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淘宝数据

2013-11-07 15页 ppt 598KB 49阅读

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淘宝数据nullnull Genetic Epidemiology M. Tevfik DORAK nullDisease characteristics: Familial clustering: Genetic or environmental: Mode of inheritance: Disease susceptibility loci: Disease susceptibility markers:Descriptive epidemiology Family aggregation studies Twin/adopt...
淘宝数据
nullnull Genetic Epidemiology M. Tevfik DORAK nullDisease characteristics: Familial clustering: Genetic or environmental: Mode of inheritance: Disease susceptibility loci: Disease susceptibility markers:Descriptive epidemiology Family aggregation studies Twin/adoption/half-sibling/migrant studies Segregation analysis Linkage analysis Association studiesGENETIC EPIDEMIOLOGY Flow of researchhttp://www.tjmes.com 铜球阀 截止阀 蝶阀 http://www.u51688.comnull * nuclear families (index case and parents) * affected relative pairs (sibs, cousins, any two members of the family) * extended pedigrees * twins (monozygotic and dizygotic) * unrelated population samplesStudy Designs in Genetic EpidemiologynullDisease characteristics: Familial clustering: Genetic or environmental: Mode of inheritance: Disease susceptibility loci: Disease susceptibility markers:Descriptive epidemiology Family aggregation studies Twin/adoption/half-sibling/migrant studies Segregation analysis Linkage analysis Association studiesGENETIC EPIDEMIOLOGY Flow of researchnullCurnow & Smith: J Roy Stat Soc 1975;138:139-169 Sibling Recurrence Risk / Sibling Risk Ratio (lS ) nullDisease characteristics: Familial clustering: Genetic or environmental: Mode of inheritance: Disease susceptibility loci: Disease susceptibility markers:Descriptive epidemiology Family aggregation studies Twin/adoption/half-sibling/migrant studies Segregation analysis Linkage analysis Association studiesGENETIC EPIDEMIOLOGY Flow of researchnull(MacGregor, 2000) nullAdoption Studies 1. Compare the risk in biological relatives with adopted relatives of affected adoptees (beware of adoption bias) 2. Compare the risk in biological relatives with adopted relatives of unaffected adopteesnullDisease characteristics: Familial clustering: Genetic or environmental: Mode of inheritance: Disease susceptibility loci: Disease susceptibility markers:Descriptive epidemiology Family aggregation studies Twin/adoption/half-sibling/migrant studies Segregation analysis Linkage analysis Association studiesGENETIC EPIDEMIOLOGY Flow of researchnullModes of inheritancenullDisease characteristics: Familial clustering: Genetic or environmental: Mode of inheritance: Disease susceptibility loci: Disease susceptibility markers:Descriptive epidemiology Family aggregation studies Twin/adoption/half-sibling/migrant studies Segregation analysis Linkage analysis Association studiesGENETIC EPIDEMIOLOGY Flow of researchnullDifferences between linkage and associationnullRisch NJ. Nature 2000nullDisease characteristics: Familial clustering: Genetic or environmental: Mode of inheritance: Disease susceptibility loci: Disease susceptibility markers:Descriptive epidemiology Family aggregation studies Twin/adoption/half-sibling/migrant studies Segregation analysis Linkage analysis Association studiesGENETIC EPIDEMIOLOGY Flow of researchnullAssociation Studies Population-based Cases and unrelated population controls from the same study base Family-based Child-family trios and TDT design is the most common
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