，多种动物的静脉注射给药时数据符合二室开放模型。而且与血浆蛋白结合的氟尼辛葡甲胺很容易被同时使用的其它抗生素所置换。氟尼辛葡甲胺在体易代谢和消除，肝脏是主要代谢器官，代谢产物主要是4-羟基氟尼辛、5-羟基氟尼辛、2-甲羟基氟尼辛。给药后24h，约90%经尿液和粪便排出。 【药效学】 氟尼辛葡甲胺具有解热、消炎和镇痛作用，单独或与抗生素联合用药能够明显改善临床症状，并可以增强抗生素的活性。有人用小白鼠醋酸扭体法、家兔蛋白胨致热法观察氟尼辛葡甲胺的活性，结果都表明氟尼辛葡甲胺具有很好的解热和镇痛作用。 在我国兽医临床上主要用于马、牛、猪、猫、犬、羊等动物感染性疾病引起的发热及急性炎症，如马疝痛、内毒血症和骨骼肌肉紊乱;反刍动物乳房炎、肺炎、关节炎、内毒血症;猪子宫内膜炎、乳房炎和和无乳综合症;犬内毒素血症、腐败性腹膜炎、骨关节炎和骨骼肌肉紊乱。 【作用机制】 氟尼辛葡甲胺是环氧化酶的抑制剂，通过抑制花生四烯酸反应链中的环氧化酶，减少前列腺素和血栓烷等炎性介质的生成，通过维持正常血压、减轻血管内皮细胞的损伤、维持正常血容积等途径，阻止大肠杆菌内毒素引起呼吸道病中的支气管内渗出物增多、渗出物中嗜中性粒细胞、白蛋白聚集等多种途径, 有效缓解机体发热、炎症和疼痛。该药作用迅速，一般在15分钟内可减轻疼痛。效力比镇痛新、哌替啶、可待因更高，在治疗马跛行和关节肿胀方面效力是保泰松的四倍。 【制剂】(1)氟尼辛葡甲胺注射液(2)氟尼辛葡甲胺颗粒剂(3)氟尼辛葡甲胺糊剂 【贮藏】避光、密封保存 【有效期】3年 , 包装规格: application; infection and antibacterial drug of clinical application; transfusion refers to levy; nutrition support of adapted card and clinical application; common life support technology (as cycle breathing support, and nutrition support,) and emergency technology of application; common guardianship instrument using. Look: shock, cardiac respiratory arrest and acute organ failure, systemic inflammatory response syndrome and severe infection and multiple organ dysfunction syndrome (MODS), severe disturbance of body fluid environment such as critical theory and progress of the illness. 2. basic requirements (1) species and cases of study requirements: severe pneumonia in disease-disease myocardial infarction ... 3. high requirements (1) learning disease species: disease species disease species image radiation: rheumatic heart congenital heart intestinal Crohn's (Crohn) disease intestinal tuberculosis bile duct cancer chronic pancreatic inflammatory urinary system stone urinary system tumor adrenal disease thyroid disease cranial within infection nervous system tumor nuclear medical: Digest road bleeding explicit like brain blood flow perfusion explicit like testicular blood pool explicit like salivary glands explicit like (2) clinical knowledge, and skills requirements: understand various image check 产品的卖点: 齐鲁动保氟尼辛葡甲胺较同行所占的优势: 我公司产品除具有价格低、生产检测设备一流、售后服务好等优点外，质量好是绝对的竞争优势。 我公司氟尼辛葡甲胺色泽好、含量高、杂质少、有机残留低(无二氯甲烷、甲苯、乙酸乙酯等有机残留)，质量符合国家标准、USP31、EP(6.0)标准。我公司产品溶液澄清、颜色浅于标准规定，而国内绝大多数生产厂家均达不到EP(6.0)标准中的溶液颜色和澄清度的要求。 【氟尼辛葡甲胺的特点】 1.本品属于非甾体类解热镇痛药，没有使用激素(如地塞米松、氢化可的松等)带来的的副作用。 2.通过抑制环氧酶，减少炎性介质的生成来发挥解热、镇痛和抗炎作用。解热镇痛消炎效果确切，疗效好。对无论什么原因引起的发炎和发烧的临床症状都有很好的治疗和缓解作用。对下丘脑体温调节中枢无作用，因此不会使正常体温下降。不影响淋巴细胞的增殖和活化，无免疫抑制和减慢伤口愈合等副作用。 作用迅速，一般在15min内可减轻疼痛，比镇痛新、哌替啶、可待因、安3. 乃近、阿司匹林、氨基比林效力更高，且无成瘾性。 4.氟尼辛葡甲胺吸收迅速、排泄较快，表观分布容积大、生物利用度高。在血液中与血浆蛋白结合率高，因此药效持久。 5.氟尼辛葡甲胺给药形式多样，既可以口服，也可以肌肉注射或静脉注射。目前美国兽药典收载的剂型有注射液、糊剂、胶囊剂。 6.氟尼辛葡甲胺无“三致”作用(致畸、致癌、致突变)及繁殖毒性，安全性高，不易产生过敏及刺激反应。 7.与大多数抗生素联合用，能够极大的增强抗生素的活性，提高疗效，缩短疗程，并有效减少抗生素对动物机体的副作用。 产品质量保证---齐鲁兽药，真诚可靠～ 【质量标准】 application; infection and antibacterial drug of clinical application; transfusion refers to levy; nutrition support of adapted card and clinical application; common life support technology (as cycle breathing support, and nutrition support,) and emergency technology of application; common guardianship instrument using. Look: shock, cardiac respiratory arrest and acute organ failure, systemic inflammatory response syndrome and severe infection and multiple organ dysfunction syndrome (MODS), severe disturbance of body fluid environment such as critical theory and progress of the illness. 2. basic requirements (1) species and cases of study requirements: severe pneumonia in disease-disease myocardial infarction ... 3. high requirements (1) learning disease species: disease species disease species image radiation: rheumatic heart congenital heart intestinal Crohn's (Crohn) disease intestinal tuberculosis bile duct cancer chronic pancreatic inflammatory urinary system stone urinary system tumor adrenal disease thyroid disease cranial within infection nervous system tumor nuclear medical: Digest road bleeding explicit like brain blood flow perfusion explicit like testicular blood pool explicit like salivary glands explicit like (2) clinical knowledge, and skills requirements: understand various image check 项目 农业部标准 齐鲁兽药产品质量 性状 应为白色或类白色结晶性粉末 类白色结晶性粉末 酸碱度 7.0-9.0 7.0-9.0 熔点 137?-140? 137?-140? 比旋度 -9.0?- -12.0? -9.0?- -12.0? 干燥失重 ?0.5% ?0.5% 炽灼残渣 ?0.2% ?0.2% 有关物质 ?0.5% ?0.5% 含量测定 ?99.0% ?99.0% application; infection and antibacterial drug of clinical application; transfusion refers to levy; nutrition support of adapted card and clinical application; common life support technology (as cycle breathing support, and nutrition support,) and emergency technology of application; common guardianship instrument using. Look: shock, cardiac respiratory arrest and acute organ failure, systemic inflammatory response syndrome and severe infection and multiple organ dysfunction syndrome (MODS), severe disturbance of body fluid environment such as critical theory and progress of the illness. 2. basic requirements (1) species and cases of study requirements: severe pneumonia in disease-disease myocardial infarction ... 3. high requirements (1) learning disease species: disease species disease species image radiation: rheumatic heart congenital heart intestinal Crohn's (Crohn) disease intestinal tuberculosis bile duct cancer chronic pancreatic inflammatory urinary system stone urinary system tumor adrenal disease thyroid disease cranial within infection nervous system tumor nuclear medical: Digest road bleeding explicit like brain blood flow perfusion explicit like testicular blood pool explicit like salivary glands explicit like (2) clinical knowledge, and skills requirements: understand various image check