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β2-糖蛋白Ⅰ及抗磷脂抗体与复发性流产的关系研究

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β2-糖蛋白Ⅰ及抗磷脂抗体与复发性流产的关系研究 . . ? P ? ? ? ?。 ? ? 20l o Dec;27(6)974 JOURNAI OFGUANGXI MEDICAI UNIVERSITY? ? , 132????I?????????????????。 ???????? ?? (?????????210029) ??? B2???I;?????;????? ?????:R714.21 ?????:A ????:1005?930X(2010)06?0974?03 ?????( recur rent s pont aneous abort i on,...
β2-糖蛋白Ⅰ及抗磷脂抗体与复发性流产的关系研究
. . ? P ? ? ? ?。 ? ? 20l o Dec;27(6)974 JOURNAI OFGUANGXI MEDICAI UNIVERSITY? ? , 132????I?????????????????。 ???????? ?? (?????????210029) ??? B2???I;?????;????? ?????:R714.21 ?????:A ????:1005?930X(2010)06?0974?03 ?????( recur rent s pont aneous abort i on,RSA) ?? ??2?????????。???????、??、?? ?、?????,?????RSA??????( ant i phos? phol i pi n ant i bodi es,APA)??,???????( ant i phos? phol i pi d syndr ome,APS)??????????。APA? ??????;?????????,???RSA???? ??????????(ant i car di ol i pi d ant i bodi es,ACA) ;? ?????????????。??????????B2? ???I (62?gl ycoprot ei n I,62?GP I) 、???、???、?? C、?????C、??S、????A5、????????、 ???????、????????????????。? ?????132?GP l ?APA?????????。???? ????,???????[ 1。]。APA????????? ???????????????致??。?????? ???????、????、??????RSA?。APA? ???RSA????????。??APA?RSA??? ??????????,???APA??????B2?GP I ?RSA?????????。 1 p2?GP I?? 132?GPIX?????H,??????。?????50 ku ??????。82?GP I??326??????,??5?? ??,???5?????????????????? ?,??????( Ser ) 31l ????( Lys) 317?7???? ???????,?????????,???62?GP 1?? ????????????。62?GP I???????? ?,????62?GP I????????,???????? 62?GP I???????????。???62?GP I??? ?????????????????,???????? ???????.???FX,FⅪ???。????62?GP l ??????C?????????Z???????? ???㈨。B2,GP 1??????????、?????? ???,?????????????????????? *????:??????????????(No.I J 200910) ?????.?????????? 210029 ????:zol o?07?13 ?????J。 2 132?GP I??p2?GP I??( ant i?bet a2? gl ycoprot ei n I ant i body,a nt i ?132GP I Ab)?? ????RSA?????? ????????ant i?132C- P I Ab????,62?GP I? ?致?.?????B2?GP I???????.?????? ????????????。???ant i?132GP I Ab?? ?,?62?GP l ??.?????????62?GP I????。 ??62?GP I?????????????,???致?? ??????。??62?GP I?????,?ant i?/32GP I Ab ????62?GP l ?????????,???????? ????APA????B2?GP l ?,??????“??? ?”:??????????62?GP 1?????????? ??。?????????。????62?GP I?????], ?????????????。????????APA? ??????。???p2?GP 1????????,???? ???????m】。 ??????:a nt i?132GP I Ab????????C? ???V( FV),??????,????????,??? ??????????????( LDI,)。???????? ?????’8]。??????,????ant i?i 32GP I Ab? APS???????、RSA??????。ant i ?182GP 1 Ab ??62?GP I???????,??????????Ⅱ? ??????,??????????(NF)?l oB????? ????????.????????、????、??? ?/???????????,???????????? ????[ 9]。??????????,62?GP I????? ????????????62?GP I???APA(??ant i ? 132GP I Ab)?????。??????p2?GP I ?ant i ?B2GP I Ab??????????????????。???? ??p2-G.P I?ant i ?I ]ZOP I Ab???????HCG?? ?.????????????。??????????? ?[ 1?。??????APS?????????????? ????,????????,62?GP l ????????? ????????[ J“。??????????????? ant i?l B2GP 1 Ab?/s2?GP I?????????????? ?????,???????????????,??HCG ??。?.B2????l ????????????????? ?975? ???。?????????致????,????致?? ??。??B2?GP I?ant i?I ]2GP I Ab????????? ????Z?????,??????A5??????? ??????????.?致??????。?????? ????【1“。 3 | 32?GP I?ACA??????RSA?? ???? APA??ACA?????。??????????? ???????????????。????????。 ACA?????????????B2?GP 1?????[ I“。 ????????????????。???????B2? GP I???????????。???????????。 ?2?GP I????ACA?RSA??????。ACA??? ????????????:①???????????? ???,?????、???????,????????? ???,????????????。????????? ?HCG、HPI。????。②??????A2????? ????,?致?????。?????。??????。? ???????。③????????????????, ?????????????,???????,???? ????。致??????营??????。④????? ???????V???(??????????V???? ????????????)。????C( Pr ot ei n C)?? ?.??????Ⅲ(Ant i t hr ombi nU1)???。????? ?????????????( VCAM- 1)???????? ?( I cAM?1)?????,???致????。?ACA?? ??B2?GP I ??,?p2?GP I???????????? ?,?ACA??2?GP 1???。?????????,?致 B2?GP I???????????。?????????? 致?????,???????。?????????,?? ??????,???致??????。?82?GP I??? ??????????????????ACA[ 1“。Bl ank ?『l????????B2?GP I????,???????? ???ACA,???????????????、???? ????????????????。 4 APA?RSA?????? ????????ACA????????????? ???????????。ACA- EI。I SA???????? ?????RSA??????????,?ACA?EI。I SA? ????????????。ACA?????????? ?????【1 6“?,???????ACA???????, ?????????,?????ACA?El 。I SA????? ?????????????????,?致?????? ??????,?????Oal l i ?[1 9]??。 ??????B2?GP l?APS?????。???? ???? ??ant i ?132GP I Ab???ACA??????。 ant i ?I ] 2GP I Ab?RSA????,??????l gG?? ?,????ant i ?p2GP 1 Ab?ACA???APA?RSA? ??????[ 2?。??APS??ACA???,?ant i? 132GP I Ab???。ant i?B2GP I Ab??????pZ- GP I? ????ACA???????。?2006??11??? APS??????。??APA???????????? ????。??????????ant i ?B2GP l Ab???? ???APS??????“。??ant i ?B2GP 1 Ab???? ???RSA??????。????ant i?I ] 2GP I Ab EI。I SA??????????,???ant i ?f 12GP l Ab?? ?????????ant i ?B2GP l Ab EI。I SA????,?? ???ant i ?p2GP 1 Ab EI。ISA??????。?ant i ?p2GP I Ab El ,ISA??????:??L????、?????、?? ???、??????、??????????。???? ant i ?i 32GP I Ab???????????????。??? ?????????????( pl asmin)。?????( ant i ? pl a smi n Ab)?RSA??。?ant i ?pl asmi n Ab?????? ???RSA????????,?????????? ?‘2“。 5????APA??????????? ? ???????APA?RSA???,??????? ??APA???????????。????APA?? ?????????????:???????????? ??????;??????????。??T???APA ?致????????;??????????????? ??????。??????APA?,??????,?? ?致????;?????????????,????? ??????????,??APA?????????? ?,2“。????????????、??、??。???? ?、??,???????????????,?????? ??,???????????。 6 ? ? ??,????APA?RSA??????????? ??????,B2?GP l??APA?????,???APA ????????????????。????I ] 2- GP I? APA?RSA????????????。???APA?致 ?RSA??????????。??????APA?致? RSA?????????,????????,APA??? ???????????????致?????“。?? APA????????,??????????????。 ??APA?RSA??????,??ant i ?132GP I Ab?? ?????????????APA?????????? ????????。???????????????? ???APA?致?RSA???????? ?。 ?976? ????????2010 De c;27(6) ????: [ 1 1 Bi l l Gi annakopoul os,Freda Pa ss am,Sohe i l a Rahgozar , et a1.Cur r ent concept s on t he pa t hogenesi s of t he an? t i phosphol i p i d syndr ome[J ].Bl ood,2007,109(2):422? 430. [ 23 We i?Shi ang I,i n.Some ant i phosphol i pi d ant i bodi es re c? ogni z e conforma t i ona l epi t opes share d by p2GPI and t he homol ogous cat al yt i c domani s of sever a l ser i ne pr ot ea? se s[ J] .Ar t hr i t i s Rheum。2007。6(5):1 638?1 647. [ 3] For ast i e r o RR。Mar t i nuzzo ME。Lu L。e t a1.Aut oi m? mune ant i phosphol i pi d ant i bo di es i mpai r t he i nhi bit i on of act i vat ed f act or Xby pro t ei n Z/pr ot ei n Z-dependent pro t ea se i nhi bi t or [J ] .Throm- b Haemost 。2003,1(8) : 1 764-1 770. [ 4] Bas de La at 。Koen Mer t ens,Phi l i p Gde Gr oot.Mecha? ni sms of Di sease: an t i phosphol i pi d ant i ?bodi es?f r om c li ni c al asso ci at i on t o pat hol og i c mechani sm[ J] .Rheu? mat ol ogy。2008,4( 4):19 2?199. [ 5] Lut t e r s BC,Mej i er s JC,Derksen RH,e t a1.Dimer s of bet a2?- gl ycopr ot ei n I mi mi c t he in vi t r o ef f ect s of bet a 2?? gl ycoprot ei n I -a nt i??be ta 2?‘gl ycopr ot ei n I ant i body cor n。? pl exes [ J] .Bi ol Chem。2001,276:3 060?3 067. [ 6] Mer r i l l JT.What ca use s t he ant i phosphol i p i d s yndr ome [ J1.Cur r Rheumat ol Rep,2001,3 ( 4):293?300. [ 7]Kobayashi K,Mat suura E,Li u Q,et a1.A speci f i c l i g? and f or bet a 2- g l ycoprot e i n 1 medi at e s aut o ant i body- de? pendent upt ake of oxi di z edl ow densi t y l i popr ot ei n by macr ophage s[J ].Li pi d Res,2001,42:697?709. 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