新品种抗生素或解决细菌的抗药性

海量下载 免费学习英语 www.englishvip.com/xinlw.htm （申请网址） University of Adelaide research has produced a potential new antibiotic which could help in the battle against bacterial resistance to antibiotics. The potential new antibiotic targets a bacterial enzyme critical to metabolic processes.   The compound is a protein inhibitor（抑制剂） which binds to the enzyme (called biotin生物素protein ligase), stopping its action and interrupting the life cycle of the bacteria.   "Existing antibiotics target the bacterial cell membranes but this potential new antibiotic operates in a completely different way," says Professor Andrew Abell, project leader and Acting Head of the University's School of Chemistry and Physics.   Professor Abell says the compound, although at a very early stage of development -- it has not yet been tested on an animal model -- has the potential to become the first of a new class of antibiotics.   "Bacteria quickly build resistance against the known classes of antibiotics and this is causing a significant global health problem," he says. "Preliminary results show that this new class of compound may be effective against a wide range of bacterial diseases, including tuberculosis which has developed a strain resistant to all known antibiotics."   Developing the new protein inhibitor involved a novel approach called 'in situ click chemistry'. A selection of small molecules, or 'precursor fragments', are presented to the bacteria in a way so that the target protein enzyme itself builds the inhibiting compound and also binds with it.   "In a sense the bacteria unwittingly（不知不觉地） chooses a compound that will stop its growth and assembles it -- like building a weapon and using it against itself," says Professor Abell. "We've gone a step further to specifically engineer the enzyme so that it builds the best and most potent weapon."   "Our results are promising. We've made the compounds; we know they bind and inhibit this enzyme and we've shown they stop the growth of a range of bacteria in the laboratory. The next critical step will be investigating their efficacy in an animal model."   "Thanks to this new approach what might have taken a year or more with a range of sequential experiments, we can now do in one single experiment," Professor Abell says.   The research has been published in the journal Chemical Science and is in collaboration with researchers at Monash University and Adelaide's Women's and Children's Hospital. 阿德莱德大学的研究已产生了潜在的新的抗生素，它可以帮助对抗细菌对抗生素产生抵抗力。新的抗生素的潜在目标一个细菌酶代谢过程中的关键。   该化合物是一种蛋白抑制剂（抑制剂）结合酶（称为生物素生物素蛋白连接酶），停止它的操作和中断细菌的生命周期。   “现有的抗生素针对的细菌的细胞膜，但这一潜在的新抗生素在一个完全不同的方式运作，说：”安德鲁·阿贝尔教授，项目负责人及大学的化学与物理学院署理系主任。   团Abell教授说的化合物，虽然在一个非常早期的发展阶段 - 它尚未经过测试的动物模型 - 有可能成为第一个一类新的抗生素。   “细菌快速构建抵抗已知的抗生素类，这是造成重大的全球性健康问题，”他说。初步的结果表明，这种化合物的一类新的可有效对抗广泛的细菌性疾病，已开发出所有已知的抗生素抗性菌株包括结核。   开发新的蛋白质抑制剂涉及一种新的方法被称为“原位点击化学”。精选的小分子，或“易制毒化学碎片”，对细菌，使靶蛋白的酶本身生成的抑制化合物，也与它结合的方式。   “从某种意义上说，细菌在不知不觉中（不知不觉地）选择一种化合物，将停止其增长和组装-像武器，对本身使用它，“阿贝尔教授说。“我们已经进了一步专门工程师酶，它建立最好和最有力的武器。”   “我们的业绩看好，我们所做的化合物，我们知道他们结合并抑制这种酶，我们已经证明他们停止生长的细菌在实验室范围内的一个关键步骤，将调查其在疗效动物模型“。   “由于这种新方法可能采取一年或一年以上的一个连续的实验范围，我们现在可以在一个单一的实验，”阿贝尔教授说。   这项研究已经发表在化学科学“杂志是在莫纳什大学和阿德莱德的妇女和儿童医院的研究人员合作。 “成千上万人疯狂下载。。。。。。 更多价值连城的绝密英语学习资料， 洛基内部秘密英语，技巧，策略 请在 网上 申请报名” 洛基国际英语 竭诚为您服务