H3N2和H1N1甲型流感病毒感染对猪_i_CDK__i_9基因表达的影响

! !" " ! ! "# # $#"% $ "# % !"#$%&'(() ! &'()* " &'()*+,'-.')/0123/4567*892)38/ : ! .+/;<=8;>?; " @',;!" .';"# A=/;$#"% +,-*./ # $#"%B#CB$$ ! "D # #! +,-*01 # 0// E #$$ 111;=*F8;*2/ $ F=G3 $ ?2/+8, $ H";"%C#;<;$#"%#C$$;"D#!;#$#;0/G, 7%8$ 9 7"8" w—˜™š›™œ02 !"#C v_ž?@A ! & 234# ' ! $#"$B"$B"" ! & 5678 ' ! 9:&'()5678 ! %"#D$""L " ! & ABCD ' ! aõö ! "CJHK "( d ( A3÷-M ( NOgQ ( RSTU³qI¯)k“”)]^ ) >BG+8, # 1'+8*8 1 JH#$#$ ! "H%;='G ! & _`AB ' ! 7âø ! "CH$K "( d ( ùÉúLM ( ûü ( gQhij ( RSTU³qI–) % “”) % hW`ý~½¾hW)]^ ) >BG+8, # X0+* M ?2,8 ! /38* M 0(+;') M ;=* $?@ ! A ! B ! :CD ! EFF ! GHI ! 9JJ ! K ! L ! KMN ! ÉÀlÊ(on) VWM)p I–“”khW`ý]^X ( ùÉ Eþ D"$"## " ! B ! C " ! + 8€ , ]^ O%.$ Z O"." +…¤ÝI–ÝÿŠ!Œ"a #JKC 5f{U€—˜ ( #ǤÝqI ²Qk #JKC 5f€æʎ )+ ž , Úë» a`< €!Œ¥¦†Šª ( c À.$rš£ _`c oxZtš£“”· ù”)ž ( „ä O%.$ Z O"." +…¤ÝI–ë»Ýÿ D? ó ( !Œ"a _YdC € Gc.4 Z…†{U€Z” ( ªN£ qï3%*&~ _YdC LŽL"€ší )+ Òê , À.$rš£ _`c „ä{è ( O%.$ Z O"." +…¤ÝI–Ýÿ !Œ D? ó ( "a·ùÞ #JKC 5f Gc.4 €æŠ{U£³Ê¥ #;!$ Z #;%H ( kŠª ! ";# " æ­ïð'û ! ! " #;#L ") tš£“”·ù”)„äÒêïÇ ( !Œ2b O%.$ Z O"." ¤ÝI–Ýÿó ( "a·ùÞ _YdC …†€æ Š{U‡ˆ³Ê¥ %";! Z %J;D ( 4úU·ù ! H";! " ïð'û ! ! " #;#L ") £qï3%&~qË ( O%.$ Z O"." + …¤ÝI–Ýÿ!Œó ( "aL"'ˆƒèï ( _YdC LŽL"(N³5òÔ£L);ŸZ"*Þ ( ˆ"+&µ4] ( %;L"8¢&µZ, )+ Ò- , 2b¤ÝI–Ýÿó ( !Œ"a·ùÞ #JKC {U£'û ( ù; c.4 E ', % áÿ ”‡ˆ'û€¯f>Ð ) ! DEF " ! ¤ÝI– * #JKC 5f * À.$rš£ _`c * “”·ù”) ! GHIJK " ! NO " ! 4 ! LPQK " ! "HD"BC%JD ! $#"% " "#B##"!B#L !""#$%&"<%=$)-'<"="(-".6#->)?/(*60(-"#$%(&-&- #@ , *#00(&-&" , &*$(-#!12C 1 #-# PVY2* M B : (* ( <7.T+* ( &V4.I 2`* M B-28 ( d4.IZ0+*BX0+* ( ^4.I&8* M B*+ ( O74P8*B,8* ( ZO4.IT+* M ( ZO4.IY2B,8 ! D&9&-5/2"-;$5-6$5 3 $ ( ?+5$%$ '3 ( >,,4*$%$ '3 L<+$+* ( $5,-6+/9 ( #$%%& ' &$ ( ?&6&5+*-5 3 @&0+/+*& ( G$562M&96)LA7*+8&59+6 3 ( B-* ' %+* ' ( .2--*N+D"$"## ( #2+*- " !"#$%&'$ #+ A[ \ 2=/892 , Q0833/(? : +8G2?/'8*923/8 M +/2/028*-,(2*=2'-8*-,(2*X+498)(3O%.$+*? O"."8*-2=/8'*'*/022b E )2338'*'-#JKC ( +*?(*='92)/02+33'=8+/8'*[2/122* E +/0' M 2*2383'-8*-,(2*X+ 498)(3+*?#JKC; + R2/0'? , ] cQB`_c+*?32G8B ] (+*/8/+/8928GG(*'083/'=02G8=+,+33+ : 12)2+ EE ,82?/' ?2/2=//02Gc.4+*? E )'/28*2b E )2338'*,292,3'-_YdC8*318*2,(* M /833(2D?+-/2)8*-2=/8'*'-O%.$ +*?O"."98)(3;P'=+/8'*3'-_YdC E '38/892=2,,312)2'[32)92?18/02,2=/)'*G8=)'3=' E 2;`8 M ,2/38*'=(,+B /2?18/0 a`<12)2(32?+3[,+*F='*/)',; + c23(,/ , ] cQB`_c?2/2=/8'*30'12?/0+/#JKCGc.42b E )23B 38'*,292,312)2#;!$+*?#;%H+-/2)[28* M 8*-2=/2?18/08*-,(2*X+498)(3O%.$+*?O"." ( )23 E 2=/892, : ( 108=012)238 M *8-8=+*/, : )2?(=2? ! ! " #;#L " ='G E +)2?18/0[,+*F='*/)', ! ";# " ;<2G8B ] (+*/8/+/8928GG(B *'083/'=02G83/) : +33+ : 30'12?/0+//022b E )2338'*'-_YdC E )'/28*8* E 8 M ,2//833(238*-2=/2?18/0O%.$ +*?O"."?2=)2+32?/'%";!+*?%J;D-)'GH";! ! ! " #;#L " ;>,2=/)'*G8=)'3=' E 2'[32)9+/8'*30'12?/0+/ ,(* M =2,,['(*?+)823[2=+G29+ M (2+-/2)8*-,(2*X+498)(3O%.$+*?O"."8*-2=/8'* ( _YdCB E '38/892=2,,3 3=+//2)2?8*/02/2)G8*+,[)'*=08',2+*?+,92',(3 ( +*?/02*(=,2(33/+8*2??+)F ( 108,2/02'92)+,,=',')'- =2,,3[2=+G230+,,'1; + _'*=,(38'* , Q022b E )2338'*'- E ')=8*2#JKC?2=)2+32?+-/2)8*-,(2*X+498)(38*B -2=/8'* ( 108=0G8 M 0/[2+33'=8+/2?18/0/02?2=)2+32?'-c.4 E ', %E 0'3 E 0') : ,+/8'*,292,+-/2)8*-,(2*X+4 98)(38*-2=/8'*; () * +,%-# # 8*-,(2*X+98)(3 * #JKC M 2*2 * ] cQB`_c * 8GG(*'083/'=02G83/) : !! ¤ÜŽÝ-;¤ÝI–Í΀лMtÅJ. ƒñXÿI ( ÍXÿŽD ( X/ƒãÿ ( Uþ¤ÜŽ 0Wn¤ÜŽqh ) ¤ÝI–ìòú1I–( ( ² ßqh5f?· ) Î}͒2áZ34¿ÿ€ƒ „ ( ùñ¤ÝI–³¥ "H ´ O 4… ! O"KO"H " Z C ´ . 4… ! ."K.C ") +…¤ÝI–y€ O"." ! É5­¤Ý "% O$.$ ! 46¤Ý "% O%.$ ! à7¤ Ý " Z OL." I–849Ü¤Ü ( ˆiу„w㠀ÝÿZš› ) $##C $ ( O"." +…¤ÝI–€¤ ÜéʫŚh)Ì-’±n€:; & "B$ ' ) L"¾#}ӎ…†à C ! _YdC " ìòL" ¾#}ӎà:< ! _ : =?2 E 2*?2*/F8*+323 ( _Yd3 " hf ( ; I)+*+ H & % ' ò "CC! $qˀд Ù =?=$ €?¿ÿ $ Ô¿ÿ…†à ( N÷·ùy= >øN ) <0')2 H & ! ' N O2P+ L"yq˒ _YdC €! $ »øN'Z ( ­¯Wqˀ _YdC ³q‘£ n "%F( ( ñ $ » _YdC ³q}¦?‰¥ _YdC !$ ! ³ q‘£¥ !$F( " Z _YdC LL ! ³q‘£¥ LLF( ") _YdC æÊ_@NhA5wyq¾&?SA  ( ¢ L"³” % Y.4 7¹H ) _YdC $ _ : =Q$ ùÚuÛ ýL"€³” & L ' ) N Y.4 ¹Q½¸* ( _YdC ¶B kòÿµ‘ ( ¨í¹QC€'Ó ( ˆQ$D Y.4 € |£ ( ¢ê[¼ _YdC )B _ : =d ( ¶—˜L"¾# €E¹ ( iÑ Y.4 &q€FG ) „. ( _YdC $ _ : = d ùÚk Y.4 7¹…†æHA  ( {è _YdC $ _ : =d Ný™5f·ò8ŽRq¾&?SA   & H ' ) _YdC k ! »L"¾#…† _ : = ! Q" % Q$+ % Q$[ Z d " Òq'húŽ¿ÂIfq [ ! B`Q>6[ " ¹qW & D ' ( t¹qW_5ñ c.4 E ', % €J5£B ÒÈKZüŽ¿ÂIfqáÿ” ( _¿ÂabI L ( %¤ÝI–Ýÿó ( c.4 E ', % €áÿ”‡ˆ¶ 'û ) <+,2)*' H & J ' qË ( 3Q _YdC 1ŽùÚ@e iÐI–€¹QZ¿Â ( VMNƒ—˜ Q L"à 1 ) ¥’]^¤ÝI–ÝÿŠ!Œ"a #JKC { U€—˜ ( ‚Œ _YdC k¤ÝI–Ýÿ€æʎ ( ÏÃÄNhóÃOŒ #JKC 5f & C ' €5Úã ( _5 À.$rš£ _`c ! ] cQB`_c " oxZtš£“” ·”ž ( „ä’ O%.$ Z O"." +…¤ÝI–Ýÿ ó!Œ"a·ùy #JKC {U£€Z” ) " ! p\kž ";" ! Ÿ ! ˆ Q)8X', x& V*98/)' M 2* «‰ ( )`8G2<=)8 E / QR cQ )2+ M 2*/d8/ Z ] cQB`_c Ãvw b 1- O QR x& Q+d+c+ «‰ ( 4*/8B_YdC B¢x& ÀÁgP«‰ ( “”·”QR ?56 ! Î} ._aV ㌠#JKC 5f˜¬ ! I2*a+*F # .R 1 ##""HH#!! "(   a2+='*Y238 M *2)D;# Û¡w= " ŠIúŽÍW ( Õ#^©#Ç¥ "!J[ E ) ÍW˜ ¬ "` # LjBQI_QI_QQ44_II__Q_Q4_Q4B%j ( $` # LjB_4_4QQ4I_4I__QQ_4QIQ__B%j ) Ú Œ ! I-/6+* ! I2*a+*F # Yk!L$LHC;" " A¥$rš£ _`c €Þy5f ( ÍW˜¬ %` # LjB_44II4_ _Q_Q4_I__44_4_B%j ( !` # LjB4II4QII4I_ _I__I4Q_B%j ) ÍW3Á6_hWox@ˆ 16 ! "# # aõö ( H # O%.$ Z O"." +…¤ÝI–ÝÿŠŒ #JKC 5f{U€—˜ «‰qh ! ]”Z¥ O` P_ ") ";%;% ! 7 #JKC 8 ! I-/6+* 4 ] cQB`_c ! ö𢠽¥ $L # P # =Y.4$ # P ( ã_ÍW " # P ( *_ÍW " # P ( b E )2338'*,292,'-#JKCGc.48*,(* M 3'- E 8 M ,2/38*-2=/2?18/0O%.$+*?O"."8*-,(2*X+ 498)(3?2/2=/2?[ :] cQB`_c Y8--2)2*/,'12)=+32,2//2)38*?8=+/238 M *8-8=+*/ ?8--2)2*=2;68 M ;$833+G2 2 $ ! Ýÿ O%.$ Z O"." +…¤ÝI–ó!Œ"a ·ùy _YdC €“”·ù”)³jÒê 68 M ;$ ! VGG(*'083/'=02G8=+,+*+, : 383'-_YdC8*,(* M 3'- E 8 M ,2/D?+-/2)8*-2=/8'*18/08*-,(2*X+ 498)(3O%.$+*?O"." $;% ! O%.$ 9 O"." ™œ¨ 2©“ _YdC ¬5 ­®?Ž¯ 2 % ùڔ- ( ¦§Šª!Œ _YdC LŽL "9ܳ5ò"a·ùy ( ÍyÔ£L);Ÿ$K üh`øã­L"Z"*$KÞ­L"€L"+& µ4] ( L"‘&µd, ( "*oÞL"+ZL"‘ &µ¡4, ) ü O%.$ Z O"." +…¤ÝI–Ý ÿ!Œó ( "aL"'ˆƒèï ( _YdC LŽL"( 26 ÉÀlÊ(on))Ë ! &'()* " ! !" " N³5òÔ£L);ŸZ"*Þ ( ˆ"+&µ4] ( %;L"8¢&µZ, ) 2 % ! O"." Z O%.$ +…¤ÝI–Ýÿó D? !Œ"a _YdC LŽL"€“”·ù”)„ä ! g!## " 4; úUŒ"a·ù * a;O"." +…¤ÝI–Ýÿ€!Œ"a·ù * _;O%.$ +…¤ÝI–Ýÿ€!Œ"a·ù 68 M ;% ! VGG(*'083/'=02G8=+,'[32)9+/8'*'-_YdC E '38/892=2,,38*,(* M /833(2'- E 8 M ,2/3D? +-/2)8*-2=/8'*'-O%.$+*?O"."8*-,(2*X+498)(3 ! g!## " 4;P(* M /833(2'-*')G+, E 8 M ,2/3 * a;P(* M /833(2'- E 8 M ,2/3D?+-/2)8*-2=/8'*18/08*-,(2*X+498)(3O"." * _;P(* M /833(2'- E 8 M ,2/3D?+-/2)8*-2=/8'*18/08*-,(2*X+498)(3O%.$ % ! ‚ ! - O> ÿµó ( N£qï3%*&~qË ( +… O%.$ Z O"." I–ÝÿŒ¢ó ( ¡fhКw㠀"a·ùI¶»p ) +… O%.$ I–Ýÿ!Œ ó ( òhL’Ÿqh:’ ( ’ŸÞ­L"ƒ„wã ©h ( fh"aoèï©® * ü+… O%.$ Z O"." I–¡fh$Küh`øã­L"ƒ„wã»p½ ¹ ) ´ù;òI–N"Ô£L);Ÿ$Küh `øã­L"Þ©G ( füfhL"»p ) mù † ( ÃÄyÈq€VWY…hóÝÿ’¤ÝI– ( ù  òó™ÃĀ]^ ) ¤ÝI–Ýÿó ( c.4 E ', % áÿ”‡ˆïð' û & "" ' ) НR ( I–_5…†¢r%'Óáÿ” € c.4 E ', % ( FG²¢€BI–½¾ & "$ ' * sН R ( I–BqZ 4` 45ùÚIú'Óáÿ”€ c.4 E ', % & "% ' ) %; ( c.4 E ', % €'Ó}Óò¤Ý I–€–¸ ( ø–tÝÿó c.4 E ', % ƒ¶qh' Ó & "! ' ) ü _YdC ùÚáÿ” c.4 E ', % ( ¥’‚ _YdC k¤ÝI–Ýÿ€æʎ ( ÏÃÄTÝÿ¤ ÝI–€!Œ"a·ùyÌå c.4 ªö¿Âab =Y.4 ( 4$rÀ.š£ _`c „ä{è ( ¤ÝI– ÝÿŒ¢ó ( "a·ù #JKC 5f Gc.4 ‡ˆè ï'û ) I¶û#4tš£“”·ù”)žuš ( _YdC …†4úU·ù…†{U‡ˆ'û ) mA Bvä ( _YdC {U£'ûù;¤ÝI–Ýÿó c.4 E ', % áÿ”‡ˆ'û€¯f ) mÌ ( Z0+* M H & "L ' ]^{è ( ¤ÝI–Ýÿ O2B P+ L " ó ( _YdC Z ¤ Ý I – c.4 B q  ! 9c.` " € a` $ 45øNճŚí * “”ÅÁw „äé{è ( _YdC ºk 9c.` € a` $ Z .` 4 5qhæHA  ) vä+…¤ÝI–Ýÿó ( 9c.` k _YdC æHA  ( 3Q’í£øN€ _YdC …† €1Ž ( TüiÑ c.4 E ', % áÿ”‡ˆ'û ) ¤ ÝI–Ýÿó #JKC {U'û€?¢²Q8Öx ƒ“x ( nSÛЇ]^yÀ ) ! }~LM " & " ' ! R8*')`Y;@+==8*23+ M +8*3/32+3'*+,+*? E +*?2G8=8*-,(2*X+ +*?/028G E ,8=+/8'*3'-=0+* M 238*3([3/)+/23-')98)(3 E )'?(=B /8'* & & ' ;_,8*V*-2=/Y83 ( $#"# ( L# ! ! "# LH#BLHL; & $ ' ! <12?830d4;$##C E +*?2G8=8*-,(2*X+4 ! O"." "# Y8+ M *'383 ( G+*+ M 2G2*/ ( +*? E )292*/8'*B,233'*3,2+)*2? & & ' ;_())V*-2=/ Y83c2 E ( $#"" ( "% ! $ "# "HCB"D!; & % ' ! I)+*+U ( Y2P(=+4 ( <+* M . ( 2/+,;`VQ4Pc> ( +*(=,2+)_Y_$B )2,+/2? E )'/28*F8*+32/0+/ E 0'3 E 0') : ,+/23/02)2/8*'[,+3/'G+ E )'/28*+*8+65$ & & ' ;`)'=22?8* M 3'-/02.+/8'*+,4=+?2G : '- <=82*=23'-/027*8/2?6[ & & ' ;I2*235Y292,' E G2*/ ( "CCJ ( "$ ! L "# DLLBDH$; & J ' ! <+,2)*'Y ( O+30+GRI ( R+)30+,,c ( 2/+,;Y8)2=/8*08[8/8'*'- #JKC[,'=F3OV@B")2 E ,8=+/8'*18/0'(/ E )292*/8* M QB=2,,+=/8B 9+/8'*8* E )8G+) : 0(G+* E 2)8 E 02)+,[,''?, : G E 0'= : /23 & & ' ; I2*2 ( $##D ( !#L ! " $ $ "# HLBDJ; & C ' ! 74á ( z ! { ( a|} ( H ; Œ #JKC 5f€ÃO~5{UŠ <7@>_3 L"¾#€—˜ & & ' ; ÉÀlÊ(on))Ë # &' ()* ( $#"# ( %J ! J "# %%B%C; Z0+* M T& ( <'* M O ( P8TP ( 2/+,;_,'*8* M +*?2--2=/'-'92)B2bB E )2338'*'-= : =,8*B?2 E 2*?2*/F8*+32C'*=2,,= : =,2'-<7@>_ =2,,3 & & ' ;&'()*+,'-.')/0123/4567*892)38/ : # .+/()+,<=8B 2*=2>?8/8'* ( $#"# ( %J ! J "# %%B%C; ! 8*_08*232 " & "# ' ! ~á ( EIˆ ; €-,y’Ÿ1Žc€“”·ù”)&~ & & ' ; ‚ƒ1tu{M ( $##L ! ! "# "LB"H; k8* M 98B ?2*=2'-/02 E )'?(=/8'*'-98/+G8*a "$ [ : G8=)'') M +*83G38* /028*/23/8*+,=+*+,'-=+) E # 3F 5+*49/-5 F +$ & & ' ;a(,,2/8*'- /02&+ E +*232<'=82/ : '-<=82*/8-8=68302)823 ( "CD# ( %H # !$"B !$!; & "J ' ! P8*TO ( (^&T ( <08+(9+,(+/8'*'-/02='B [+,/)2 ] (8)2G2*/'-[22-=+//,2[+32?'*98/+G8*a "$ ( -',+/2 ( 0'G'= : 3/28*2+*?G2/0 : ,G+,'*8=+=8? & & ' ;a)8/830&'()*+,'- .(/)8/8'* ( $### ( J! # H!LBHL%; & $" ' ! d2**2? : YI ( _+**+9+*4 ( R',,' : 4 ( 2/+,;R2/0 : ,BG+,'* : ,B _'4G(/+32 ! >_L;!;CC;$ " +*?G2/08'*8*23 : */0+32 ! >_$; ";";"% " 8*/02/833(23'-='[+,/B98/+G8*a "$ ?2-8=82*/3022 E & & ' ;a)8/830&'()*+,'-.(/)8/8'* ( "CC# ( H! # D$"BD%$; 46 ÉÀlÊ(on))Ë ! &'()* " ! !" "