颈动脉内中膜厚度和血流剪切力的相关性研究

颈动脉内中膜厚度和血流剪切力的相关性研究 颈动脉内中膜厚度和血流剪切力的相关性 研究 2006???w17?????nJChinClinMedImaging,2006,Vol.17,Supplement ?????i???Z?????????O?K???C?????????x?V?? ???? 1 ?M???T?T 1 ?M?????? 2 ?M?H???? 2 ?h1.???????P?F?F???F?????????M?????????r??830000?82.?w?????F?x???m???F?????????M????????710038?i [????]?????t?????????i???Z???????hIMT?i???O?K???C????????A0?<?????????t???r???J??????????????20?????????? ???i???Z???????M???Z?R10???M??10???M?????????h34.3??10.6?i??A0?M?????????1?O?????O?K???C???h6?m?i?M???????????I?t6?m= 6???4??VmFDA0?t???????????J???s?????Z?????????O?K???C????????A0?????t20???????????????Z???????P?h0.68??0.06?imm?M?? ?????????O?K???C???P?h12.2??3.4?idynesFcm 2 ?M???7???d?b?T?????hy=0.8174-0.0117x?Mr=-0.67?iA0?????t?w?V?????d?????i???Z?? ???????O?K???C?????T?????M?????O?K???C?????????????i???Z???????????.?M?????????T???i???R???.?i?????I??A0 [???H??]?????i?8???????? Correlativestudyofintima-mediathicknessandwallshearstressincommoncarotidartery ZHUANGLei1 ,WANGWei-juan1 ,DUANYun-you2 ,RUANLi-tao2 (1.DeparmentofMedicalImaging,UrumuqiGeneralHospitalofPLA,Urumuqi830000,ChinaT 2.DepartmentofUltrasoundDiagnosis,TangduHospital,FourthMilitaryMedicalUniversity,Xi4pan710038,China) Abstract:Objective:Toexploretherelationshipbetweenintima-mediathickness(IMT)andwallshearstressincommon carotidartery.MaterialsandMethods:Intima-mediathicknesswasmeasuredbyhighresolutionultrasoundincommon carotidarteryof20healthyvolunteers,10males,10females,averageage(34.3??10.6)y.Wallshearstresswascalculatedas thefollowingequation:6?m=6???4??VmFD.Results:ThemeanIMTofcommoncarotidarterywas(0.68??0.06)mm,themean6?m was(12.2??3.4)dynesFcm 2 .ThemeanshearstresswasinverselyrelatedtoIMTofr=-0.67.Conclusion:Ourstudyindicatesthat IMTofcommoncarotidarterywasinverselycorrelatedtowallshearstress,demonstratingtheroleofshearstressinthepro- cessofIMT. Keywords:carotidarteries[ultrasonography ?w?V?????r???J??????????????20???????? ?????i???Z???????????????O?K???C???M???r?d?? ???7??????????A0 1?????d???? ?V???????7??20?????????:?7?M?R10???M?? 10???M?????????h34.3??10.6?i??A0?O?i?????????d?b ???O???????M???????????(???T?.?????M?7???O?7 ?F??????A2?u???i??A2???????0???????O???M?n???C ?C???(?7?S???w?V??A0 ???????????rAcuson128XPF10?j?a???????? ???M???W????7.5MHz?M?????7???????????v???n?? ??A0?????????M???????i?61??2cm?1?b?P?????i?? ???M?????j??R?????????????g?4?k?T?????8?Y?d ?????????i?????????M?J?k????????A2?d??A2?????? ?Z???????M???????XA0?????????i???????x?O?K?T ?????J???R?????????????Z???M?x?I???P???????? ??F3?M?7???b?P???N?7?????M????????3?f?????? ?T???????XA0 ????????????2?I???????????????Z???i?? ?O?M?M?????????4?????h35IUFml?iA0???r?????O???? ?????????O?????4???h?C????225s-1 ?iA0?O?K???C?? ?h6?m?i?????????I?t6?m=6???4??VmFD?M???Z6??P?O???? ?4???MVm?P?????i???????x?O?K?T???MD?P?g?4?k ?T?O??????A0???????q?????IR=6???Vm??rF1 .056kgFcm3 ?8r?P?O ??????A0R<1000???P?U?????5?KA0 ???????1?J?t?O?i????????????x??s???P?MIMT ??6?m?s???<???????r?????????J???MP<0.05???P ?i???????I??A0 2???? 20?????????:?7???O?7?F??????A2?u???i???? ???????0?????W???J?k?P?h5??6?iFLA2 ?h??5?iFL???h??36?iFL?h???iA0?? ?????P5??A0?????????q?O???M?????i?? 8???? 2 4.40.4mmol 1.140.2mmol1.080.mmol1 18.429.840 2006???w17?????nJChinClinMedImaging,2006,Vol.17,Supplement ??1?????i???Z?????????O?K???C?????????????hr=-0.67?iA0 ??120?????????:?7?O?K?????????T?.?C?C???????? ?6???Xxs ?F???????hmmolAL?i3.72??6.104.540.46 ?u???i???hmmolAL?i0.41??2.121.140.52 ???????0?????hmmolAL?i0.63??1.381.080.36 ???Z???????hmm?i0.57??0.800.680.06 ?O?K???C???hdynesAcm2 ?i5.0??18.712.23.4 ??????121??246185.429.8 ??IMT?P?h0.68??0.06?imm?M?????O?K???C???P?h12.2?? 3.4?idynesAcm2 ?M?????i???Z?????????O?K???C???? ?d?b?T?????hr=-0.67?M??1?iA0 3???? ?O???Z???O???T?????O?????4???M???r???O?? ???????????????????M?r?????????n?O???T???? ???????P?O?K???C??A0???C???e???????O???????? ???.?M?M?V?U?????O???????????i???R???.?????S ???J?T?J?q???????????4A0 ?O???????????????????????2?????A?O?K?? ?C?????????M???C?????x?I???q???????????????? ????A0???i?????O?K???C?????w?P1??6dynesAcm2 ?M?? ?i???????w?P10??70dynesAcm2 A0?S?t???????d?O?K ???C?????O???????????????x?M?s???t?????N???O ?K?,???????????O?K???C?????????????M?????I?? ?????i?4?u???????????????i?????????O???i [1] ?M ?O???????t?????x???4?????C???l???????O???2?8 ?????N???O?K?????a?.?O?????4???l???M?????? ?C?????????????M?O?????????t?????v?I?????e?? ?C??A0?O?????????6?????r???????U?J???C?????2 ?r15??20dynesAcm2 ?M???C???????????a???????l?? ???????????O???????????M?M?V?t???O?????????? ?x?W???M?x?NA0 ?????????????M???O?K???C?????T?c???.?,?? ???.???O?????????????????t???T?????q??A0?t?? ?.?????U???????x?4?????i?J?K?=???M?????????O ?K???C????????cGMP?n??A2?O??????????NO?h ?m???F?x????A2mRNA???????????r?h?m????[2] ?8?d ???????????M?O???????????????4A0?????t?????4?O ?????????O?K???C?????????(???????6?????r???? NO?h?m?????Y?5?F??A0???O?K???C?????2?2???? ?248?I?????n?O?????????????T?t????18?e?M?M ???W?i?O?????<?J???????????M?????O?????????? ?????M?????O???O???O?,???mA0 ?????????O?K???C?????O?????????V???t???Z ?????????J?=??A0?w?V?????r?????t???????????? ?M?i???????????????????????????i???Z???????? ?O?K???C???????????M?????????i???Z???????d?O ?K???C?????d?b?T?????hP<0.01?iA0???Y?n???????7 ?O?7?F??????A2?u???i???W?????r???(?6???M?B?O?K ???C???????r???????k?h5.0??18.7dynesAcm2 ?iA0?O?K?? ?C?????I?M?????????i???Z???????X????A0???d???? ?r???(?????Z?M???T?1?????O?K???C?????2?l???? ?????i???R???.???????x?????M?O?K???C???????P ?s?????T???i???R???.???????????????C?CA0 ?O???????U?????r?O???O?K?????????4???r?l ???F?J???.???J???t???O???F?x???????i?P?T?? ??A0?O?K???C???????.???????S???4A2NO???????4 ???????2?????M???T?N?6?????????i???R???.[3] A0?a ?????????????????i???Z?????????O?K???C?????? ?b???T?????M???r?????t?????????O?K???C?????P ???i???T???i???R???.?,???????????????????C ?CA0 [???6???H] [1]GirerdX,LondonG,BoutourieP,etal.Remodelingofthe radialarteryinresponsetoachronicincreaseinshearstress[J]. Hypertension,1996,27?t799-803. [2]NadaudS,PhilippeM,ArnalJF,etal.Sustainedincrease inaorticendothelialnitricoxidesynthaseexpressioninvivoina modelofchonichighbloodflow[J].CircRes,1996,79?t857-863. [3]TraubO,BerkBC.Laminarshearstress:mechanismsby whichendothelialcellstransduceanathero-protectiveforce[J].Arte- riosclerThrombVascBiol,1998,18?t677-685. 9????