BioRepair修复牙齿珐琅质牙膏

BioRepair修复牙齿珐琅质牙膏 摘译自 Prof. Norberto Roveri 诺勃特罗韦里教授之 BioRepair Plus 科学研究报告 研究单位:义大利波隆那大学研究所LEBSC 1 BioRepair 修复牙齿珐琅质牙膏 Prof. Norberto Roveri 诺勃特罗韦里教授? I am pleased to present BioRepair Plus to you. ? 我很高兴介绍BioRepair Plus修复牙齿? BioRepair Plus developed by Coswell Research 珐琅质牙膏给您 Laboratories in collaboration with the LEBSC Laboratory of Environmental and Biological Structural ? BioRepair Plus是义大利COSWELL研究 Chemistry at the University of Bologna Italyis the first 实验室与义大利波隆那大学环 境和生物 toothpaste based on bioactive microparticles which 结 构 化 学实验室合作 研发的第一个牙 thanks to their composition are ableto penetrate into the 膏，其基础上 组成的生物活性微粒，能 microscopic defects on the enamel and dentine surfaces 渗透 到牙齿珐琅质的微观缺陷和牙本质 performing an effective remineralising and reparative 面，执行一个有效的再矿化和修复。 treatment. ? 该环境和生物结构化 学实验室LEBSC已 The LEBSC has been operating for thirty years and uses? the most advanced techniques to study the chemical and 运作了30年，采用最先进的技术研究化 biological aspects of mineralization processes of 学和生物方面的钙化组织的矿化过 程， calcified tissues and in particularbone tissue.Enclosed 特别是对骨组织。以下是 一种深入的科 is an in-depth scientific study which supports the 学研究，其证实了 BioRepair的有效性 effectiveness of BioRepair and its MICROREPAIR 和 作 用 。 每 日 使 用 ， action. Used daily BioRepair will repair MICROREPAIR 的 tooth enamel BioRepair牙膏将修复牙齿珐琅质，并 and will make your teeth more healthy – definitely 将使你的牙齿更健康 – 绝对是一个值 something to smile about 得微笑的东西～ Thank you for your time. 感谢你的时间。 Yours faithfully 此致 Prof. Norberto Roveri 诺勃特罗韦里教授 一般和无机化学教 授 Full Professor of General and Inorganic Chemestry “G. Ciamician” Department of Chemistry “湾恰米钱“化学系， 波隆那大学 2 University of Bologna Enamel 珐琅质? Like vertebrate bone tissues teeth are a ? 像脊椎动物的骨组织一样牙齿是一 composite natural material the main component of which is an inorganic 种天然的复合，其主要成分是 carbonated Hydr oxyapatite phase 一种无机碳酸 - 羟基磷灰石层面， representing 65-70 of dentine by weight 占 65-70,的牙本质重量和90,以 and over 90 of enamel by weight. 上珐琅质的重量。 Dental enamel forms the thin outer 牙珐琅质形成我们牙齿 表面的薄薄? ? coating of our teeth and is considered to be the hardest and strongest of all biogenic 的涂层，被认为是最强硬的生物材 materials figure 1. 料(图 1)。 3? Tooth enamel is composed mainly of large ? 牙珐琅质主要由大的，稜形的高晶羟基 prismatic highly crystalline hydroxyapatite 磷灰石微粒，连同一个非常低蛋白成份 microparticles together with a very low protein component figs. 2a and 2b. 组成(图 2a和2b)。 Figure 2a: Enamel structure viewed with Scanning Figure 2b: SEM image: layers of rod-like hydroxyapatite electron microscopy SEM Scale bar5μm. microparticles that form enamel Scale bar1μm. Reproduced with permission from H. Lowestan and S. Reproduced with permission from H. Lowestan and S. Weiner quotOn Biomineralizationquot Oxford University Weiner quotOn Biomineralizationquot Oxford Press 1989. University Press 1989. 图 2a:珐琅质结构效果扫描 图 2b:扫描电镜图 像:层棒状羟基磷 电子显微镜(SEM)(比例尺5μm 灰石微粒 的)。 ，形成珐 琅质(比例尺 1微米)。 经许可转载: Lowestan和S.韦纳， 经许可转载: Lowestan 和S.韦纳，“在 “在生物矿化”，牛津大学 1989年。 生物矿化”， 牛津大学出版社 1989年。 4? In adults enamel does not contain any cells and is therefore not capable of self regeneration. Any damage is irreversible as there is no biological process capable of repairing damaged enamel.? In a similar way dentinefigure 3 exposed to the oral environment cannot be regenerated as new dentine is deposited on the interior surfaces of the crown close to the pulp and not on the outside. For this reason any reparative action must be provided by materials or substances that are Figure 3: Dentine structure viewed extraneous to dental tissue metabolism. These using Scanning substances are either synthetic or are precipitated electron microscopy SEM. The from saliva dentinal tubules can be seen clearly occupied by the? 在成人，珐琅质不包含任何细胞，因此 odontoblast processes and 不能够自我再生。任何损害不可逆转 intratubular fluid implicated. 的，因为目前没有生物过程能够修复受 损的珐琅质。 图 3:，在使用 扫描电子显 微镜显现的牙本质结构的效? 以类似的方式，牙本质(图 3)暴露在 果 (SEM)。在牙本质小管， 口腔环境，不能再生的，新的牙本质沉 可清楚地看到， 它们经过成 积在接近牙骨髓的齿冠的内部表层上， 齿质细胞处理和管内牵连的 而 不是在外面。为此，任何修复行动的 流体所占据。 材料或物质其是与牙齿组织的 代谢无 关。这些物质要麼是合成的或是从唾液 的沉淀中获得。 5 MICROREPAIR ? BioRepair Microparticles? MICROREPAIR ? Ca10-xZnxPO46-yCO3y OH2? The hydroxyapatite microparticles ? Y4-8 CO32- substituted at PO43- X1 MICROREPAIR present in BioRepair Zn2 substituted at Ca2 Plus are completely identical to the mineral ? BioRepair 微粒 that forms dentine and enamel. It is ? 钙(10 - x)的Znx(PO4)(6 - Y)的(碳酸 摄)(OH)2的(是 4-8,碳酸 2 – 取代在 PO4 precisely from this similarity that the 3 - )(x 1的,Zn2 的取代的钙) synthetic micro particles derive their ? Figure 4: Chemical formula for dentine and . enamel remineralising hydroxyapatite capacity to reconstruct dentine and Enamel. microparticles Microrepair. Calcium phosphate and carbonate are present in very? MICROREPAIR similar relationships to those occurring naturally. It is the zinc with its antisepticproperties that is responsible? 存在於BioRepair Plus的羟基磷灰 for the plaque-preventing action. 石微粒(MICROREPAIR )与构 ? 图 4:牙本质和珐琅 质再矿化形成 成牙本质和珐琅质的矿物是完全相 羟基磷灰石微粒(Microrepair ) 的化学公式。磷酸钙和碳酸钙 同的。正是从这个相似，合成的微 与那些自然产生 的物质存在著非常 粒获得重建牙本质和珐琅质的能 类似的关系。锌的抗菌特性主 要是 负责预防牙菌斑的侵入行动。 力。 6? The substance used in ? 用於 BioRepair Plus BioRepair Plus is 的物质是技术上的创 technologically innovative in 新，它以微 粒的形式加 that being in the form of microparticles it has enhanced 强了它的化学反 应。微 chemical reactivity. 粒以释出其组成的钙、 Microparticles carry out their 磷 来履行牙本质的矿化 dentine remineralising action 行动。微粒以他们能附 by releasing their constituent calcium and phosphorous in 著在珐琅质的自然组织 situ. In the case of the enamel 的能力来填补细微裂缝 the microparticles action takes 的珐琅 质。 place via their ability to bond to natural tissues thus filling microgaps in the enamel.。 7 图 5和6:Figures 5 and 6: 微观 MicrorepairMicroscopic Microrepair 微 粒聚集效果，请使用micro-particles aggregates 透射电镜viewed using TEM (透射电 子显微镜)Transmission electron microscopy (比例尺 100微米)Scale bar100 μm 8Transmission electron microscopy (透射电子显微镜)(比例尺 100微米)Scale bar100 μm 图 7和8:微观 Microrepair 微粒聚集效Figures 7 and 8: Microscopic 果请 使用透射电子显微镜Microrepair microparticles 透射电子显微镜aggregates viewed using TEM (比例尺 50，分别为 20微米)。Transmission electron microscopyScale bar50 and 20 μm respectively. 9 Introduction介绍Action mechanismThe enhanced reactivity ofMICROREPAIR microparticles is dueprimarily to the bio-mimetic action ofthese microparticles which have thedistinguishing feature of possessing avery similar chemical composition tothat of enamel and dentine.The X-ray diffraction spectrum ofMICROREPAIR microparticles figure9 shows how the degree ofcrystallinity of the microparticles is halfway between that of enamel anddentine. Figure 9: X-ray diffraction diagrams of enamel red line MICROREPAIR作用机制 microparticles blue line and dentine增强反应的MICROREPAIR 微粒主要是由於对生物模仿动作，这些具有 green line.显著特徵的微粒与组成珐琅质和牙本质的化学成分相似。X射线衍射谱 图 9:珐琅质的X -射线衍射图(红MICROREPAIR 微粒(图 9)显示微粒的 线)， 结晶度是介於珐琅质和牙本质的中间。 MICROREPAIR 微粒(蓝线)和牙本质 10 (绿线)。? The ability to remineralise hard ? 使硬组织再矿化的能力会消除 tissues has an impact on several 对牙齿硬组织造成影响的障碍 disorders that affect the hard tissue 物如: of teeth: ? 1 原组织的再矿化能预防蛀? 1. Prevention of cavities by remineralisation of original 牙 lesions ? 2 掩盖牙本质小管，使牙本?2. Desensitising effect on dentine 质 by covering up dentinal tubules 有抗敏作用? 3. Tartar and plaque prevention 3 具有公认的防腐性能的 thanks to antibacterial action of ? Zn2 with recognized antiseptic 锌， properties 其本身的抗菌作用能预 防牙 结石和牙菌斑。 11Figure 10: the SEM images show the surface of the dentine before treatment a and after treatmentwith MICROREPAIR: 1 minute b 10 minutes and one hour d. They clearly show the progressivegrowth of the apatite microparticles until they completely hide the dentine channels图 10:在SEM图像显示未经过处理的牙本质表面(a)和用 MICROREPAIR 处理后的1分钟(b)，10分钟(c) 及1个小时(d)。他们清楚地 显示了磷灰石微粒的增长过程，直到他们完全掩盖牙本质渠道 Figure 10a Figure 10 b Figure 10 c Figure 10 d 12? Figures 10 a b c and d show the ? 图 10(的A，B，C和 D)显示 progressive action of MICROREPAIR MICROREPAIR 微粒的渐进行 microparticles as they gradually bond securely to the surface of the dentine 动 ，因为他 们逐渐安全地附 blocking the tubules and thus performing 著在牙本质表面，阻塞微小 their effective long-lasting desensitising 管，从而履行其有效且持久的 effect on the dentine. 让牙本质产生抗敏的作用。 The phenomenon can be seen at work a? ? 在使 用BioRepair Plus微粒 few minutes after the BioRepair Plus microparticles have been applied which 几分钟后就可看出上述的现 means that the microparticles 象，这意味 著微粒再矿化和抗 remineralising and desensitising action 敏行动开始后，只需使用 适量 begins after only a few applications of 的BioRepair Plus牙膏。 BioRepair Plus toothpaste. ? 一个类似的机制可以看出珐琅? A similar mechanism can be seen on the surface of the enamel where there are 质的表面在有微小的缺陷或简 microscopic defects or simple surface 单的不规则表面，BioRepair irregularities as the BioRepair Plus Plus微粒如何来开始他们的 microparticles are laid down and begin 再结晶过程。 their recrystallisation process. 13 13? The Zinc release mechanism is ? 锌释放机制是 极具创新性 extremely innovative as it takes 的，因为它.