几丁质结合蛋白介绍

几丁质结合蛋白介绍Aroleforvariableregion-containing包含多个结构域chitin-bindingproteins几丁质结合蛋白(VCBPs)inhostgut–bacteriainteractions宿主肠道细菌相互作用Anumberofdifferentclassesofmolecules许多不同种类的分子，functionasstructuralmatrices起到结构矩阵的作用foreffecting以影响innateandadaptiveimmunity.先天和后天免疫Themostextensively最普遍的characterized特征性mediators中介者ofadaptiveimmunity获得性免疫aretheimmunoglobulins免疫球蛋白andT-cellantigenreceptorsT细胞抗原受体foundinjawedvertebrates.有颚（颌类）脊椎动物Inbothclassesofmolecules,在两种分子中uniquereceptorspecificity特异性受体专一性iseffectedthroughsomaticvariation通过体细胞变异实现inthevariable(V)结构域structuraldomain.Vregion-containingchitin-bindingproteins包含V结构域的几丁质结合蛋白(VCBPs)consistof由...构成twotandem两个串联的Ig免疫球蛋白Vdomainsaswellasachitin-bindingdomain.和一个几丁质结合结构域VCBPsareencodedatfourloci(i.e.,VCBPA–VCBPD)inCiona,aurochordate,andareexpressedbydistinctepithelialcellsofthestomachandintestine,aswellasbygranularamoebocytespresentinthelaminapropriaofthegutandincirculatingblood.VCBPsaresecretedintothegutlumen,anddirectbindingtobacterialsurfacescanbedetectedbyimmunogoldanalysis.Affinity-purifiednativeandrecombinantVCBP-C,aswellasaconstructconsistingonlyofthetandemVdomains,enhancebacterialphagocytosisbygranularamoebocytesinvitro.VariousaspectsofVCBPexpressionandfunctionsuggestanearlyoriginforthekeyelementsthatarecentraltothedialoguebetweentheimmunesystemofthehostandgutmicroflora.bacteriaopsonization|bacteriaphagocytosis|immunoglobulinvariabledomains