[doc] 大剂量丙种球蛋白辅助治疗小儿AAD 31例疗效观察

[doc] 大剂量丙种球蛋白辅助治疗小儿AAD 31例疗效观察 大剂量丙种球蛋白辅助治疗小儿AAD 31例 疗效观察 4?????? ???9??????HIE???????????T?,???t?????d?? ???????/[??I?2(I?2EP)?M??]????,???a???? ?????A?????? [2] ,???????????/???a??HIE?????( ???2?H???C???c?????????????H?d??????,?????9 ?K?????T?????]??????I?2EP,????????I?2EP????, ????I?2EP???????t?????9???,???????????????/; ?;???????????????????d?????????9?????d?????? ????,???????9???????????8?????K????????,???N Na2K2ATP??????,???;??????????????,???????? ??????,????????,?????????????????V [3] ,?????? ????????,??????????,?????d?a?????????T?????? ??????,?????T??????????????????;?????[???d?? ????,??????????????????,?????0?????????????? ?0?????????????????9?H???C??????I?2EP?????? ??????,?????/?4????????45min,???????????9?? ?????????/?????????????H FDP?c?????????????8??,?0???I?????8?t???? ???????d?;???4????????????,???????910??15min, ???????????????????????HFDP?c???????????8?? ?????t?????????????I????,???????????8?t???9?? ???????????????1????????,?????????8?I??,???? ????????,??????????????????????????????????, ???;?????T???d???4?HFDP?????0?????????????? ??,????????????????Ca 2+ ????,???????????d???? ???/???d????????,???????d???????d?M??,?5???? ?????d???4 [4] ,???;?????T?????????????8,???T?? ?d???????????9,???N?a?????i?????0???????????d ???V?????????????????/ [5] ?H ?S??????????,?d???????C?????)FDP?????? ?9??????HIE??????????,?k???????????/,?mFDP ??HIE???????????????????????T???????G?????? ???/?H?????????9???H [???I???=] [1]?????(.???9?????d?????d?T?????????????????(??[J].?t?? ????????,1997,35(2):992101. [2]?7????,?7????,????,??.???C???????t?4???????9?????d???? ?d?T??????????[J].????????????,2002,20(1):17218. [3]??????,?????9.?9?????E?????????9?????d?????d?T??48?? ????????[J].???+????,2002,42(30):51252. [4]??????,???<,?7?[??,??.1,62[ J].???/????????????,2003,18(7):5162518. [5]??????.?????d?????????????9?????d?????d?T?????9?????? ??[J].???+????,2002,42(14):29. (???????9:2007212230) ???????t???? ?d?????1???I?????????????K?? AAD31?????????? ??????,?A???? (???+?t?????d???S??????????,???+????250001) ????2005??6?)??2007??8?),?T?????/?d?????1???I???? (IVIG)???????????9?7?????d????(AAD)????32??,???? ???K?H?????????2?H ????????:62?????E???9???d?????/?T?????????????? ?9?????9AAD??????,??37??,??25??;????<6?k?)21 ??,??3??28??,??7??13???H??????:?,???????9??17??, ?G?d?c?m????25??,????20???H???<?)AAD?????P??:?? ?/???9?73d???,,????????,?????n??????,8?3?:/d,????2 d???,,?n???????4????,???/???9?7?n?????????????a?????4 ??????????????,???????????????????9???????????????? ???d?????H?(?????????(?????????a???????E31??,?V???? ?S???????]?????d?H ?????????V?????????/???9?7,???/????D???????? ???????9?7?????T,5(??),?(3?:???N,?;???????9 ?4?????4???????????H???????/???????,???/IVIG200??400 mg/(kg??d),???/3??5d?H?????V???????5?????????????9?? ???)?????H???/PEMS?????????H???????????d??????t?? ???H????????I?=0.05?H ????:???????a???????????5???????(?M??(2137?? 0182)d?4(4156??1134)d,P<0105;?????9?????)?g????(4125 ??0171)d?4(6118??1147)d,P<0105?H ????:AAD?????9?a?0?????7?]??,???????c???9?7?? ?N?)?(???/?H???????????P???]?7?4?????n???????/?????1 ???n,???????]?????9?7?????????S??,???t???????????] ?7?4?????]?7?4???????7?????]?7???H?????????????7?????? AAD???0,?]?????????]?7???????HAAD?0???9?????/???9 ?7?a5??10d,???????????????9???i???H???????0?????? ???4??????,?????]???C?d????,???[?????????4?????????4?? ???n?k???d?????H ?/?????9???0?k?????????9AAD,???????????????? ???H?S?????????????a???D????????,????IVIG??AAD?? ?????P?H????????:V?IVIG?????H?d?????a??????(???7)?? ?)?a??????Fc????,???a?J??????????Fc???????),?????J ???????J????????;V????A????7m?????????N?)?????????? ???9,?]?g????????????;V??????t?d???????????n?4?J???? ???????/?H 36 ?????+????2008???S48???S5?9?? ?? :AA 0mg/kgd