非酒精性脂肪性肝论文：非酒精性脂肪性肝 保肝消脂颗粒 肿瘤坏死因子-a

非酒精性脂肪性肝论文：非酒精性脂肪性肝 保肝消脂颗粒 肿瘤坏死因子-a 非酒精性脂肪性肝论文:非酒精性脂肪性肝 保肝消脂颗粒 肿瘤坏死因子-a 【中文摘要】观察保肝消脂颗粒对非酒精性脂肪肝患者肝郁脾虚痰浊血瘀证的临床疗效和血清肿瘤坏死因子-a水平的影响。方法:本研究采用随机、阳性药对照的试验方法,将80例非酒精性脂肪性肝的患者随机分为两组,每组各40例。两组一般治疗相同(调畅情志合理饮食,适当运动),治疗组在一般治疗的基础上采用保肝消脂颗粒治疗,对照组在一般治疗的基础上采用水飞蓟宾胶囊治疗,疗程均为八周,观察两组患者治疗前后临床症状、肝功、血脂、肝脏B超声像图的变化及治疗前后的TNF-a水平的变化。结果:?两组的肝功、血脂及患者的B超现较治疗前均有下降,统计学有差异(P0.05);?两组治疗后的TNF-a水平均比治疗前下降,有统计学差异(P0.05);?治疗组和对照组的中医症候积分比较治疗前后均有统计学意义(P<0.05),治疗组治疗后的中医症候积分与对照组治疗后相比具有统计学意义(P<0.05)。结论:保肝消脂颗粒可以改善非酒精性脂肪肝患者的临床症状、肝功、血脂和肝脏B超图像表现,可以下调TNF-a水平,保肝消脂颗粒治疗非酒精性脂肪肝患者肝郁脾虚痰浊血瘀证临床症状改善优于水飞蓟宾胶囊,且安全性良好。 【英文摘要】Purpose:the study of the treatment on non-alcoholic fatty liver of stagnation of liver-QI and deficiency of the spleen and blood stasis wet chaotic syndrome with using Baoganxiaozhi granule by observing the clinical effect and the change of the TNF-a before and after the treatment.Method:The protocol for this study including 80 patients with NAFLD was employed,which was accorded to the income standard.The patients were randomized into two groups,The basic treatment of two groups is the same.The patients took Baoganxiaozhi granule in treatment group,while 40 cases of the control group took the Shuifeijibin capsule.The period of treatment was 4 weeks in each group.The situation of patients were observed and compared,including the clinical syndrome and the change of TNF-a.Result:?fter the treatment,there was no significant difference of liver functions testing,Blood lipid between the two groups (P>0.05),but in both two groups there were significant difference before and after the treament (P>0.05);?And the type-B ultrasonic and TNF-a had changed after the treatment (P0.05);?But the change of the clinical syndrome score in treatment group was significant to the control group(P<0.05),and both had ignificant difference after the treament(P<0.05).Conclusion:The clinical observation of the groups of Baoganxiaozhi granule and Shuifeijibin capsule proves that Baoganxiaozhi granule and Shuifeijibin capsule both can improve clinical syndromes and relieve the degree of seriousness with type-B ultrasonic checking.and TNF-a had plummeted,And the treament group was better than the control group in the clinical syndrome score in Stagnation of liver-QI and deficiency of the spleen and blood stasis wet chaotic syndrome, The clinical study was good safety. 【关键词】非酒精性脂肪性肝 保肝消脂颗粒 肿瘤坏死因子-a 【英文关键词】nonalcoholic fatty liver disease Baoganxiaozhi granule TNF-a 【】保肝消脂颗粒对非酒精性脂肪肝患者血清TNF-α影响 的临床研究 缩略语表 4-5 中文摘要 5-6 ABSTRACT 6 前言 7-8 文献综述 8-31 1 祖国医学对非酒精脂肪肝的认识 8-23 1.1 病 因病机 8-10 1.2 辨证分型 10-11 1.3 中医治疗 11-22 1.4 前景与展望 22-23 2 现代医学对非酒精性 脂肪肝的认识 23-28 2.1 发病原因 23-24 2.2 发病机 制 24-25 2.3 西医治疗 25-28 3 肿瘤坏死因子-a与非 酒精性脂肪肝的研究进展 28-31 临床研究 31-36 1 一 般资料 31 2 诊断 31-33 3 纳入标准 33 4 排除标准 33-34 5 剔除标准 34 6 研究方法 34-35 7 统计分析 35-36 结果 36-39 1 疗效分 析 36-38 2 安全性分析 38-39 讨论 39-43 1 立 法依据 39 2 组方原则 39-40 3 现代药理研究 40-42 4 治疗作用 42-43 结论 43-44 致谢 44-45 参考文献 45-53 个人简历 53 【采买全文】 1.3.9.9.38.8.4.8 1.3.8.1.13.7.2.1 同时提供论文写作定制和论文发表服务.保过包发. 【说明】本文仅为中国学术文献总库合作提供，无涉版权。作者如有异议请与总库或学校联系。