耳蜗植入后电极兴奋区域的空间分布特征

耳蜗植入后电极兴奋区域的空间分布特征 2003???G1&??G1?p ???????? ?Y?,?l/??e?P?????}&w????????78?3???? ???G?H??????????/”/???\p?? ???-???k&k???Y?k????/??W???’??(&,/?100853) ????:????/????Y?,?l/????(?,???1?P???G???????}&w????78?3?????c???c??????7f?d???}??\??G????7????? ?????}??F0??????20\??l??/?NucleusC124?????(???>????&??????}(NRT)F0????????????????7X?h/?????&? ????/l???p???dF0???8?!?e/n/H?:??(???q?:??/e???}?:??)??7??h/l?c???P??/N?c7B&??}???1?P???P?G?????}?d ??????78?3????F0????1???(?P?G?????}?d??&w???c???@7w???w??????7??c&???;2?1??&??P???????}??????/? /?&??c????????I’ll/n??????:I??/w????,II??/w/l????????(????\????} ?d?D);3???(?G5,10,15&??P???????} ???????k\&?????c&?78/wA,B,C/:???c??/e?Y?}???u???????????????dF0?????P???????}&w??????/e?Y?,?P&? ?????3?C????&678?????c????/w??/???&???a”????????’oA,B,C/:??????78?3?????c/e???u?????:/??????????d?c ???w???????}?d&w????????78?3&???\?/w???}?G????????????\???F0 ???g??:?Y?,?l/????????}?d f”1bA Spatialpatternofneuralexcitationmeasuredonelectrodebandofcochlearimplant XIXinHONGMengdiJIFeiRANDongyiYANGWeiyan DepartmentOtorhinolaryagologychiaesePIAGeneralHospiral100853BeijingChina [Abstract)Objective:Tofindanobjectiveandnon/?invadingmethodtoevaluatethefunctionofsurvivalauditorynerve fibersbymeasuringthespatialneuralexcitationpatternproducedbyeachbandoftheelectrodearmyincochlearimplant recipients.Method:NeuralResponseTelemetry(NRT)softwarewasappliedtorecordtheelectricalevokedcompound actionpotential(ECAP)in20recipients.Thissoftwareimplementsanartifactsubtractiontechniquethatrequirespre- sentationoftwobiphssiccurrentpulses.Thepurposeofmaskeristodrivethenerveintoarefractorystate.Rmaskerpulse andprobepulsearegiventodifferentelectrodesthroughthecochleaneuralexcitationpatternsofeachelectrodecanbe gotten.Results:Allelectrodesshowedoneofbothtwoexcitationpatterns:typ eIhasBell/?shapecurve,typeRhasa shallowslopeofthecurveatthehigh/?frequencyside.Thepatternbecomesbroaderwiththeincreaseofcurrentstimuli intensity.Theneuralexcitationpatternsproducedbyelectrodesthroughoutthecochleaobviouslyoverlap.Thefeaturesof spatialdistributionofexcitationpatternrecorded??the5th,10th,15thelectrodecanbeclassifiedasA.B.C.category Thereisobviousrelationbetweenthecategoryofneuralinteractionandthedurationofprofoundhearingloss.Conclusion: Thespatialneuralexcitationpatterns,whicharecomposedbyagroupoffilters,areverysimilartothetuningcurveof auditoryneuralactivitywithinthecochlea.Therelationbetweenspatialpatternsanddurationofhearinglosssuggeststhat neuralexcitationspatialpatternsallowsomedeductionsaboutthepercentageofneuralsurvival Keywords:cochlearimplantaA/?excitation ?J7~?’?J/M??/????Y?,?l/????!??Z????? ?}?c?J?Y??&k?)???G7???????????????/?/H???? 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R... +A/?.k D??7w???-?d???0?? /H?)/}??F0???hCI24M???P???????(12?l?c?l/? ?????d?????c?c?]?h1??/?/N;CI24Contour?J?P ???????(8?l.?l???????]?hI??&L/?/NF0???u 78??/w:??(--1??)F2/M(-<5???c--1??)F2??(FI 5??)/:??F0 1.2????&??????}NRT???J&?N-1990?????? Iowa?d?????t??/????Y?,?l/??(???>/?ECAP?? ?}??[3]???e???d7X/?Cochlea?c??&?/e????/’?d?? ?)\??;7j/???/?Nucleus24??/????Y?,?1???P?? ECAP??????????&??????}(NRT)???J?c?:?????J &??8??F2&???\A&’Fc?caB?U?c???:?d???????&F0???v?? ???J?J7X?h????????7?\??P\~???:/l???p?????d ?c??????????/?/H????????F0 NRT/??P????7,/M??/?/????P??\?/w7w???P ???c??/W??1.5mm?3???????P??\?/w?????P??F0 ???????P??&????l?)7?\??P\~(ECAAP)?J/?/H???? \s?p&????c?P7w??\H?????d/??????G?????????? ECAP?c?C/w???????J??/k??????F0????1&???1 ?@?w?c???????????h???}?:??/e???q?:???????? ???)(A;B;C;D)F2????7F?.?V?@???}7w??\H?? 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ChineseJoumalOfOtologyVol.1No.12003 \?/???????????F0 3.2???}&w????????78?3?????c??/w?4/???/??? ???}?????G?????????2?c??\?/????????}??F0 ?:??/??G??&????????c?p???????d?}???(?? ??&??????c?????G???????????4F0????78?????? ?????w?c???u???T?!??A??78?3(?1?P???]/wI ??);???u???T?!??C??78?3(?1?P???]/wII??)F0 ?D???c???}&w?????????????c\E//&?/?\?/w???} ?????G??????????\???F0??7O?J???v/?&?7????? ?3?C????/????!????a”\/??\????TF2????\??? ??ab???????c/eII??????&678??\E?c??&???/??? /H????F0 ??/H??????/w?)?8???????J:?????G?????? ???????????4???c???q?:??&???\????@?Z???G?? ???????1/?/l???p?c???}?P??&????h???:?Z??&w ??????&????P\~?c????/w????(I??);?????G???? ?????????????o???c???q?:??\??h??&w?????d?c ?o???~&???/H?Y?,F0?D/?/????Y?,?P????7,???? /N??&????c?,?’(\/??\?)??78???P???????,???? ???c?,????78???P???????,???l??[131F0?@/??,?? ?????}?d/l&??,?’?c?P???????}&w??/w/l???????? (11??)F0 B,C??78?3??????a”?????,?????P????/?I??F2 ?????,?’???P????/?11??ab???????c/??J?2????Z] ??F0?D??&?/?????:???}&w??78?3????/e?Y?}???u ?:?????d?c&?/?????\?/w??/??Y?,?????G????7??? ???5??F0C??78?3?d??&????}?Y?,???:?????????? ?G??????????/e7???F0 /????Y?,??&????c?????4/???/????????P?G?? ???G?h?c?.???P?????????c/H?d&’?F??/????(???? \??G????7????c??&???/H?d&’???????’?2????F0?? ?h????&??????}???J???????P?????}&w???????c?J /?????????/????(?????G??????7??????????c???? ?}???(?l/??e???!???:???d??&??3/?ZEF0 &??3???g 1.????7o?c???}7XF0????/M?Y?,?l/??J??????/M&/?Y ?k???????V??,1998,33:123/?5. 2.HallR.D.Estimationofsurvivingspiralganglioncellsinthe deafratusingtheelectricallyevokedauditoryhminstemresponse. HearingResearch,1990,45:155/?168. 3.BrownC.J.,AbbasP.J.,BorlandJ.etal.Electricalevoked wholenerveactionpotentialinIneraidcochlearit,??antusers.Re, .pan...todifferentstimulatingelectrodeconfigurationsandcomparison topsychophysicalresponses.JournalofSpeechandHearingResearch, 1996,39:453/?467- 4.AbbasP.J.,BrownC.J.,ShallopJ.K.etal.Summaryofre sultsusingtheNucleusCI24Mimplanttorecordtheelectricallyevoked compoundactionpotential.EarandHearing,1999,20:45/?59. 5.?!???(?c?????c?????4&????.&???????&??????}?????? ?? ???G7???&??????????V???c2002,10:67/?69. 6.I,-??Channelinteractionswithdifferentelectrodearray.: resultsfromanimalstudiesandpsychophysinaandrelationtopossible damage.2001Conferenceonimplantablehearingprostheses,Asilomm, California,USA 7.CohenL,SaundersE,ClarkG.Psychophysicsofsprototype peri/?modiolarc,,blewimplantelectrodea&???/?HearingResearch, 2001,155:63/?81. 8.CohenLT,0’LearySJ,KnightMR,:aal.Modelingmethods tailoredtohumanpsychophysicalandECAPdata:practicalapplications tosoundprocessing.2001Conferenceonimplantablehearingprosthe- ?ceg?c/?silomar,California,USA 9.ZwickerE,FastlH.Psychoacoustics/?FactsandModels, Springer,Berlin,1990. 10.ZwickerA,FlottorpG,St-ensS.Criticalbandwidthin loudnesssummation.JournalofAcousticalSocietyofAmerica1957, 29:548/?557. 11???)????/}??:/????Y?,??&???????1999,51:40- 43. 12.??/}???G???p&?????7O???????w7j/N?????????????!?- 1999 13.CohenESL,AschendorffA,ShapiroW,etal.11ueshold, comfortablelevelandimpedancechangesasafunctionofelectrode- m-’,distance.Ear&Hearine.2002.23:28/?40 /??? ?D??\p??F2???@?w/k?’??FN?W????7?&??????’ ??Fu/?/??c???D/??4??&k???!?-???!F0 ?G/?/????h??&??c???)\??(/F?????????????c ????/???/??Y?k????/??W???’??/M???W????7?&? ?????’????7??8???????<??\?????F0&(????7??? ???c?W?????V?t??7???&?/MF2???Y?}?J??????7??c ?????’?????5??&??}?J?????c/M?Y?-????7?&????O ?’???????c7~????7?&??X?????????c?????’?????? ??7??c??????7??c?W?????????h??7??UF0????/F???? ???c?J/?/??Y?k????/??W???’??/W??????????\??( ?????5????F0 ???M?(??/e???@?w???? ?P??:(010)66936752 ?F?@:&,/??l????28&?301&k???Y?;?@?? ?’:100853