壳聚糖和尿囊素预防外科术后腹腔粘连效果的观察

壳聚糖和尿囊素预防外科术后腹腔粘连效果的观察 作者：沈新，李孟彬，王为忠，施海 【关键词】 粘连；壳聚糖；尿囊素；兔 【Abstract】AIM: To investigate the preventive effect of chitosan and allantoin against postsurgical abdominal adhesions and to study the synergetic effects of these two drugs and discuss the mechanism. METHODS: Ninetysix rabbits were chosen to establish intestinal adhesion models, which were randomly and evenly divided into control group (group A)，chitosan treatment group (group B), allantoin treatment group (group C) and chitosan allantoin treatment group (group D). Right after the operation, the situations of rabbits were observed. Then the rabbits were dissected to evaluate the degree of adhesions 1 and 2 weeks after the operation. Study the pathological changes under microscope. RESULTS: The models of adhesions were reliable. The adhesion degrees of group B, C and D were all significantly decreased compared with that of group A (P