Understanding NICE guidance Erlotinib for maintenance treatment 理解NICE指南厄洛替尼维持治疗
Issue date: June 2011
Understanding NICE guidance
Information for people who use NHS services
Erlotinib for maintenance
treatment of non-small-cell lung
cancer
This leaflet is about when erlotinib should be used as maintenance NICE ‘technology
appraisal guidance’ treatment for people with non-small-cell lung cancer in the NHS in advises on when England and Wales. It explains guidance (advice) from NICE (the and how drugs and
National Institute for Health and Clinical Excellence). It is written for other treatments
should be used in people with non-small-cell lung cancer but it may also be useful for their the NHS. families or carers or for anyone with an interest in the condition.
It does not describe non-small-cell lung cancer or the treatments in
detail – your specialist should discuss these with you. You can get more
information from the organisations listed on page 4.
Information about NICE technology appraisal guidance 227 1
There are several What has NICE said?
possible NICE does not recommend erlotinib as maintenance treatment after treatments for non-
chemotherapy that contains platinum for people with locally small-cell lung
cancer. Your advanced or metastatic non-small-cell lung cancer. Maintenance
healthcare team treatment is sometimes used by people whose cancer did not
should talk to you worsen immediately after having chemotherapy (which is also about the
known as stable disease). treatment options
available.
Why has NICE said this?
NICE looks at how well treatments work, and also at how well they
work in relation to how much they cost the NHS. NICE applies
special considerations to treatments that can extend the lives of
people who are nearing the end of their life if they meet certain
criteria. It was not certain whether erlotinib provides enough benefit
to patients to justify its high cost and it did not qualify for special
consideration, so NICE did not recommend it.
Non-small-cell lung cancer
Cancer affecting the lungs is grouped into two main types depending on
how it looks under the microscope: small-cell lung cancer and non-
small-cell lung cancer. Symptoms of non-small-cell lung cancer include
persistent coughing, coughing up blood, shortness of breath, chest pain,
tiredness and weight loss. Cancer that is locally advanced or metastatic
has spread to the surrounding tissues or other parts of the body.
Erlotinib
Erlotinib is an anticancer drug. It works by attaching itself to an enzyme
involved in cancer cell growth and stops the cancer from growing.
Information about NICE technology appraisal guidance 227 2
What does this mean for me?
Erlotinib should not normally be prescribed on the NHS for maintenance
treatment of non-small-cell lung cancer. Your doctor should talk to you about other treatment options available to you.
NICE will decide whether to review this guidance in April 2013.
If you are already taking maintenance treatment with erlotinib for non-
small-cell lung cancer, you should be able to continue taking it until you
and your specialist decide it is the right time to stop.
Information about NICE technology appraisal guidance 227 3
More information
The organisations below can provide more information and support for people with non-small-cell lung cancer. NICE is not responsible for the quality or accuracy of any information or advice provided by these organisations.
, British Lung Foundation, 0845 850 5020
www.lunguk.org
, CancerHelp UK – the patient information website of Cancer
Research UK, 0808 800 4040
www.cancerhelp.org.uk
, Macmillan Cancer Support, 0808 808 0000
www.macmillan.org.uk
, The Roy Castle Lung Cancer Foundation, 0800 358 7200
www.roycastle.org
NHS Choices (www.nhs.uk) may be a good place to find out more. Your local patient advice and liaison service (usually known as ‘PALS’) may
be able to give you more information and support. If you live in Wales you should speak to NHS Direct Wales for information on who to contact.
Information about NICE technology appraisal guidance 227 4
About NICE
NICE produces guidance (advice) for the NHS about preventing,
diagnosing and treating medical conditions. The guidance is written by independent experts, including healthcare professionals and people representing patients and carers. They consider the evidence
on the disease and treatments, the views of patients and carers and the experiences of doctors, nurses and other healthcare
professionals, and consider the costs involved. Staff working in the NHS are expected to follow this guidance.
To find out more about NICE, its work and how it reaches decisions, see www.nice.org.uk/aboutguidance
This leaflet and other versions of the guidance aimed at healthcare
professionals are available at www.nice.org.uk/guidance/TA227
You can order printed copies of this leaflet from NICE publications
(phone 0845 003 7783 or email publications@nice.org.uk and quote
reference N2598). The NICE website has a screen reader service called Browsealoud, which allows you to listen to our guidance. Click on the Browsealoud logo on the NICE website to use this service.
We encourage NHS and voluntary organisations to use text from this leaflet in their own information about non-small-cell lung cancer.
Information about NICE technology appraisal guidance 227 5
National Institute for Health and Clinical Excellence
MidCity Place, 71 High Holborn, London, WC1V 6NA; www.nice.org.uk
ISBN 978-1-84936-637-3
N2598 POD 1P Jun 11
? National Institute for Health and Clinical Excellence, 2011. All rights reserved. This material may be freely reproduced for educational and not-for-profit purposes. No reproduction by or for commercial organisations, or for commercial purposes, is allowed without the express written permission of NICE.
Information about NICE technology appraisal guidance 227 6