胞二磷胆碱论文（Cell two p choline）

胞二磷胆碱论文（Cell two p choline） 胞二磷胆碱论文(Cell two p choline) [Abstract] Objective To investigate the clinical efficacy of citicoline two in the treatment of gravidarum gravidarum. Methods from March 2007 to March 2010, 46 cases of pregnancy induced vomiting were randomly divided into experimental group 24 cases and control group 22 cases. The treatment effect and recurrence rate of two groups were compared. Results the effective rate of the experimental group was higher than that of the control group (P<0.01), and the recurrence rate was lower than that of the control group (P=0.002<0.01). Conclusion the effect of two p choline on the treatment of gravidarum gravidarum is better. Keywords pregnancy gravidarum vomiting; cell two phosphorus choline Gravidarum vomiting is a common disease in obstetrics and gynecology. Patients suffer from severe early pregnancy, frequent vomiting and inability to eat, which lead to electrolyte disturbances, acidosis, damage to vital organs and even life-threatening. Therefore, how to suppress the symptoms of the upper digestive tract and restore the diet is of great significance. Traditional treatment methods are usually treated with sedation, infusion, Neiguan and so on. The effect is poor. Our hospital from March 2007 to March 2010 for 24 cases of pregnancy diagnosed vomiting in hospitalized patients, the use of cell two phosphorus choline treatment obtained good results, is reported as follows. Data and methods 1. general data 46 cases, pregnant women 1~3 times, age 19~36 years old, 6~12 weeks pregnant, all by B ultrasonic examination diagnosed as early pregnancy, ruled out other causes of vomiting. All the patients had severe nausea and vomiting, and a small amount of food vomiting, urine ketone body positive, serious electrolyte disorders. The patients were randomly divided into two groups, the experimental group 24 cases, the control group 22 cases, the two groups of pregnant women, pregnancy, age and gestational age, the general situation was not statistically significant (P>0.05), comparable. See table 1. Table 1 Comparison of general situation between two groups of pregnant women 2. treatment method, the experimental group uses the cell two phosphorus choline 500 mg, joins 500 ml glucose, drops QD, 3~5 days is a course of treatment. Since most patients in this group are unable to eat, they need fluid therapy to adjust the electrolyte and acid-base balance. The control group: according to specific conditions, sedation, infusion, Neiguan, closed and other symptomatic support treatment. 3. curative effect standard is effective: vomiting disappears, have or do not have disgusting symptom, can eat a little bit more meal, stop infusion, the ketone is negative. Invalid: still vomiting, relying on fluid replacement to maintain energy needs, positive urine ketone bodies. Recurrence: vomiting disappeared, can eat, urine ketone negative, 1 weeks later, severe nausea and vomiting occur again, a small amount of food that spits out, urine ketone positive, and even electrolyte disorders. 4. statistical analysis of measurement data with (- + s), using t test, count data by using the 2 test or Fisher's exact test, P<0.05 was statistically significant. Result The experimental group was effective in 22 cases, ineffective in 2 cases, the effective rate was 91.67%. The control group was effective in 13 cases, ineffective in 9 cases, the effective rate was 59.09%, and the difference between the two groups was statistically significant (chi, 2=6.69, P<0.01). In the experimental group, 3 cases relapsed, the recurrence rate was 13.64% (3/22); the control group relapsed 9 cases, the recurrence rate was 69.23% (9/13). The two groups were examined by Fisher exact probability test (P=0.002<0.01), the difference was statistically significant. It is not clear that the pathogenesis of gravidarum gravidarum is related to endocrine factors, mental and social factors, vitamin deficiency and nerve factors. Under these conditions, the disorder of brain function can stimulate the vomiting center of medulla oblongata and chemoreceptor trigger zone and cause vomiting [1]. Severe vomiting in pregnancy can occur electrolyte disorders, arrhythmia, liver and kidney dysfunction, retinal hemorrhage, and even wemicke encephalopathy, life-threatening. And can increase the incidence of miscarriage and fetal growth restriction, can lead to low birth weight infants. There is no specific drug for the treatment of pregnancy vomiting, but the traditional treatment is not effective. This study showed that the use of two p choline in the treatment of pregnancy vomiting was significantly better than the traditional methods. Cell two p choline can improve the metabolism of brain tissue and promote the recovery of brain function. [2]. Cell two p choline can decrease vascular resistance, increase cerebral blood flow, and improve the respiratory function of brain cell mitochondria, The increase of oxidative phosphorylation and oxygen uptake capacity, increase ATP formation to improve brain metabolism, promote the recovery of brain cell function. Cell two phosphorus choline can improve the metabolism of the central nervous system and chemoreceptor triggered cell in the medulla oblongata and stimulate the production of GABA in the brain, so it can be used to relieve the vomiting symptoms [3]. Vomiting of pregnancy patients to delayed healing, this study shows that application of cytoplasmic two choline in treatment of recurrent pregnancy rate after vomiting was significantly lower than the general traditional method, because the cell two choline have neurotrophic effects, promote brain function recovery, reduce the recurrence of vomiting of pregnancy. As for whether cytoplasmic two choline affect fetal development, has not yet been reported in clinical pharmacology in China, cytoplasmic two choline does not indicate pregnancy or caution, that cell two choline is safe for the treatment of nausea and vomiting of pregnancy. In this case, 22 were delivered at term, and the newborn developed normally. The effect of two p choline in treatment of pregnancy vomiting is obvious, the recurrence rate is low, the method is simple, the price is low, and there is no side effect, so it is worth popularizing. [References] [1], Su Yingkuan, Xu Zeng Yan, Jiang Sen. Practical science of production [M]. Ji'nan: Shandong science and Technology Press, 2004:6. [2] Wu Nongrong. Cell two choline treatment of 6 cases of hyperemesis gravidarum [J]. integrative practical clinical emergency, 1996, 3 (11): 502. [3] Luo Yanhong, Jieyu tour. Cyproheptadine, observe the curative effect of [J]. Clinical Journal of Pediatrics, cytoplasmic two choline in treatment of children with hoarseness cycle comprehensive 2008, 20 (10):847-849.