呼出气一氧化氮在支气管哮喘中的变呼出气一氧化氮在支气管哮喘中的变
呼出气一氧化氮在支气管哮喘中的变化及与肺功能的相关性
傅佩芳李譞谈敏黄美珍王昌惠
目的 探讨呼出气一氧化氮(FENO)在哮喘各期中的变化及与肺功能的关系。 方法 对急性发作期、慢性持续期、临床缓解期共计54例哮喘患者及19例健康人进行FENO、第1秒用力呼气量( FEV1)检测。 结果 FENO、FEV1在哮喘急性发作期[(57.59±32.24)ppb和(1.72±0.33)L]、慢性持续期[(40.02±15.68)ppb和(2.41±0.23)L]、缓解期[(26.71±6....
呼出气一氧化氮在支气管哮喘中的变
呼出气一氧化氮在支气管哮喘中的变化及与肺功能的相关性
傅佩芳李譞谈敏黄美珍王昌惠
目的 探讨呼出气一氧化氮(FENO)在哮喘各期中的变化及与肺功能的关系。
对急性发作期、慢性持续期、临床缓解期共计54例哮喘患者及19例健康人进行FENO、第1秒用力呼气量( FEV1)检测。 结果 FENO、FEV1在哮喘急性发作期[(57.59±32.24)ppb和(1.72±0.33)L]、慢性持续期[(40.02±15.68)ppb和(2.41±0.23)L]、缓解期[(26.71±6.07)ppb和(2.82±0.29)L]及对照组[(14.74±3.42)ppb和(2.93±0.13)L]之间比较,除FEV1在缓解期与对照组比较差异无统计学意义(P>0.05)外,差异均有统计学意义(F=19.555,163.096,P<0.01)。急性发作期FENO与FEV1之间存在负相关(r=-0.666,P=0.005),慢性持续期(r=-0.288,P=0.176)及缓解期(r=-0.246,P=0.457)的FENO与FEV1无相关性。 结论 支气管哮喘患者FENO值增高,可用于评估哮喘的控制程度。
一氧化氮;哮喘;呼吸功能试验
Changes of fractional exhaled nitric oxide and their relation with lung function in bronchial asthmaFUPEI-fangLI XuanTAN MinHUANG Mei-zhenWANG Chang-huiDepartment ofRespiratory, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai 200072, China
Objective To investigate the changes of fractional exhaled nitric oxide (FENO)) and their relation with lung function in bronchial asthma. Methods FENO and forced expiratory volume in the first second (FEV1) were measured during the periods of acute onset, chronic persistence and paracmasis in 54 patients with asthma and 19 healthy persons. Results There were significant differences in the levels of FENO and FEV1 among the course of acute onset [(57.59 ± 32.24) ppb and (1.72± 0.33) L], chronic persistent course [(40.02 ± 15.68) ppb and (2.41 ± 0.23) L],paracmasis [(26.71±6.07) ppb and (2.82±0.29 )L]and control[(14.74±3.42 ) ppb and (2.93±0.13)L] (F=19.555, 163.096, P<0.01) except for the levels of FEV1 between paracmasis and control group(P>0.05). The negative correlation between FENO and FEV1 was found in the course of acute onset(r=- 0.666, P = 0.005 ), but not in the chronic persistent course ( r = - 0.288, P =0.176) and paracmasis(r=-0.246, P=0.457). Conclusions The level of FENO is increased and may be useful to evaluate control degree in patients with asthma.
Nitric oxide; Asthma; Respiratory function tests
DOI: 10. 3760/cma. j. issn. 0254-9026. 2012. 06. 010
作者单位:200072 上海,同济大学附属第十人民医院呼吸科
FENO水平明显高于已
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