NMDA受体参与皮层内突触结构和功能的调节

NMDA受体参与皮层内突触结构和功能的调节 NMDA受体参与皮层内突触结构和功能的 调节 ? 104? 病理痛提供新的思路. 参考文献 1CampbellJN,Meyer1RA.Mechanismsofneuropathicpain. Neuron,2006,52:77,92. 2MillanMJ.Descendingcontrolofpain.ProgNeurobiol, 2cl02.66:355,474. 3ZhuoM,GebhartGF.Biphasicmodulationofspinalnoci— ceptivetransmissionfromthemedullaryraphenucleiinthe rat.JNeurophysiol,1997,78:746,758. 4孙瑞卿,王韵,万有,等.神经源性痛的机制研究进展. 中国疼痛医学杂志,2003,9:105,110. 5PorrecaF,OssipovMH,GebhartGF.Chronicpainandme? dullarydescendingfacilitation.TrendsNeurosci,2002, 25:319—325. 6BeeLA,DickensonAH.Rostralventromedialmedullacon— trolofspinalsensoryprocessinginnormalandpathophysio— logicalstates.Neuroscience,2007,147:786,793. 7PorrecaF,BurgessSE,GardellLR,eta1.Inhibitionof neuropathicpainbyselectiveablationofbrainstemmedullary cellsexpressingthemu?opioidreceptor.JNeurosci,2001, 21:5281—5288. 8BurgessSE,GardellLR,OssipovMH,eta1.Time?depend? entdescendingfacilitationfromtherostralventromedialme— dullamaintains,butdoesnotinitiate,neuropathicpain.J Neurosci,2002,22:5129,5136. 9Vera?PortocarreroLP,ZhangET,OssipovMH,eta1.De? scendingfacilitationfromtherostralventromedialmedulla maintainsnerveinjury—inducedcentralsensitization.Neuro? science,2006,140:1311,1320. 生理科学进展2o08年第39卷第2期 10SunQ,TuHY,XingGG,eta1.Ectopicdischargesfrom injurednervefibersarehishlycorrelatedwithtactileallo? dyniaonlyinearly,butnotlate,stageinratswithspinal nerveligation.ExpNeurol,2005,191:128,136. 11XieW,StrongJA,MeijJT,eta1.Neuropathicpain:early spontaneousafferentactivityisthetrigger.Pain,2005, 116:243—256. 12SuzukiR,MorcuendeS,WebberM,eta1.Superficial NK1一expressingneuronscontrolspinalexcitabilitythrough activationofdescendingpathways.NatNeurosci,2002, 5:1319,1326. 13SuzukiR,RyghLJ,DickensonAH.Badnewsfromthe brain:descending5-HTpathwaysthatcontrolspinalpain processing.TrendsPharmacolSci,2004,25:613—617. 14LiuFY,XingGG,Quxx,eta1.Rolesof5- hydroxytryptamine(5?HT)receptorsubtypesinthein? hibitoryeffectsof5-HTonC?fiberresponsesofspinal widedynamicrangeneuronsinrats.JPharmacolExpT? her,2007,321:1046,1053. 15OatwayMA,ChenY,WeaverLC.The5-HT3receptorfa? cilitatesat—levelmechanicalallodyniafollowingspinalcord injury.Pain,2004,110:259,268. 16RahmanW,SuzukiR,WebberM,eta1.Depletionofen— dogenousspinal5-HTattenuatesthebehaviouralhypersen— sitivitytomechanicalandcoolingstimuliinducedbyspinal nerveligation.Pain,2006,123:264,274. 17McCleaneGJ,SuzukiR,DickensonAH.DoesaSingleIn— travenousinjectionofthe5HT3receptorantagonistondan? setronhaveananalgesiceffectinneuropathicpain.’?A double?blinded,placebo?controlledcross?overstudy. AnesthAnalg,2003,97:1474—1478. NMDA受体参与皮层内突触结构和功能的调节 在中枢神经系统内神经细胞的树突棘是突触信息传递的重要部位,树突棘的体 积和密度影响神经环路 的功能.2007年美国加利福尼亚大学的SilaK.Uhanir等人在皮层NR1亚基(是 NMDA受体的必要组分) 基因敲除的小鼠上发现NMDA受体对树突棘的发育有重要影响.急性分离出生 后三周内小鼠的脑片,用电 压钳全细胞的,发现在皮层2/3层的锥体细胞中,AMPA受体介导的微 小兴奋性突触后电流(mEP. SC)的幅度和频率均明显增大.通过共聚焦显微镜(con_focalmicroscopy)和电镜 成像技术,发现这些锥体细 胞树突棘的密度降低而且树突棘头部体积增大,同时突触前的轴突终扣体积和 突触后致密区均明显增大. 以上实验结果明,在皮层发育过程中NMDA受体介导的信息可以调节树突棘 的密度和体积.作者认为, 在大脑皮层的发育过程中,NMDA受体介导的信息参与皮层内突触结构和功能 的调节. (ProcNatlAcadSci,2007,104:19553,19558)(张建军于龙川)