仲景胃灵胶囊镇痛抗炎抑制胃肠蠕动作用研究

仲景胃灵胶囊镇痛抗炎抑制胃肠蠕动作用研究 仲景胃灵胶囊镇痛抗炎抑制胃肠蠕动作用 研究 2004??5?6?I?r??May2004 ?L26???L5?3ChineseTraditionalPatentMedicineV01?s26No?s5 ???????????????????????v?????P?????j?l?? ???j???n?I?W???n???????n???????n?????? (?????I?F???Z?????a???l???n????510405) ???O???(?????????????)?????)?????)???v?????P???)?T?E?)?Z?E ?????(?????(?l??????????????(?0???n???<?n?????n?D???n?1????)?????n?????n???v?????P?????jz0?????(???j?????B?????n ?????B?????????n???????T?E?????????7???(?T?Z?n???U?????T?E?J???????n???Z?E???4??????????????????????????z0 ?????(???s???????????????????B?????n?????B???????????C?9???????????jz0?????????T?E?????????7???(?T?Z?n?? ?U?????T?E?J???????n?Z?E???4?????????C?9???????????jz0???C?s?9?????v?????P?????jz0?????(?????????????C?9 ?????????n?????????v?????P?????jz0 ?I???a?????(R2856???O?y???2?(A?????c???(1001El1528(2004)04El0408?s03 Effectofabirritation?nanti??inflammationandgastrointestinalperistalsisinhibi- tionofZhongjingweilingCapsules YEMuElrong?nTANYongElheng?nLIAOXueElzhen?nLIAOHuiElfang?nZHOUJiuElyao (Dept?cPharmacology?nGuangzhouUniversityofTCM?nGuangzhou510405?nChina) KEYWORDS?(ZhongjingweilingCapsule?)analgesia?)antiElinflammation?)gastrointestinalperistalsisinhibition?) mouse?)rat ABSTRACT?(AIM?(TostudytheeffectsofZhongjingweilingCapsule(FructusAmoral?nCortexCinnamemi?n RhizomaAlpiniaeGalangae?nFructusFoeniculi?nRadixGlycyrrhizae?netc?s)onanalgesia?nantiElinflammationand gastrointestinalperistalsisinhibition?sMETHODS?(Theeffectofanalgesiawastestedbythemethodofwrithes andhotElplateonmice?sTheeffectofantiElinflammationwastestedbyinjectingaceticacidandimplantingcotton pelletandxyleneintomice?sRESULT?(Zhon??ingweilingCapsuleeffectivelyinhibitedtheswellingofmousepinEl nainducedbyxyleneandtheincreaseofperitonealcapillarypermeabilitycausedbytheaceticacidinjectedinto mice?sThecapsuleaimdecreasedtheproliferationofgranulomacausedbyimplantationcottonpelletsig nificantly andhadanabirritanteffectonthealgesiainducedbyaceticacidandhotElp[ate?sBesides?niteffectivelyi nhibited thegastrointestinalperistalsis?sCONCLUSION?(Zhon??ingweilingCapsuleisaneffectivemedicine inantiElinflamEl mation?nanalgesia?nandgastrointestinalperistalsisinhibition?s ?????????????X?j???<???7?h?S?v?n?r?????? ??z0?H?0??z2???<z2????z2?D??z2?1???????rz0???C?a ?l????z2???9z2????z2??????????z0l?D???F???j???? ?1??z2?p?Z?????n?????Z?????n?s?w?Z?????n?????]?? ?y????????z0???????s?????????????C?9???????? ???????j??Jz0?S?????F???????n?d???j?????????? ???????????????n?????n???v?????P???????j?????l ???n???a???????????i?( 1???? 1?s1?????s???< ?????????????(?H???J?I???v????????z0?U?z ?????(???R?T???v????????z0??????z2?b?c???????( ???B???R?2?v?????(?????????v????????z0 1?s2???????? SD?Z???E?n???e???j?n?????B150??2009?sNIH ?T?E?n???e???j?n?????B18??229?n?????????n?????B 1?s5--2?s0kg?n???I?????R?2???3???????Bz0 2???? 2?s1???????j 2?s1?s1???T?E?????????????????????T?E60 ?v?k???3?(2003El06El16 ???M?????(ot-aV?(??(1952??)?s?n?K?n???R???n???????n???????a???????n?I?????az2?I?????a ???l??z0?G???(020El36585744z0 408 2004??5?6?I?r??May2004 ?L26???L5?3ChineseTraditionalPatentMedicineV01?s26No?s5 ???n(?????????W???6???f?????x?j30s???B?6?x?T ?E)?n???B?a?B5???n?C20mL??kgz0ig?????n1?f?Td?n ????7d?n?Y?f?????s????30min?C?T?E??????L2J?? ?????6?xz0 2?s1?s2???????7???T?E?????????????????T?E 60???n???e?5???n???B?a?B5???n?C20mL??kgz01ig ?????n1?f?Td?n????7d?n?Y?f?????slh?C?T?E???? ??zr3]ip?????????????n?????5???5?E???????????? ????z0 2?s2???????j 2?s2?s1?????????T?E?????????7???(?T?Z?????? ???T?E50???n???e?5???n???B?a?B5???n?C20mL?? k91ig?????n1?f?Td?n????7d?n?Y?f?????s1h?C?? ???P????????????L4J?????h???8???V?????n?j722 ?a?????????????n??OD?x???Bz0 2?s2?s2?????U???????T?E?J???????????????T ?E50???n???e?5???n???B?a?B5???n?C20mL-kgz01ig ?????n1?f?Td?n????7d?n?Y?f?????s1h?C?T?E?J???? ????bJ?????T?E?J???????n15min?s?5???????n?j?? ?????a?T?E??z2???J?????n???????J???????????B?? ???y?yz0 2?s2?s3???Z?E???4???????????????Z?E50???n ???e?5???n???B?a?B5???n?5???5?E???C?Z?E???4?e ????bAJ???i???????4?n?f??????ig?????n1?f?Td?n?? ??7d?n?Y?f?????s12h???????4?????????n?9???? ????24h?s????z0 2?s3???????????????? 2?s3?s1???T?E?T???????????????????T?E60 ???n???B?a?B5???n?C20mL??kg??ig?????n1?f?Td?n ????7d?n?Y?f?????s1h?C???Y??????????[7]???e ?Y10?M???Y??5?M?k???X????????0?s2mL??109z01 ?????n?????s15min?5???????n?????????????n?C?? ?Y???????????????????????Y???????a??z0 2?s3?s2???????????????????????????????n???? 2cm?n??TyrodeENS???V???????????s???0?j?????? (????????TyrodeENs???????B20mL)?n?j???????? ??????(OC??100??)???????????F?????????v?w?? ??z0 3???????? ?????x?jj?n??S???B?n?j?r????????????t?? ?????????????5?az0 4???? 4?s1???????j 4?s1?s1???T?E???????????????? ??????????????z2?Iz2??3?u?<?????????????? ???????6?x?????9??????P<0?s05z0????????1z0 Tab?s1Anelegsiaeffectofthepaininduced byhot??plate inmicen?(12(j??sJ ?<?????s???6???x(s) ??(g”kg-t[)??30m?Cin??????60m??in??????90min?????D20ml3?s64??2?s166?s82??4?s475?s82 ??2?s79 ????????????2?s8810?s91??3?s59E812?s00??4?s752EN16?s82??7?s252EN ????????????1?s4410?s19??3?s03E812?s18??595??16?s86??6?s382EN ????????????0?s7216?s09??5?s35E822?s82??4?s532EN21?s18??10792) ??????0?s0312?s82??5?s042EN15?s91??6?s38”20?s64??7?s092EN Note?(Comparewihecontrolgroup?(1)P<0?s05?)2)P<0?sOl(?i ?n) 4?s1?s2???????7???T?E?????????????? ??????????????z2?I?<???????9???????????? ?7???T?E????????????????P<0?s05z0???????? 2z0 Tab?s2Effectofzhongjingweilingcapsuleonturningbody induced byaceticacidinmice?sn?(12(j??s) 4?s2???????j 4?s2?s1?????????T?E?????????7???(?T?Z?????? ??????????????z2?Iz2??3?u?<???????????T?E ?????????7???(?T?Z???C?9???Z???v???jP< 0?s01z0????????3z0 Tab?s3Effectofzhongjingweilingcapsuleonperitoneal capillarypermeabilityby aceticacidinducedinmice?s(X??S) 4?s2?s2?????U???????T?E?J???????????? ??????????????z2?I?<?????????U???????T?E ?J???????C?9???Z???v???jP<0?s05z0???????? 4z0 Tab?s4Effeetof zhon??ingweilingcapsuleonpinnaswelling inducedbyxyleneinmice?s(?9??sJ 2004??5?6 ?L26???L5?3 ?I?r?? ChineseTraditionalPatentMedicine May2004 V01?s26NO?s5 4?s2?s3???Z?E???4???????????? ??????????????z2?Iz2??3?u?<???????Z?E???4 ?????????C?9???Z???v???jP<0?s05z0???????? 5z0 Tab?s5Effectof zhongjingweilingcapsule on weight of granulomainratinducedbycottonpettet?s(j??S) 4?s3???????????????? 4?s3?s1???T?E?T???????????????? ??????????????z2?Iz2??3?u?<?????????9???? ?v?T?E?T??????????????P<0?s01z0????????6z0 Tab?s6Effectsofzhongjingweilingcapsuleonmice intestinalfunction(j??s) 4?s3?s2?????????????????????? ??????????????z2?Iz2??3?u?<???????????? Ach(????1?(10000Ach0?s5mL)?P?????????????F ?????????v?w?????????n?n???v?w?????????9??P <0?s01z0????????7z0 5???? ?h?????????????s?(???????????????9?????? Tab?s7Effectsofzhongjingweilingcapsuleonrabbits intestinalfunctionn?(12lX??s) ?????????????????6?x?)?????????????7???T?E?? ???????????????n???C??????????????z0???????7 ???T?E?????????7???(?T?Z???????????U???????T ?E?J?????????C?s?9???v???j?)???Z?E?????????? ???????s???s?9???v???4???????????3z0???s???? ?p?Z?????Z???????C?9???????v???jz0?n???n???? ???????????????v?T?E?T?????Y?????????n?????? ???HAch?P?????????????F?????????v?w?????? ??z0???C?????????????jz0?????n?L?????B?????? ??????????????z2??????????????z2???????P?????h ????????z2?????s???r?????????????????a??????z0 ???4???O [1]???j???n???r?n???????n???s???????????????????????j?l?? [J]?s?I?r???n2002?)24(9)?(692El694 [2?n3?n5El7]???????s?I?????a??????????[M]?s?h???(?h???????? ?X?????9?s?L?????s?h???st991?s350?n353?n300?n304?n320?s [4]?????s?I?????a????[M]?s?V???(???d???3?????9z01993?s86?s ?I?????X?3?h???6?P??????????(2003)???4?( ?S??zh?I?????X?3?h???6??????????(CAJCED2003)))5480???????h??120???y???I???????P?j?? ?4?? ?O??ER?I???3?h??E8?I??????2002???????i?????????????n???????6?????a???nzh?I?r??)2003?? ?????O???? ?y?y??Web?i???????????i?( ?F???P???f???????????P??2002??????web?i???? 22140?s62900?s92233936108 410