血压控制目标

Blood Pressure Control in Chronic Kidney Disease:Is Less Really More Blood Pressure Control in Chronic Kidney Disease:Is Less Really More? 慢性肾脏病血压控制：越低越好？ Journal of the American Society of Nephrology,Vol.0021,Issue 007,Page 1086 美国肾病学会杂志 ABSTRACT BP control is critical in the treatment of patients with chronic kidney disease.Recent guidelines now recommend a BP goal of 130/80 mmHg. Clinical trials using a randomized, intention-to-treat design have not established the benefits of this goal; rather, observational data and secondary or subgroup analyses drove the development of the new guidelines. A variety of observations suggest potential adverse events associate with achieving too low a BP in patients with chronic kidney disease, and ongoing randomized trials will have to establish the benefits or risks of meeting this goal. 血压控制在慢性肾脏疾病病人的治疗中至关重要。最新指南建议血压控制目标为130/80 mmHg。临床试验采用随机、意向性治疗设计还没有论证这一目标的收益。相反，观测数据和分组分析带动了新的指南。一个大样本的观测研究提示，慢性肾脏疾病患者血压控制于过低水平与潜在的不利事件相关，正在进行的随机试验将必须确认达到这一目标的收益或风险。