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Crude Radix Polygalae and its Saponin and Honey-stir-????Experimental Research of
baked Radix Polygalae on the ex vitro Intestine Movement Mechanism to Domestic Rabbit
????Abstract:ObjectiveTo approach the Crude Radix Polygalae and its saponin and Honey-stir-
baked Radix Polygalae mechanism of in vitro intestine movement of domestic rabbit.MethodsUsed the in vitro intestine movement experiment, with the biologic function analyzer to record the influenses on ex-
intestines and the intestines which contract were induced by Ach, Histamine and Barium Chloride; Got the ex-
intestines amplitude and the frequency, and calculated the inhibition ratio.ResultsCompared with the control, the Crude Radix Polygalae and its saponin could all remarkably inhibit the exintestines' movements, the inhibition ratios were remarkably larger than that of Honey-stir-
baked Radix Polygalae(P??0.01); and the Crude Radix Polygalae and its saponin could all remarkably inhibit the movements of the intestines which contract were resulted
with Ach, Histamine and Barium Chloride; the inhibition ratios were remarkably larger than Honey-stir-baked Radix Polygalae(P??0.01); Honey-stir-
baked Radix Polygalae also inhibited the excitability contract with the exintestines and the intestines which contract were induced by the Barium Chloride (P??0.05).Conclusion?ÙCrude Radix Polygalae and its saponin can inhibit the ex vitro intestine's movement of the domestic rabbit;the mechanism is possibly related with two factors, the one is Crude Radix Polygalae and its saponin compete with Ach and Histamine and block M, H1 receptor; the next is direct inhibition of ex vitro intestine excitability, and the inhibitory action is inreversible.?ÚHoney-stir-
baked Radix Polygalae can directly inhibit the ex-
intestine movement but the inhibitory action is remarkably less than Crude Radix Poly
galae and its saponin.
????Key words:Crude Radix Polygalae; Saponin; Honey-stir-
baked Radix Polygalae; Ex vitr intestine
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?????Û1?Ý Ð??çºñ.ÖÐÒ???Ñ?,µÚ2?æ?ÛM?Ý.ÉϺ?:ÉϺ??ÆÑ???Êõ?ö?æÉç,1997,387.
?????Û2?Ý ÐìÊåÔÆ.Ò?ÀíʵÑé????Ñ??ÛM?Ý.?????ºÈËÃñÎÀÉú?ö?æÉç,2001?º1834.
?????Û3?Ý Íõ ??,?ù ?ê,ÁõÏÍÎä??µÈ.ÉúÔ?Ö???Óë?Ê?Ý??Í?ÅäÎé?ÈÀý?ÔÐ?ÊóÎ???ÔË??µÄÓ?Ïì?ÛJ?Ý.ÖÐÒ?Ò?ÀíÓëÁÙ??,2002,18??5???º27.
?????Û4?Ý Íõ ??,ÎâêÍêÍ.ÉúÔ?Ö???Æä×ÜÔíÜÕÓëÃÛÔ?Ö?µÄ??ÐÔ??ÐÔ?È?ÏÑÐ???ÛJ?Ý.ÖÐÒ?Ò?ÀíÓëÁÙ????2004??20??6???º21.
?????Û5?Ý Îä ÔÆ??Ìï ?Õ.ÉúÔ?Ö?ÓëÃÛÔ?Ö??ÔÐ?ÊóÎ???ÔË??µÄÓ?Ïì?ÛJ?Ý.ÖÐ?úÒ?Ñ?ÑÐ??ÓëÁÙ????2004,2(17):5.
?????Û6?Ý BOLTON T B ,CLARKJ P. Effects of histamine ,high Potassium and carb
ochol on K efflux from longitudinal muscle of guinea-Pig intestine?ÛJ?Ý.J Physiol,1981,320:347.
?????Û7?Ý ÅíÎÄîì.Ô?Ö?ÔíÜÕH?ÔÀëÌå??Æ?????ÓëÐÄÔàµÄ×?ÓÃ?ÛJ?Ý.ÖÐ?úÒ?Ñ?ÔÓÖ???1999??34??4???º241.