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硝酸银软膏抗菌作用的研究 R446.5 ???????????h??1]0?G?????? ???b?]???RA?????%??1008-0023(2001)06-0349-02 ?????????D?w?>?%???!?????D?????????Y?2?; ?!???????D???u?????????”?????2???”???????D?? ??/R?’???O???D?8??/R?????W?9?G?T???2?2?D1968 ????Fox[‘]???(?????????b???J????/4?D?”?????D?~ ??????2%???????b???A?T???S?S?G?8????/4???2?? ?????2?????%?x?????????y???????Y?%?D???2?F?? ?[????0.1%???????????u?????????E???y???J?}?2 ???D?(???G?T???D/4?f???A?????????????????Q?? ?????????2???H?????[???2???????????????????z ??/4 1?????(???? 1.1???????????? ?4?b???1??????????????????????/4 ????????:0.1%???????????!???2???/?r???? ?l??/4(????:941229,950506?G?2(96)????????X- 163(2)??) ????????:2%???????????Q?!???????2?????? ?r?????l??/4(????????(87)2622???2????:1994- 1??77) 1.2?”???L?? ??180???2?vII??150???21??30???2?f???? ???????????????????????????H?????2???A???2?? ????/R???????a/R?????????????Y?I???2?1?j???D?+ ???l????????Q???Q/4?????(?????I???????????” ?G?]?]?2?A??????t?????.?1/4 ?D???????u???D?2???????-?5?I/R?1?j?????2 ????????2-4mm?2?????(?5???%?w???*?2???????? ???C/4 1.3?????]?] ?vIl??:?I?????????????”???P??/4 m???????e?????????-????????[4.5]0 1.4MIC??Ag+?????}?? ?????????I???????1???2????60?>???x?;?? ???????????.?6??[21?2???D?????????????????????2 ???}??Yc???e?S/4 ?D??Y-?A???O???????}??0.1%?????????? ??2%????????????????Ag+????/4 2???? 2.1?vII?? ????1?~?????-?????????????????????N?? ??1?vn?????Y?D???(?I?????????????????? ?D???( ?P?? ?+???lSD-Ag?Q P?a ?p?S???”?S???p?S???”?S?? ?D???? ?D???( I?P 3?P 7?P 10?P >0.05 >0.05 >0.05 >0.05 >0.05 65 84 Mt 45 j . ?? ??. ?? 2 6 6 lf ?r 8 6 ?? ?r 72 84 17 44 ~?’ ~b f/R ?i 7 6 ??j 6 ?A???T??????????/4 2.2DI?? ?D30???????~?2?D??5?P?H???-?????????? ???2???}?????S??10,?2?+???l???A2???2???????? ?????A5??/4 2.3MIC ??2MIC???? ???????9?????E?? ???? ?Y?> MIC90 ug/ml MIC???? ?6?????> MICMIC ug/m/F?6?0 ?????? ???x?;?? ??168-31??318-62 ??168-360318-6 ????2?~?????-???2???????(?????????????k ???A??!ff?2?T?z?????????D/4 2.4Ag’?????}?? ??3Ag’I*?????????? 0.1%??????????2%???????b???? Ag+????597ppm ????3?~?????-??0.1%???????????~??Ag”?? ????2%????Olrk????????/4 3i.1??(?-???f346??) ???5??f/R330(X)6???2?2?????e?????f???L???e?????Y?? 346?? ?????S?%???e?S?6???????2?e???u?????A?z?/?*?? ?????????????????S?%?2???????????S?%?????N?S ?????2???%?2???DEDTA???T?f???C?????2???????? ???N???T?????S?%?2????????????/4 ?1?????????S?%???e?S???J?5???????????] ???????/???J???4?J?5?~?}???2?????N???r???T kineticparametersofcaeruloplasminsubstrates.BiochemJ,1972, 129:273-283. [2]Winkles),JonesAF,WinyardP,Blake methodforthekineticmeasurement DR,LunecJ,Anautomated offerroxidaseactivity.Ann ClinBiochem,1988;25:250-254. [3]TakayanagiM,YashiroT,Determinationofhumanserumceruo- 103.8%??106.68%?2???(???J???4?J?]?f???????S plasminbyionchromatographybasedonitsferroxidaseactivity) Chromatogr,1986;374:378-382. ?%???e?S?????r?2??????/4 ?f???}???J?5?????S?%???????S?,???D??:?? ?l???H?????%?1???2???y?D???)/R???a??/R???????l ???2???]?f?4?i?????2???1?]?f?????%?}???????2?[ ?3???????}????/4 (?f???D?????R?”???????~???????A?e???]???-?? ?9?2?D???l?g/4) ???6???b ??YoungSN,CurzonG.Amethodforobtaininglinearreciprocal plotswithcaeruloplasminanditsapplicationinastudyofthe [4]?????/.(???D?e????????/-?8?????????u???z?B.1996,453-454. [5]?????2?G.?E???J?5???????????????O?????J?5?????????S?%?? ?e?S???????O?????B?T???2???????e???y??,1999,10,31(5):263- 264. [6]OzeanErel.Automatedmeasurementofserumferroxidaseactivity. Clin.chem,1998,44:2313-2319. [7]CousinsRj.Absorption,transport,andhepaticmetabolismofcopper andzinc:specialreferencetometallothioneinandceruloplasmin. PhysiolRev,1985;65:238-309. (?8???f349??) ???Y?????l???????????7???2?u?’?????Y???? ???????e??????/4???Y?????S?l???S?7???????I ???2?I???n?????J???????3???2???????D?????l?M ?3?x???/?A?z?????2?J???J???%?D?????????%?0?? ???????r?I???l???!?A???S???)?G[z10 ???8?????[???????????-?????????(?????? ???????k???A?????2?T?z?????????D41?2?????A?z ?/???*???????I???l??/4 ????2,311?2?????-??????????MIC/4???????? ?????b???2???????(Ag+???????4?A???]?A????/4 ???!??2%????}1011-???Q???J???T???S???T?2 ?A??????????????;?????T???????J???T???S?2?? ?E???y???J?}.?[?r??0.1%??????????/4?????D?? R?????????5??/R???????x?????B?2?2?k?/???}?3?? ?N?G???????”???O???D?8???Y?S?T??/4?[???????? ???20.1%?????????????J???T???S???)?2?2?[???P ???I???0?0??1;,1i61 ???8?J???2???????(???????b?????k???A???? ?2?T?z?????????D;0.1%???????????~??Ag*???? ????2%????????????????;0.1%?????????????J ???T???S???)?2?2?[???P???I???0?0????/4???2?F ?????T0.1%???????????u???????????Y?A?????a?? ?J???A???2???A???[???”?????D????/4 ???6???b [1]FoxCL.Silversulfadiazine-anewtopicaltherapyforpseudomo nasinburns[J].ArchSurg,Feb,1968;96:184-188. [2]EdwardET,HeatherAS,AudreyG,etal.Amatched-pair,randomiz edstudyevaluatingtheefficacyandsafetyofacticoatsilver- coateddressingforthetreatmentofburnwounds[J1.JBurnCare Rehabil,1998;19(6):531-537. [3/)?M???2???c???2?,???m?2?G.???Y?I???l??????1116?>?1??[.1l.?~ ?????????Y?%???y??.1995;11(1):49. [4]???l???2???s???2???????2?G.?n???-???????????????”???)?G/91l.?8 ???f?????e?S???????21982;(3):19. [5]???????2???u???2?!?;?(?2?G.?n???-???????????????????”?????? ?[??[Jl.?~???k?????Y?%???y???21992;8(2):97. [6]???????2???????????2?G.?+???l?D???????????~?????D[Jl.?? ??N?????????2,2001;41(1):108-109.