SVHC-07 五氧化二砷 Diarsenic Pentaoxide_publication(C 致癌)

SVHC SUPPORT DOCUMENT Substance name: Diarsenic Pentaoxide EC number: 215-116-9 CAS number: 1303-28-2 MEMBER STATE COMMITTEE SUPPORT DOCUMENT FOR IDENTIFICATION OF DIARSENIC PENTAOXIDE AS A SUBSTANCE OF VERY HIGH CONCERN Adopted on 1 October 2008 SVHC SUPPORT DOCUMENT 1 CONTENTS DIARSENIC PENTAOXIDE.......................................................................................................................................1 AS A SUBSTANCE OF VERY HIGH CONCERN ....................................................................................................1 JUSTIFICATION .........................................................................................................................................................3 1 IDENTITY OF THE SUBSTANCE AND PHYSICAL AND CHEMICAL PROPERTIES .................................3 1.1 Name and other identifiers of the substance ...................................................................................................3 1.2 Composition of the substance .........................................................................................................................3 1.3 Physico-chemical properties ...........................................................................................................................4 2 CLASSIFICATION AND LABELLING ...............................................................................................................4 2.1 Classification in Annex I of Directive 67/548/EEC........................................................................................4 REFERENCES .............................................................................................................................................................5 TABLES Table 1: Summary of physico- chemical properties .....................................................................................................4 SVHC SUPPORT DOCUMENT 2 Substance Name: Diarsenic Pentaoxide EC Number: 215-116-9 CAS number: 1303-28-2 • The substance is identified as a CMR according to Article 57 (a) of Regulation (EC) No 1907/2006 (REACH). Summary of the evaluation: According to Annex I to Directive 67/548/EEC Diarsenic Pentaoxide is classified as a carcinogenic Carc.Cat 1 (R 45: May cause cancer). SVHC SUPPORT DOCUMENT 3 JUSTIFICATION 1 IDENTITY OF THE SUBSTANCE AND PHYSICAL AND CHEMICAL PROPERTIES 1.1 Name and other identifiers of the substance Chemical Name: Diarsenic Pentaoxide EC Name: 215-116-9 CAS Number: 1303-28-2 IUPAC Name: 1,3-dioxodiarsoxane 1,3-dioxide 1.2 Composition of the substance Chemical Name: Diarsenic Pentaoxide EC Number: 215-116-9 CAS Number: 1303-28-2 IUPAC Name: 1,3-dioxodiarsoxane 1,3-dioxide Molecular Formula: As2O5 Structural Formula: Molecular Weight: 229.84 Typical concentration (% w/w): >= 99 Concentration range (% w/w): See typical concentration SVHC SUPPORT DOCUMENT 4 1.3 Physico-chemical properties Table 1: Summary of physico- chemical properties REACH ref Annex, § Property IUCLID section Value VII, 7.1 Physical state at 20°C and 101.3 kPa 4.1 VII, 7.2 Melting/freezing point 4.2 315° C VII, 7.3 Boiling point 4.3 VII, 7.5 Vapour pressure 4.6 VII, 7.7 Water solubility 4.8 1.5 Kg (16° C) VII, 7.8 Partition coefficient n- octanol/water (log value) 4.7 partition coefficient XI, 7.16 Dissociation constant 4.21 2 CLASSIFICATION AND LABELLING 2.1 Classification in Annex I of Directive 67/548/EEC Diarsenic pentaoxide has been classified according to the 19th ATP, updated in the 25th ATP, of Directive 67/548/EEC as Carc. Cat. 1; R45 (May cause cancer) - T; R23/25 (Toxic by inhalation and if swallowed) - N; R50-53 (Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment ) and has been included in the Annex I of the Directive 67/548/EEC under index number: 033-004-00-6. Safety phrases: • S53: Avoid exposure - obtain special instructions before use. • S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). • S60: This material and its container must be disposed of as hazardous waste. • S61: Avoid release to the environment. Refer to special instructions/Safety data sheets. SVHC SUPPORT DOCUMENT 5 REFERENCES ECB ClassLab database http://ecb.jrc.it/classification-labelling/search-classlab/ Fiche toxicologique de l’INRS FT192 : Arsenic et composés minéraux. 2006 Annex I of the Directive 67/548/EEC INERIS - Fiche de données toxicologiques et environnementales des substances chimiques : Arsenic et ses dérivés inorganiques. 2006 INRS – Inventaire 2005 des agents CMRS : Pentaoxide d’Arsenic [1303-28-2] INRS – Fiche toxicologique FT192, Arsenic et ses composés minéraux, 2006