脑脊液途径移植神经干细胞治疗中枢神经系统疾病的研究现状

脑脊液途径移植神经干细胞治疗中枢神经系统疾病的研究现状 ，，，，，，，12121131213131张宝华，仇福成，董 慈，韩 瑞，张永志，刘惠苗，解冰川，张丽娜 ，，，，，21223131232，王文婷，王彦永，张振清，顾 平，闫宝勇 123河北医科大学第一医院，老年病科，河北省脑老化与认知神经科学重点实验室，神经内科，河北省石 家庄市 050031 Neural stem cell transplantation for central nervous system diseases via the cerebrospinal fluid 1, 2, Qiu Fu-cheng1, 2, Dong Ci1, Han Rui1, 3, Zhang Yong-zhi1, 2, Liu Hui-miao1, 3,Xie Zhang Bao-hua Bing-chuan1, 3, Zhang Li-na1, 2, Wang Wen-ting1, 2, Wang Yan-yong2, 3, Zhang Zhen-qing1, 3, Gu Ping 1, 2, 3,Yan Bao-yong2 12Department of Gerontology, Brain Aging and Cognitive Neuroscience Laboratory of Hebei 3Province, Department of Neurology, First Affiliated Hospital of Hebei Medical University, Shijiazhuang 050031, Hebei Province, China 摘要 背景:目前报道的用于神经干细胞移植的途径主要有经局部病变部位途径、经血液循环途径及 经脑脊液循环途径3种。 目的:综述经脑脊液途径移植神经干细胞或神经前体细胞的方式及其在治疗中枢神经系统疾病 中的应用。 方法:检索Pubmed数据库和CHKD全文数据库2000至2009年相关文献，叙述脑脊液途 径移植神经干细胞的方法、在动物实验和临床方面治疗中枢神经系统疾病的应用及治疗机制 。 结果与结论:脑脊液适宜神经干细胞的存活、增殖、分化，经脑脊液途径移植神经干细胞治疗 中枢神经系统疾病是一种有效可行的方法。但因神经干细胞的来源问题及治疗的机制、最佳时 间窗和数量、安全性等诸多问题，仍需更深更广的研究，从而为蛛网膜下腔注射神经干细胞治 疗中枢神经系统疾病奠定坚实的基础。 中国组织研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤 干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程 全文链接: 关键词 : 干细胞; 神经干细胞; 细胞移植; 脑室; 脑脊液; 移植途径; 中枢神经系统; Abstract: BACKGROUND: Currently, neural stem cell transplantation can be performed through three main approaches: local lesions, blood circulation, and cerebrospinal fluid. OBJECTIVE: To review the transplantation of neural stem cells or neural precursor cells via the cerebrospinal fluid in the treatment of central nervous system diseases. METHODS: A computer-based search of PubMed and CHKD databases was performed to retrieve articles concerning transplantation of neural stem cells via the cerebrospinal fluid, and its application and therapeutic mechanism in the treatment of central nervous system diseases in both animal experiment and clinic study published from 2000 to 2009. RESULTS AND CONCLUSION: It is suitable for neural stem cell survival, proliferation, and differentiation in the cerebrospinal fluid. Transplantation of neural stem cells via the cerebrospinal fluid is effective and feasible to treat central nervous system diseases. However, some problems have not been solved, such as the source of neural stem cells, the optimal time window and cell dose, the safety and the long-term effect. Further studies are needed to pave the way for the intrathecal injection of neural stem cells in the treatment of central nervous system diseases. 中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤 干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程 全文链接: Key words: central nervous system diseases; stem cells; neural stem cells; stem cell transplantation; drug administration routes; 中图分类号: R318 基金资助: 河北省重大攻关课题(12276102D) 通讯作者: 顾平，硕士生导师，河北医科大学第一医院，老年病科，神经内科，河北省脑老化 与认知神经科学重点实验室，河北省石家庄市 050031 作者简介: 张宝华，主要从事神经干细胞分化研究。 引用本文: 张宝华,仇福成,董 慈等. 脑脊液途径移植神经干细胞治疗中枢神经系统疾病的研究现状[J]. 中国组织 工程研究, 2014, 18(6): 974-978.