载脂蛋白e拟肽能削减漫溢性脑毁伤惹起的神经细胞凋亡吗？[新版]

载脂蛋白e拟肽能削减漫溢性脑毁伤惹起的神经细胞凋亡吗？[新版] 载脂蛋白E拟肽能减少弥漫性脑损伤引起的神经细胞凋亡吗, 大多数弥漫性脑损伤患者不适合手术，需寻找更有效的神经保护剂来治疗。载脂蛋白E在抑制慢性神 经变性过程中发挥重要作用，但其不能通过血脑屏障。而载脂蛋白E拟肽是较小的含有12个氨基酸的 肽段，可通过正常和受损的血脑屏障，目前对其是否有保护弥漫性脑损伤后神经功能的作用还不清楚。 河北联合大学附属医院李建民教授领导的团队进行了一项研究。发现尾静脉注射高低剂量的载脂蛋白 E拟肽(0.6mg/kg和1.2mg/kg)可改善弥漫性脑损伤大鼠的学习记忆功能，且通过抑制ERK1/2/Bax- 线粒体介导的凋亡途径可防止弥漫性脑损伤引起的神经细胞凋亡。此项研究成果发表在2014年3月第5 期的《中国神经再生研究(英文版)》杂志中。 1Article: " Apolipoprotein E mimetic peptide protects against diffuse brain injury " by Yaning Zhao, Jianmin 21111111 College of Rehabilitation, Li, Qiqun Tang, Junling Gao, Changxiang Chen, Liwei Jing, Pan Zhang, Shuxing Li ( Hebei United University, Tangshan, Hebei Province, China; 2 Affiliated Hospital of Hebei United University, Tangshan, Hebei Province, China ) Zhao YN, Li JM, Tang QQ, Gao JL, Chen CX, Jing LW, Zhang P, Li SX. Apolipoprotein E mimetic peptide protects against diffuse brain injury. Neural Regen Res. 2014;9(5):463-473. 欲获更多资讯: Neural Regen Res Does apolipoprotein E mimetic peptide reduce neuronal apoptosis induced by DBI? Because the majority of patients with diffuse brain injury are not suitable candidates for surgery, neuroprotective agents are of great importance. Apolipoprotein E exerts a neuroprotective effect against brain injury, but synthetic apolipoprotein E cannot cross the blood-brain barrier, thus limiting its application.It has been reported that apolipoprotein E (138–149) mimetic peptide can cross the blood-brain barrier in both normal and injured brain. However, its impact on neurological function following diffuse brain injury is still unclear. Prof. Jianmin Li and team from the Affiliated Hospital of Hebei United University in China conducted a relevant study. These researchers found that apolipoprotein E-derived therapeutic peptide (0.6mg/kg and 1.2mg/kg) improved synaptic stability and improved learning and memory performance after diffuse brain injury. Furthermore, apolipoprotein E mimetic peptide protected against brain injury by reducing oxidative stress, thereby suppressing the ERK1/2-Bax mitochondrial apoptotic pathway and decreasing neuronal death. These results have been published in the Neural Regeneration Research (Vol. 9, No. 5, 2014). 1Article: " Apolipoprotein E mimetic peptide protects against diffuse brain injury " by Yaning Zhao, Jianmin 21111111 College of Rehabilitation, Li, Qiqun Tang, Junling Gao, Changxiang Chen, Liwei Jing, Pan Zhang, Shuxing Li ( Hebei United University, Tangshan, Hebei Province, China; 2 Affiliated Hospital of Hebei United University, Tangshan, Hebei Province, China) Zhao YN, Li JM, Tang QQ, Gao JL, Chen CX, Jing LW, Zhang P, Li SX. Apolipoprotein E mimetic peptide protects against diffuse brain injury. Neural Regen Res. 2014;9(5):463-473.