腔隙性脑梗死论文：腔隙性脑梗死 化瘀双补法 抗栓胶囊 临床研究

腔隙性脑梗死论文：腔隙性脑梗死 化瘀双补法 抗栓胶囊 临床研究 腔隙性脑梗死论文:腔隙性脑梗死 化瘀双补法 抗栓胶囊 临床研究 【中文摘要】探讨化瘀双补法治疗腔隙性脑梗死的作用机理,验证以化瘀双补为立法原则所制之抗栓胶囊在治疗腔隙性脑梗死方面的疗效性与安全性,并为该药在临床推广应用提供依据。:将符合纳入的60例腔隙性脑梗死患者随机分为2组。治疗组30例,在基础治疗下加服“抗栓胶囊”;对照组30例,在基础治疗下加服维脑路通片。治疗两个疗程(14天为一疗程,疗程间停药两天)。观察两组患者治疗前后神经功能缺损评分、中医证候积分、血脂、血液流变学等指标还有大脑中动脉的经颅多普勒(TCD)检查变化以及安全性。统计分析由SPSS17.0软件进行处理,计量资料采用t检验,计数资料采用χ2检验,临床疗效比较采用秩和检验。结果:?临床疗效:治疗组总有效率为93.33%,明显优于对照组(80%),差异具有统计学意义(P<0.05)。?神经功能缺损评分:治疗后治疗组评分低于对照组,差异有高度统计学意义(P<0.01)。?中医证候:治疗组各项中医证候改善明显优于对照组,差异具高度统计学意义(P<0.01)。?血脂:治疗组TC、TG以及LDL-C各数值与对照组比较明显降低,差异具有高度统计学意义(P<0.01)。?血液流变学:治疗组血液流变学各指标数值与对照组比较,均明显降低,差异有高度统计学意义(P<0.01)。?经颅多普勒超声(TCD):治疗组对大脑中动脉平均血流速度的提高明显优于对照组,差异有高度统计学意义(P<0.01)。结论:化瘀双补法是治疗 腔隙性脑梗死的有效中医治法,其方药抗栓胶囊临床疗效确切安全, 服用方便,值得临床推广应用。 【英文摘要】:To explore mechanism of action on treatment of Lacunar Infarction with tonifying Qi and blood and resolving stasis, verified the curative effect and security of Kangshuan capsule, and the evidence for clinical popularization of the medicine can be provided.Methods:According to inclusion criteria,60 patients were randomly classified into two groups:the therapy group with 30 cases were given Kangshuan capsule besides basic therapy, the comparison group with 30 cases were given Weinaolutong tablets besides basic therapy. There were two courses of treatment,14 days for one, and two days discontinuation between two periods. Observe patients diversity and security before and after treatment on neurologic deficits evaluation, TCM syndrome integral, indices, blood lipid, hemorheology and TCD. Statistical analysis from SPSS17.0 software processing, the measurement data using t-test, counting material using X2 test and the Wilcoxon were using on clinical curative effectResults:?n the clinical effect, the total effective rate of the treatment group was better than control(90%,76.67%), with statistically significant difference(P<0.05).?The neural function defect scale:score of treatment group below the control group, with highly statistically significant differences(P<0.01).?TCM syndrome:various syndromes in treatment group improved significant than in control group, with highly statistically significant differences(P<0.01).?lood lipid:TC,TG and LDL-C in treatment group were obviously lower than controls, with highly statistically significant differences(P<0.01).? emorheology:treatment group indexes compared with the control were significantly lower, with highly statistically significant differences(P<0.01).?CD:the speed of average blood flow in the brain artery in treatment group significantly better,with highly statistically significant differences (P<0.01).Conclusion:The remove blood stasis and double replenishing method is an effective TCM treatment,and the kangshuan capsule is curative effect precisely and safety, deserve application in clinical. 【关键词】腔隙性脑梗死 化瘀双补法 抗栓胶囊 临床研究 【采买全文】 1.3.9.9.38.8.4.8 1.3.8.1.13.7.2.1 同时提供论文写作定制和论文发表服务.保过包发. 【说明】本文仅为中国学术文献总库合作提供，无涉版权。作者如有异议请与总库或学校联系。 【英文关键词】Lacunar infarction Tonify Qi and blood and Resolve stasis Kangshuan capsule The clinical research 【目录】化瘀双补法治疗腔隙性脑梗死的临床研究 缩略语表 4-5 摘要 5-6 ABSTRACT 6-7 引言 8-9 文 献综述 9-30 1 腔隙性脑梗死的西医研究现况 9-18 1.1 概念由来及病理特点 9 1.2 临床表现与分型 9-11 1.3 发病危险因素 11-13 1.4 诊断 13-15 1.5 与大血管狭 窄的关系 15 1.6 并发症的研究 15-17 1.7 治疗、预后 及预防 17-18 2 祖国医学对中风轻证的认识 18-30 2.1 历代医家予中风病之灼见 18-24 2.2 浅论积损正衰之病机 24-27 2.3 现代中医对腔隙性脑梗死的研究 27-30 临 床研究 30-39 1 资料与方法 30-33 1.1 病例来源与一 般资料 30-31 1.2 研究及观察方法 31-33 2 诊断标准 与病例选择标准 33-35 2.1 中医诊断标准 33-34 2.2 西医诊断标准 34 2.3 病例纳入标准 34 2.4 病例排除 标准 34-35 2.5 剔除及脱落标准 35 3 临床疗效分析 35-38 3.1 临床总疗效比较 35-36 3.2 神经功能缺损 程度评分比较 36 3.3 中医辨证气虚血瘀各项证候积分比较 36-37 3.4 血脂水平比较 37 3.5 血液流变学指标变化 比较 37-38 3.6 TCD示大脑中动脉血流速度变化比较 38 4 安全性观察 38-39 讨论 39-48 1 导师治疗 腔隙性脑梗死的理论依据 39-40 2 抗栓胶囊的组方原理及方 药分析 40-45 3 化瘀双补法治疗LI的临床疗效评价 45-46 4 对中医药治疗LI的思考与展望 46-48 结论 48-49 致谢 49-50 参考文献 50-57 附表 57-62 攻读硕士期间发表的论文 62-64 个人简历 64