GlaxoSmithKline
NMR Chemical Shifts
for Residual Protons in Solvents
Solvent CDCl3 (CD3)2SO D2O CD3OD
Acetic Acid 2.13 1.95 1.16 1.99
Acetone 2.17 2.12 2.22 2.15
Acetonitrile 1.98 2.09 2.05 2.03
Anisyl Alcohol 4.61, 3.79 4.44, 3.74 4.57, 3.81 -
Benzene 7.37 7.40 7.44 7.33
Bromoform 6.85 7.75 insol 7.42
n-Butanol 3.67(t)
0.94(t)
3.41(t)
0.89(t)
3.60(t)
0.89(t)
3.54(t)
0.93(t)
t-Butyl Alcohol 1.28 1.14 1.23 -
Chloroacetic Acid 4.14 4.28 4.25 -
Chloroform 7.27 8.35 insol 7.88
Cyclohexane 1.43 1.42 insol 1.45
1,2-Dibromoethane 3.63 3.84 3.79 3.72
Dichloroacetic Acid 5.98 6.68 6.21 -
1,2-Dichloroethane 3.73 3.93 3.92 3.78
Dichloromethane 5.30 5.79 Insol 5.48
Diethyleneglycol,
dimethyl ether
3.60(m)
3.38
3.49(m)
3.28
3.63(m)
3.37
-
Diethyl Ether 3.48(q)
1.20(t)
3.42(q)
1.13(t)
3.56(q)
1.17(t)
3.48(q)
1.17(t)
Diisopropyl Ether 1.12(d) 1.04(d) 1.12(d) -
Dimethylacetamide 3.01, 2.94,
2.08
2.99, 2.82,
1.99
3.05, 2.89,
2.08
3.05, 2.91,
2.07
Dimethylformamide 8.01, 2.95,
2.88
7.98, 2.92,
2.76
7.91, 3.00
2.86
7.98, 2.99,
2.85
Dimethyl Sulphoxide 2.62 2.52 2.70 2.65
Dioxan 3.70 3.61 3.75 3.65
Ethanediol 3.76 3.42 3.66 -
Ethanol 3.72(q)
1.24(t)
3.49(q)
1.09(t)
3.64(q)
1.16(t)
3.60(q)
1.17(t)
Ethyl Acetate 4.12(q)
2.04,
1.25(t)
4.08(q)
2.02,
1.21(t)
4.14(q)
2.08,
1.23(t)
4.09(q)
2.01,
1.23(t)
Ethyl Formate 8.04
4.22(q)
1.29(t)
8.23
4.17(q)
1.24(t)
8.16
4.28(q)
1.29(t)
-
-
-
Formic Acid 8.02 8.18 8.22 -
Furfuraldehyde 9.68
7.71(m)
7.25(m)
6.60(m)
9.69
8.14(m)
7.59(m)
6.82(m)
9.52
7.94(m)
7.59(m)
6.78(m)
-
-
-
-
Isobutyl Methyl Ketone 2.12
0.92(d)
2.08
0.88(d)
2.19
0.88(d)
2.11
0.91(d)
Isopropyl Acetate 2.02
1.22(d)
2.00
1.21(d)
insol 1.99
1.22(d)
Isopropyl Alcohol 4.03(m)
1.20(d)
1.06(d) 1.18(d) 3.92(m)
1.14(d)
Methanol 3.48 3.20 3.35 3.35
Methyl Acetate 3.67, 2.05 3.61, 1.92 3.68, 2.09 -
Methyl Iodide 2.16 2.21 insol 2.15
Morpholine 3.69(m)
2.85(m)
3.52(m)
2.68(m)
3.70(m)
2.79(m)
3.64(m)
2.79(m)
Nitromethane 4.32 4.44 4.41 -
Petroleum Ether(60-80) 1.28
0.90(t)
1.28
0.89(t)
insol 1.30
0.88
Potassium Acetate insol 1.60 1.91 -
Propane-1,2-diol 1.17(d) 1.04(d) 1.13(d) -
Propanol 3.60(t)
1.60(m)
0.93(t)
1.45(m)
0.87(t)
3.61(t)
1.57(m)
0.89(t)
3.49(t)
1.54(m)
0.92(m)
Propionic Acid 2.42(q)
1.18(t)
2.26(q)
1.03(t)
2.47(q)
1.10(t)
-
-
Pyridine 8.60(m)
7.69(m)
7.28(m)
8.61(m)
7.83(m)
7.40(m)
8.50(m)
7.90(m)
7.46(m)
8.53(m)
7.84(m)
7.43(m)
Succinimide 2.75 2.63 2.78 -
1,1,2,2-Tetrachloroethane
Tetrahydrofuran
5.96
3.74(m)
1.85(m)
6.92
3.63(m)
1.78(m)
Insol
3.75(m)
1.88(m)
-
3.72(m)
1.87(m)
Toluene 7.19, 2.34 7.22, 2.32 insol 7.14, 2.30
1,1,1-Trichloroethane 2.72 2.80 insol -
Triethylamine 2.56(q)
1.03(t)
2.47(q)
0.99(t)
2.59(q)
1.02(t)
2.56(q)
1.06(t)
Trimethyl Borate 3.48 3.46 reacts -
Trimethyl Phosphate 3.80(d) 3.72(d) 3.82(d) -
Trimethylamine.HCl 3.23q, 3.34t
Pyridine.HCl 8.92m, 8.19m
8.69m