[讲稿]随龄改变的人脑侧脑室宽度和室周白质：弥散张量成像能说明吗？

[讲稿]随龄改变的人脑侧脑室宽度和室周白质：弥散张量成像能说明吗？ 随龄改变的人脑侧脑室宽度和室周白质:弥散张量成像能说明吗, 脑室扩大已成为正常衰老和一些老化疾病阿尔茨海默病的生物标志。但目前需待明确和解决的问题是，人 类正常衰老过程中脑室扩大是否会影响大脑白质,韩国岭南大学医学院的Sang Seok Yeo博士所在课题组 希望以弥散张量成像检测说明这一问题。实验纳入60名20-78岁的健康人，应用弥散张量成像检测侧脑室 周白质的4个感兴趣区:前、后放射冠及胼胝体膝部和压部。应用脑室质量指数、侧脑室前角指数、侧脑 室后角指数评估脑室宽度，发现前后放射冠各向异性值和观弥散系数的增大与正常衰老过程中脑室扩大 相关，这些会影响脑室周围白质，并将进一步导致衰老过程中的认知和感觉运动功能减退。显示结果的文 章发表在《中国神经再生研究(英文版)》杂志2014年5月第9期。 Article: "Age-related changes of lateral ventricular width and periventricular white matter in the human brain: a diffusion tensor imaging study by Yong " 123Hyun Kwon, Sung Ho Jang, Sang Seok Yeo (1 Department of Physical Therapy, Yeungnam University College, Namgu, Daegu, Republic of Korea; 2 Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Namgu, Daegu, Republic of Korea; 3 Department of Physical Therapy, College of Health Sciences, Dankook University, Dongnam-gu, Cheonan-si, Chungnam, Republic of Korea) Kwon YH, Jang SH, Yeo SS. Age-related changes of lateral ventricular width and periventricular white matter in the human brain: a diffusion tensor imaging study. Neural Regen Res. 2014;9(9):986-989. 欲获更多资讯: Neural Regen Res Age-related changes in lateral ventricular width and periventricular white matter by DTI Ventricular enlargement has been suggested as a structural biomarker for normal aging and progression of some illnesses, such as Alzheimer’s disease. However, the question of how this structural change in the brain in normal elderly affects change of white matters remains a topic of interest and concern. Dr. Sang Seok Yeo, College of Medicine, Yeungnam University, Republic of Korea, and his team performed a diffusion tensor imaging (DTI) study to investigate the question. They detected four regions of interest in the periventricular white matter of 60 normal subjected aged 20-78 years using DTI technique: the anterior corona radiata, the posterior corona radiata, and the genu and splenium of the corpus callosum. They also assessed ventricular width using ventricular body index, anterior horn index, and posterior horn index, and found that the increase of fractional anisotropy value and apparent diffusion coefficient value of the anterior and posterior corona radiata appear to be related to enlargement of the ventricle by normal aging. Consequently, these effects on periventricular white matter might show correlation with cognitive and sensory motor deficits by aging. These results were published in Neural Regeneration Research (Vol. 9, No. 9, 2014). Article: "Age-related changes of lateral ventricular width and periventricular white matter in the human brain: a diffusion tensor imaging study by Yong " 123Hyun Kwon, Sung Ho Jang, Sang Seok Yeo (1 Department of Physical Therapy, Yeungnam University College, Namgu, Daegu, Republic of Korea; 2 Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Namgu, Daegu, Republic of Korea; 3 Department of Physical Therapy, College of Health Sciences, Dankook University, Dongnam-gu, Cheonan-si, Chungnam, Republic of Korea) Kwon YH, Jang SH, Yeo SS. Age-related changes of lateral ventricular width and periventricular white matter in the human brain: a diffusion tensor imaging study. Neural Regen Res. 2014;9(9):986-989.