牙齿缺失可成为成年小鼠海马齿状回神经元新生的抑制因素

牙齿缺失可成为成年小鼠海马齿状回神经元新生的抑制因素 SICENCE新闻发布 作者:苏少晨 稿号:N20120323003 牙齿缺失成年小鼠海马齿状回神经元的新生收到抑制 牙齿缺失可成为成年小鼠海马齿状回神经元新生的抑制因素 已有研究表明，大量牙齿缺失对小鼠学习记忆能力存在影响，可增加阿尔茨海默病的发病危险。来自 中国兰州大学第二医院苏少晨所在团队在假设牙齿缺失对海马齿状回神经元会有一定影响的前提下 设计了此实验。结果发现，牙齿缺失小鼠海马齿状回新生神经元的标志物双皮质素和成熟神经元的标 志物神经元核抗原蛋白阳性表达细胞密度及荧光吸收值均降低，说明牙齿缺失可抑制成年小鼠海马齿 状回神经元的新生。文章发表在《中国神经再生研究(英文版)》杂志2014年9月第17期。 免疫荧光染色显示，牙齿缺失小鼠海马齿状回新生神经元标记成熟神经元细胞核的标记物NeuN阳性表达细胞数量减 少 Article: "Tooth loss inhibits neurogenesis in the dentate gyrus of adult mice," by Shaochen Su1, Tao Qi2, Baoli Su3, Huibin Gu3, Jianlin Wang1, Lan Yang1 (1 School of Life Sciences, Lanzhou University; Second Hospital, Lanzhou University, Lanzhou, Gansu Province, China; 2 First Hospital, Lanzhou University, Lanzhou, Gansu Province, China; 3 Changzhou Institute of Mechatronic and Technology, Changzhou, Jiangsu Province, China) Su SC, Qi T, Su BL, Gu HB, Wang JL, Yang L. Tooth loss inhibits neurogenesis in the dentate gyrus of adult mice. Neural Regen Res. 2014;9(17):1606-1609. 欲获更多资讯:Neural Regen Res Tooth loss inhibits neurogenesis in the dentate gyrus of adult mice Tooth loss has been shown to affect learning and memory in mice and increases the risk of Alzheimer’s disease. The dentate gyrus is strongly associated with cognitive function. Shaochen Su and co-workers coming from the Second Hospital of Lanzhou University, China hypothesized that tooth loss affects neurons in the dentate gyrus. Immunofuorescence staining revealed that the density and absorbance of double-cortin- and neuronal nuclear antigen-positive cells were lower in the tooth loss group than in the normal control group. These data, which have been reported in the Neural Regeneration Research (Vol. 9, No. 17, 2014), suggest that tooth loss may inhibit neurogenesis in the dentate gyrus of adult mice. SICENCE新闻发布 作者:苏少晨 稿号:N20120323003 Compared with the normal control group, the number of NeuN-positive cells was lower in the tooth loss group (immunofuorescence staining). Article: "Tooth loss inhibits neurogenesis in the dentate gyrus of adult mice," by Shaochen Su1, Tao Qi2, Baoli Su3, Huibin Gu3, Jianlin Wang1, Lan Yang1 (1 School of Life Sciences, Lanzhou University; Second Hospital, Lanzhou University, Lanzhou, Gansu Province, China; 2 First Hospital, Lanzhou University, Lanzhou, Gansu Province, China; 3 Changzhou Institute of Mechatronic and Technology, Changzhou, Jiangsu Province, China) Su SC, Qi T, Su BL, Gu HB, Wang JL, Yang L. Tooth loss inhibits neurogenesis in the dentate gyrus of adult mice. Neural Regen Res. 2014;9(17):1606-1609.