微量毒性蛋白质即可诱发脑部疾病

微量毒性蛋白质即可诱发脑部疾病 海量资料下载 免费学习英语 www.englishvip.com/xinlw.htm (申请网址) Neurodegenerative(神经变性的) diseases such as Alzheimer's could be better understood thanks to insight into proteins linked to such conditions, a study suggests. Scientists studying thread-like chains of protein -- called amyloid(淀粉体) fibres -- have found that low levels of these proteins may cause more harm to health than high levels. These rarely formed protein chains, which have been linked with dozens of diseases, are produced as a result of a genetic flaw or changes in body chemistry brought about by ageing. When this happens, short fibres are formed which become sticky and attract copies of themselves, forming an endless chain. These chains spontaneously break, creating morefilament(灯丝，细线) ends to which more proteins attach. In the context of neurodegenerative diseases, it is these short, broken pieces that seem to be most harmful, scientists say. Researchers have found that when protein levels are low, lots of short protein threads are formed. But when protein levels are high, this spontaneous breakage stops and most protein filaments remain long. Compared with harmful short protein fibres, long fibres do not appear to be damaging in the case of neurodegenerative diseases. Researchers therefore believe that high levels of the protein -- which lead to these longer chains -- may actually be protective. In addition to shedding light on disease, this insight into the protein chains may help scientists develop useful biomaterials, such as cell scaffolds, which are used for tissue engineering or to make artificial silk. Cait MacPhee, Professor of Biological Physics at the University of Edinburgh's School of Physics and Astronomy, said; "We would expect that the higher the level of toxins, the worse the disease. However, in this study we found that the lower the level of the protein, the more of these damaging short fibres we see. Understanding how these protein chains form offers us insight not only into how diseases progress, but how we can produce controlled biomaterials for tissue engineering." 神经变性(神经变性的)疾病，如阿尔茨海默氏症，可以更好地理解感谢洞察力成蛋白质与这样的条件 下，一项研究明。螺纹状链蛋白-所谓的淀粉样蛋白(淀粉体)纤维- 科学家研究发现，这些蛋白质水 平低可能会造成更大的健康危害比高水平。 这些很少形成的蛋白链，已与数十种疾病，是一种遗传缺陷或身体的化学变化所带来老化的结果。 洛基国际英语 竭诚为您服务 海量资料下载 免费学习英语 www.englishvip.com/xinlw.htm (申请网址) 当发生这种情况时，形成的短纤维变粘和吸引自己的副本，形成一个环形链。这些连锁店自发突破，创造更多的灯丝(灯丝，细线)结束，更多的蛋白质附着。 在神经退行性疾病的背景下，短，正是这些碎片，似乎是最有害的，科学家们说。 研究人员发现，当蛋白水平低，很多短蛋白质线程形成。但是，当蛋白质水平高，这自爆停止，并，大多数蛋白丝留长。 有害短蛋白纤维相比，长纤维不被损坏的神经变性疾病的情况下。因此，研究人员认为，高浓度的蛋白质 - 从而导致这些较长的链 - 可能实际上是保护。 除了对疾病的脱落光，这种洞察的蛋白质链可能会帮助科学家开发出有用的生物，如细胞支架，用于组织工程或人造丝。 CAIT麦克菲，在爱丁堡的物理学和天文学学院大学生物物理教授，说，“我们会想到的毒素的水平越高，疾病更糟糕。然而，在这项研究中，我们发现，较低的水平，蛋白质，这些有害短纤维我们看到。了解如何将这些蛋白质链的形式，为我们提供了洞察疾病的进展如何，只进不出，但我们如何能够控制生物材料，组织工程。“ “成千上万人疯狂下载。。。。。。 更多价值连城的绝密英语学习资料， 洛基内部秘密英语，技巧，策略 请在 网上 申请报名” 洛基国际英语 竭诚为您服务