【精品】主要学习与工作经历60

【精品】主要学习与工作经历60 易凡，男，1972年12月生。博士，教授，博士生导师。美国生理学会和美国药理学会会员。1996年毕业于山东大学化学院获学士学位，1999年在中国科学院化学研究所获得硕士学位后赴美国继续深造，先后在加利福尼亚大学戴维斯分校，威斯康星大学麦迪逊分校药学院，威斯康星医学院就读，于2003年获得药学硕士学位和2005年底获得药理学博士学位。2006年继续在弗吉尼亚州立大学医学中心从事相关领域的研究。 研究方向主要集中在心血管病和肾脏病的发病机理以及相关的心，肾，血管细胞的信号传导机理和分子细胞药理学的研究。2008年9月被山东大学医学院药理学研究所聘为教授，博士生导师。 主要学习与工作经历 2008.9-至今 山东大学医学院 教授、博士生导师 2005.12-2008.8 美国弗吉尼亚州立大学，药理系 Postdoctoral Research Associate 2005. 12 美国威斯康星医学院 博士 2003. 08 美国威斯康星大学麦迪逊分校药学院 硕士 1999.07 中国科学院化学研究所 硕士 1996.07 山东大学化学院 学士 研究领域及成果: 研究方向主要集中在心血管病和肾脏病的发病机理以及相关的心，肾，血管细 胞的信号传导机理和分子细胞药理学的的研究。已在本领域的国际权威学术刊物 上，如Kidney International, Circulation Research, Hypertension, ATVB, American Journal of Physiology，Antioxidant and Redox Signaling等 发了24篇学术论文， 总影响因子超过100， 并在国际学术会议上发表论文摘要31篇。 2007年在德国 召开的世界高同型半胱氨酸血症大会上获得青年科学家奖(Young Scientist Scholarship)(只有5人获得此项奖励)。 近5年发表的SCI论文 1. Yi F, Li PL. Mechanism of homocysteine-induced glomerular injury and sclerosis Am J Nephrol, 28: 254-264, 2008 2. Li N, Chen L, Yi F, Xia M, Li PL.Salt-sensitive hypertension induced by decoy of transcription factor hypoxia-inducible factor-1alpha in the renal medulla. Circulation Research. 102:1101-8, 2008 3. Zhang F, Jin S, Yi F, Xia M, Dewey WL, Li PL.Local production of O2- by NAD(P)H oxidase in the sarcoplasmic reticulum of coronary arterial myocytes: cADPR-mediated Ca2+ regulation. Cell Signal. 20:637-44 2008 4. Jin S, Zhang Y, Yi F, Li PL. Critical role of lipid raft redox signaling platforms in endostatin-induced coronary endothelial dysfunction. Arterioscler Thromb Vasc Biol. 28:485-90, 2008 2+5. Yi F, Zhang AY, Li N, Zhang F, Mia M, and Li PL. Role of cyclic ADP-ribose-Ca signaling in mediating renin production and release in As4.1 cells. Cell Physiol Biochem 19:293-302, 2007 6. Yi F*, Zhang AY*(co-first author), Jin S, Xia M, Chen QZ, Gulbins E, Li PL. Lipid raft redox signaling platforms in endothelial dysfunction in coronary arteries: role of acid sphingomyelinase, Antioxid Redox Sign 9:817-828, 2007 7. Yi F, Santos E, Xia M, Chen QZ, Li PL and Li N. Podocyte injury and glomerulosclerosis in Hyperhomocysteinemic Rats. Am J Nephrol 27:262-268, 2007 8. Yi F, Chen QZ, Jin S, Li PL. Mechanism of Homocysteine-induced Rac1/NADPH Oxidase Activation in Mesangial Cells: Role of Guanine Exchange Factor Vav2. Cell Physiol Biochem 20:909-918,2007 9. Li N, Yi F, Santos E, Donley D, Li PL. Role pf medullary heme oxygenase in the regulation of pressure natriuresis and arterial blood pressure. Hypertension 49:148-54, 2007. (This article was honored by an editorial commentary “Control of renal Na+ excretion by heme oxygenase” Hypertension 49: 23-24, 2007) 10. Li N, Yi F, Sundy CM, Chen L, Hilliker ML, Donley DK, Muldoon DB, Li PL. Contribution of prolyl hydroxylase to the control of renal function and arterial blood pressure. Am J Physiol Renal Physiol. 292:F207-216, 2007 11. Zhang G, Zhang F, Muh RW, Yi F, Chalupsky K, Cai H, Li PL. Autocrine/paracrine pattern of superoxide production through NAD(P)H oxidase in coronary arterial. Am J Physiol Heart Circ Physio 292: H483-495, 2007 12. Jin S, Yi F, Li PL. Contribution of lysosome-like vesicles in the formation of lipid raft redox signaling platform. Antioxid Redox Sign 9:1417-1426, 2007. 13. Li PL, Zhang AY, Yi F. Lipid raft redox signaling platforms and endothelial dysfunction induced by activation of death factors. Antioxid Redox Sign 9:1457-1470, 2007. 14. Li PL, Yi F, Li N. Hyperhomocysteinemia-Associations with renal transsulfuration and redox signaling in rats. Clin Chem Lab Med 2007 Nov 8; [Epub ahead of print] 15. Yi F, Zhang AY, Li N, Muh RW. Fillet M, Renert AF, Li PL. Inhibition of ceramide– Redox signaling pathway blocks glomerular injury in hyperhomocysteinemic Rats, Kidney Int. 70:88-96, 2006 16. Zhang AY, Yi F, Zhang G, Gulbins E, Li PL. Lipid rafts clusering and redox signaling platform formation in coronary arterial endothelial cells. Hypertension 47:74-80, 2006. (This article was honored by an editorial commentary “Lipid rafts take center stage in endothelial cell redox signaling by death receptors” Hypertension 47:16-18, 2006). 17. Yi XU, Li VX, Zhang F, Yi F, Matson DR, Siebenaler JF, Jiang MT, Zou AP, Li PL. Biochemical and functional characteristics of an NAD(P)H oxidase in the sarcoplasmic reticulum of coronary vascular smooth muscle. Am J Physiol-Heart Circ Physiol. 290: H1136-1144, 2006. 18. Zhang G, Teggatz EG, Zhang AY, Yi F, Koeberl MJ, Chen L, Li PL. Cyclic ADP- ribose-mediated cyclic Ca2+ signaling in mediating endothelial nitric oxide production in bovine coronary arteries. Am J Physiol-Heart Circ Physiol.290: H1172- 1181, 2006. 19. Shen B, Chen M, Cheng Y, Du L, Edwards DJ, George NP, Huang Y, Oh T, Sanchez C, Tang G, Wendt-Pienkowski E, Yi F. Prerequisites for combinatorial biosynthesis: evolution of hybrid NRPS/PKS gene clusters. Ernst Schering Res Found Workshop. 51:107-126, 2005. 20. Teggatz EG, Zhang G, Zhang AY, Yi F, Li PL. cyclic ADP-Ribose-mediated Ca2+ signaling and Ca2+-induced Ca2+ release in renal arterial smooth muscle cells. Microvasc Res. 70:65-75, 2005. 21. Yi F, Zhang AY, Janscha JL, Li PL, Zou AP. Homocysteine activates NADH/NADPH oxidase through ceramide-stimulated Rac GTPase activity in rat mesangial cells. Kidney Int 66:1977-87, 2004. 22. Zhang AY, Yi F, Teggatz E, Zou AP, Li PL. Reactive oxygen species enhances cyclic ADP-Ribose production and intracellular calcium mobilization in small bovine coronary arterial smooth muscle. Microvasc Res. 67:159-167, 2004. 邀请 st1. Department of Medicine/Cardiology, University of Chicago, July 1，2005 “Role of Rac-GTPase-redox signaling pathway in hyperhomocysteinemic glomerular injury in rats exposed to a folate-free diet.” th2. Department of Nephrology, Virginia Commonwealth University, March 28, 2007 “ Redox Signaling in hyperomocysteinemia-induced renal dysfunction” 3. World Congress on Hyperhomocysteinemia-6th Conference on Homocysteine thMetabolism, Germany, June 8, 2007 “Lipid Raft Redox Signaling Platforms in Homocysteine-Induced Glomerular Endothelial Dysfunction”. 2009年拟招收博士研究生1-2名。培养的博士生可从事高校或研究单位的教学与 科学研究，或从事新药研究与开发。提供机会并鼓励学生到国外进修和学习。 联系方式、联系地址、电子邮箱 通讯地址:250012 济南市文化西路44号山东大学医学院药理学研究所 E-mail Address: yifanlucky@gmail.com