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欢迎网上投稿 ? 1034?中国药理学通报ChinesePharmacologicalBulletin2006Sep;22(9) Rev.1995.146(1):5一I9. [21]ZoeteweijJP.VandeWaterB,deBontHJ,eta1.Calcium-in- ducedcytotoxicityinhepatocytes'afterexposuretoextracellular ATPisdependentoninorganicphosphate.Effectsonmitochondri— alcalcium[J].JBiolChem.1993,268(5):3384—8. f22]ChvatchkoY,ValeraS,AubryJP,eta1.Theinvolvementofan ATP-gatedionchanne1.P2Xl,inthymocyteapoptosis[J]lmmu— nity,1996.5(3):275—83. [23]MaaserK,HopfnerM.KapH,eta1.Extracellularnucleotidesin— hibitgrowthofhumanoesophagealcancercellsviaP2Y2-receptors [J].曰rJCancer,2002,86(4):636—44. [24]HopfnerM,MaaserK.BarthelB,eta1.Growthinhibitionand apoptosisinducedbyP2Y2receptominhumancolorectalcarcino- macells:involvementofintracellularcalciumandcyclicadenosine monophosphate[J].1mJColorectalDis,2001,16(3):154—66. [25]KoshibaM,ApasovS.SverdlovV,eta1.Transientup—regulation ofP2Y2nucleotidereceptormRNAexpressionisanimmediateear- lygeneresponseinactivatedthymocytes[J].ProcNatlAcadSci USA,1997,94(3):831—6. [26]JiangS,KullB,FredholmBB.eta1.P2Xpurinoceptorisnot importantinthymocyteapoptosis[J].1mmunolLett,1996,49(3): l97—201. [27]HenkartPA.ICEfamilyproteases:mediatorsofallapoptoticcell deathlJj.Immunity,1996.4(3):195—201. [28]SchrierSM,FloreaBI,MulderGJ,eta1.Apoptosisinducedby extracellularATPinthemouseneuroblastomacelllineN1E.115: studiesoninvolvementofP2receptorsandadenosine『J].Biochem Pharrr~tcoZ,2002,63(6):1119—26. [29]BurnstockG.Purinergicsignalingandvascularcellproliferation anddeath[J].ArteriosclerThrombVascBiol,2002,22(3):364— 73. [30]SabalaP,CzajkowskiR,P~ybylekK,eta1.TwosubtypesofG protein-couplednucleotiderecepto~,P2YlandP2Y2areinvolved incalciumsignallingingliomaC6cells[J].曰rJPharmaco1. 2001.132(2):393—402. [31]CzajkowskiR,LeiL.SabalaP,eta1.ADP-evokedphospholipase CstimulationandadenylylcyclaseinhibitioningliomaC6cellsoc- curthroughtwodistinctnucleotidereceptors,P2YlandP2Yl2 [J].FEBSLett,2002,513(2—3):179—83. [32]MayerC,KamleiterM.Sanchez-BrandelikR,eta1.Neuroligand- mediatedcalciumsignalinginculturedhumanschwannomacells [J].JPeripherNervSyst,1999,4(2):99—105. [33]NearyJT,RathboneMP,CattabeniF,eta1.Tmphicactionsof extracellularnucleotidesandnucleosidesonglialandneuronal cells[J].Trend.~Neurosci,1996,19(1):13—8. Apoptosisrelatedwithextracellularadenosinetriphosphate andadenosineandtheirpurinergicreceptors WANGMing—xia,RENLei—ming,WANGHong—fang (1.TheFourthAffiliatedHospital,HebeiMedicalUniversity,Shifiazhuang050011,China;2 .SchoolofPharmacy, HebeiMedicalUniversity,Shijiazhuang050017,China;3.ZhongrunPharmaceuticalCorpo ration,Shijiazhuang050011,China) Abstract:Extracellularadenosinetriphosphate(ATP) andadenosineareimportantsignalingmoleculesin bothintracellularandextracellularmicroenviromentsof cells.Theyexertcytoxicandapoptoticeffectsinsome tissuessuchastumor.Theproapoptoticmechanismsof adenosineanditsreceptorsareinvolvedinAdenylyl cyclase(AC),cAMP,Ca",etc.Apoptosisinduced byATPisassociatedwithseveralpurinergicreceptors includingP2X1,P2X2,P2X7,P2Y1,P2Y2,etal,it isalsoinvolvedinFasL/FasR,Tcellreceptor(TCR), andgeneregulationsofbcl一2andbax. Keywords:adenosinetriphosphate;adenosine;apop— tosis;purinergicreceptors ?本刊启事? 欢迎网上投稿 《中国药理学通报》欢迎网上投稿,投稿信箱为:zgylxtb8@163.COB.单位证明信和 稿件处理费(公费 100元,自费50元)需从邮局寄至:230032合肥市安徽医科大学校内《中国药理学 通报》编辑部. 修回稿电子版发送至修回稿信箱(zgylxtb88@163.COB),原稿及修回稿打印稿等 请邮寄到本刊编辑部. 本刊的稿件查询信箱为:zgylxtb@163.COB