细胞膜表面的分化抗原CD分类

CD（Cluster of differentiation）就是细胞膜表面的分化抗原群/分化抗原簇，应用聚类分析，可将来自不同识别同一分化抗原的单克隆抗体归为一个CD，经由从1982年第1次国际上人类白细胞分化抗原会议（The Human Leucocyte Differentiation Antigen workshop，HLDA） 统一命名。迄今为至，人CD的序号已从CD1命名至CD350 (2009年)，可大致划分为T细胞、B细胞、髓细胞、NK细胞、血小板、粘附分子、内皮细胞、细胞因子受体、激活抗原、碳水化合物半抗原、树突状细胞、干细胞／祖细胞、基质细胞和红细胞14个组。白细胞分化抗原（Leucocyte Differentiation Antigen，LDA）是指不同谱系(1ineage)血细胞在正常分化，成熟，活化过程中出现或消失的细胞表面标志，多是跨膜蛋白或糖蛋白，少数为碳水化合物半抗原。随着人类功能基因组计划研究以及免疫学与其他学科的交叉，人类白细胞分化抗原的概念逐渐被人类细胞分化分子(HCDM)所替代。郑州大学一附院内科血液病万鼎铭     采用单克隆抗体鉴定方法识别的白细胞分化抗原又称CD （cluster of differentiation） 抗原。 检测CD 抗原是实验室识别细胞及不同分化阶段细胞或细胞亚群最主要的方法。白细胞分化抗原（狭义上的CD）参与机体重要的生理和病理过程：①免疫应答过程中免疫细胞的相互识别，免疫细胞抗原识别、活化、增殖和分化，免疫效应功能的发挥；②造血细胞的分化和造血过程的调控；③参与炎症反应、血栓形成和组织修复；④参与细胞的生长、分化、迁移，及肿瘤的恶化和转移。     CD在基础免疫学研究中主要应用于：①CD抗原的基因克隆，新CD抗原及新配体的发现；②CD抗原结构与功能关系；③细胞激活途径和膜信号的传导；④细胞分化过程中的调控；⑤细胞亚群的功能。CD在临床免疫学研究中主要用于：①机体免疫功能的检测；②白血病、淋巴瘤免疫分型；③免疫毒素用于肿瘤治疗、骨髓移植以及移植排斥反应的防治；④体内免疫调节治疗。     在许多场合下，抗体及其识别的相应抗原都用同一个CD序号，因此在参阅教科书和文献时需加注意：(1)CD是流水编号，CD129暂缺；CD67和CD66b是重复的；CD187-190，CD211，CD237，CD341-343，CD345-248暂未编号。(2)CD中带有w的抗原或抗体CDw12，CDw198，CDw199，CDw293尚需继续进行全面鉴定。(3)有些CD抗原又可进一步划分为不同的成员，一般用小写英文字母表示，但情况有所不同：①如CD1可分为CD1a，CD1b和CD1c，这三种不同分子是分别由三个不同的高度同源的基因所编码；②CD45至少可分为CD45RA，CD45RB，CD45RC和CD45RO，它们是同一基因的不同异型/同种型（isoform）；③CD2和CD2R是识别同一个分子上不同的表位；④CD49已进一步划分为CD49a，D49b，CD49c，CD49d，CD49e和CD49f，它们的基因定位于不同的染色体上，但具有较高的同源性。（4）CD的组划分的特异性是相对的，实际上，许多CD抗原的组织细胞分布较为广泛。此外，有的CD抗原可由不同的分类角度而归入不同的组，如IL-2受体a链CD25是活化T细胞的标记，也属于细胞因子受体；再如某些属于T细胞、B细胞、髓细胞或NK细胞组的CD抗原实际上也是粘附分子，等等。 CD  主要抗原表达(Main Antigen Expression)/其他名字/分子量(kDa) CD1a Cortical Thymocytes (stg), B cell subset, Dendritic cells, Langerhans cells 49,12 CD1b Cortical Thymocytes (mod), B cell subset, Dendritic cells, Langerhans cells 45,12 CD1c Cortical Thymocytes (weak), B cell subset, Dendritic cells, Langerhans cells 43,12 CD2  T cells, NK cells LFA-2, E-Rosette Receptor 50 CD2R Activated T cells 50 CD3 T cells 16,20,25-28 CD4 Helper-inducer T cells, Monocytes, Macrophages 56 CD5 T cells, B cell subset 67 CD6 T cells, B cell subset 105 CD7 T cells 40 CD8 Cytotoxic/Suppressor T cells, NK cells 32-34 CD9 Platelets, Monocytes, Pre-B cells 24 CD10 Pre-B cells, Granulocytes CALLA 100 CD11a Leukocytes LFA-1, αL Integrin 180 CD11b Granulocytes, Monocytes, NK cells MAC-1, αM Integrin, CR3 170 CD11c Granulocytes, Monocytes, NK cells, T cell subset, B cell subset, αX Integrin 150 CDw12 Granulocytes, Monocytes 90-120 CD13 Granulocytes, Monocytes Aminopeptidase N 130 CD14 Monocytes 55 CD15 Granulocytes, Monocytes Lewis X CHO CD15s Neutrophils Sialyl Lewis X CHO CD15u Myeloid subset Sulfated Lewis X CHO CD16a NK cells, Macrophages FcRIII A 50-65 CD16b Granulocytes FcRIII B 48 CD17 Granulocytes, Monocytes, Platelets Lactosylceramide - CD18 Leukocytes (Platelets negative) β2 Integrin 95 CD19 B cells 90 CD20 B cells 33,35,37 CD21 B cells subset, Follicular dendritic cells CR2 145 CD22 B cells 140 CD23 B cell subset, Eosinophils, Platelets FcεRII 50-45 CD24 B cells, Granulocytes 41/38 CD25 Activated T cells IL-2Rα Chain 55 CD26 T cell subset, Macrophages 110 CD27 T cell subset 55 CD28 T cell subset 44 CD29 Leukocytes β1 Integrin 130 CD30 Activated T and B cells, Reed Sternberg cells Ki-1 105 CD31 Platelets, Monocytes, Granulocytes, B cells PECAM-1, GPIIa 140 CD32 Monocytes, Neutrophils, B cells, Eosinophils FcRII 40 CD33 Myeloid Progenitor cells, Monocytes 67 CD34 Hematopoietic Progenitor cells 105-120 CD35 Monocytes, B cells, Granulocytes CR1 160,190,220,250 CD36 Monocytes, Platelets GPIV (IIIb) 88 CD37 B cells 52-40 CD38 Activated T cells, Plasma cells 45 CD39 B cells, Monocytes 100-70 CD40 B cells, Monocytes, Carcinoma cells 48/44 CD41 Platelets, Megakaryocytes GPIIb/IIIa, αIIb Integrin 120 CD42a Platelets, Megakaryocytes GPIX 23 CD42b Platelets, Megakaryocytes GPIB-a 135,23 CD42c Platelets, Megakaryocytes GPIB-b 22 CD42d Platelets, Megakaryocytes GPV 85 CD43 T cells, Granulocytes, Monocytes   Leukosialin 90-100 CD44 Leukocytes, Erythrocytes H-CAM, Pgp-1 8-90 CD44R (Varied-dependent upon Exon Splicing) CD45 Leukocytes Leukocyte Common Antigen 180,190,205,220 CD45RA B cells, T cell subset, Monocytes 220,205 CD45RB B cells, T cell subset, Monocytes 190,205,220 CD45RC B cells, T cell subset 190,205,220 CD45RO B cells, T cell subset, Monocytes 180 CD46 Ubiquitous (Erythrocytes negative) Membrane Cofactor Protein 66,56 CD47 Ubiquitous 47-52 CD47R Broad 47-52 CD48 Leukocytes 43 CD49a Activated T cells VLA-1, α1 Integrin 210 CD49b B cells, Monocytes, Platelets VLA-2, α2 Integrin 160 CD49c B cells VLA-3, α3 Integrin 125 CD49d Lymphocytes, Monocytes, Eosinophils VLA-4, α4 Integrin 150,80,70 CD49e T cell subset, Monocytes, Platelets VLA-5, α5 Integrin 132/25 CD49f T cell subset, Monocytes VLA-6, α6 Integrin 120/25 CD50 Leukocytes ICAM-3 124 CD51 Platelets αV Integrin 125/25 CD51/61 Platelets, Osteoclasts, Endothelial cells complex CD52 Leukocytes CAMPATH-1 21-28 CD53 Leukocytes 32-40 CD54 Endothelial cells, Various activated cells ICAM-1 90 CD55 Broad Decay Accelerating Factor 75 CD56 NK cells N-CAM 220/135 CD57 NK cells, T cell subset HNK-1 110 CD58 Broad LFA-3 65-70 CD59 Broad   Protectin, Homologous Restriction Factor 18-20 CD60a T cell subset, platelets GD3   CHO CD60b T cell subset, activated B cells 9-0-sialyl GD3   CHO CD60c T cell subset 7-0-sialyl GD3   CHO CD61 Platelets, Megakaryocytes β3 Integrin, GPIIIa 110 CD62E Endothelial cells E-Selectin, ELAM-1 140 CD62L Lymphocytes, Monocytes, NK cells L-Selectin, LECAM-1 150 CD62P Activated Platelets, Endothelial cells P-Selectin, LECAM-3 75-80 CD63 Activated Platelets, Monocytes 53 CD64 Monocytes FcRI 75 CD65 Neutrophils CD65s Neutrophils, Monocytes CD66a Neutrophils Biliary Glycoprotein 160-180 CD66b Granulocytes CGM6 95-100 CD66c Neutrophils, Colon carcinoma NCA 90 CD66d Neutrophils CGM1 30 CD66e Colon epithelial CEA 180-200 CD66f Pregnancy Specific Glycoprotein CD67 (Re-assigned to CD66b) (重复CD66b) CD68 Monocytes, Macrophages 110 CD69 Activated T and B cells, NK cells Activation Inducer Molecule 34/28 CD70 Activated T and B cells, Reed-Sternberg cells 75,95,170 CD71 Proliferating cells Transferrin Receptor 95 CD72 B cells 43/39 CD73 B & T cell subset ECTO-5' Nucleotidase 69 CD74 B cells, Monocytes Invariant Chain 41,35,33 CD75 B cell subset, Epithelial Lactosamines CHO CD75s B cell subset α-2, 6-sialylated Lactosamines CHO CD77 Activated B cells, Endothelial cells CD79a B cells MB-1 33,40 CD79b B cells B29 33,40 CD80 Activated B cells B7-1 60 CD81 B cells, T cells, Neutrophils TAPA-1 22 CD82 Leukocytes, Platelets 50-53 CD83 Dendritic cells, Activated lymphocytes HB15 43 CD84 Monocytes, Platelets, B cells 73 CD85 Dendritic cells, Monocytes, B cells see note 1 in notes section 110 CD86 Monocytes, Activated B cells B7-2 80 CD87 Granulocytes, Monocytes, Activated T cells UPA Receptor 50-65 CD88 Granulocytes C5a Receptor 42 CD89 Neutrophils, Monocytes Fcα Receptor 55-70 CD90 Progenitor cell subset, Thymic Stromal cells THY-1 18 CD91 Monocytes α2 Macroglobulin Receptor 600 CD92 Neutrophils, Monocytes, Platelets, Endothelial cells 70 CD93 Neutrophils, Monocytes, Endothelial cells 120 CD94 NK cells, T cell subset 30 CD95 Apoptotic cells FAS 42 CD96 Activated T cells Tactile 160 CD97 Activated T cells CD55 Ligand 74,80,89 CD98 Monocytes, T cells, B cells 4F2 80,40 CD99 Lymphocytes, Thymocytes 32 CD99R T cells, NK cells, Myeloid cells 32 CD100 Broad 150 CD101 Granulocytes, Monocytes, Activated T cells 140 CD102 Lymphocytes, Monocytes ICAM-2 60 CD103 Intra Epithelial Lymphocytes HML-1, αE Integrin 150,25 CD104 Epithelial, Schwann cells β4 Integrin 220 CD105 Endothelial cells Endoglin 95 CD106 Activated Endothelial cells VCAM-1 100-110 CD107a Activated Platelets LAMP-1 110 CD107b Activated Platelets LAMP-2 120 CD108 Activated splenic T cells 80 CD109 Activated T cells, Platelets, Endothelial cells Platelet Activation Factor 170/150 CD110Stem cell subset,Megakaryocytes,Platelets (v. weak) Thrombopoietin Receptor, Mpl 82-84 CD111 Stem cell subset, Macrophages, Neutrophils PRR/Nectin-1 64-72 CD112 Monocytes, Neutrophils, Stem cell subset PRR2/Nectin-2 64-72 CD113 Epithelial cells, Placenta PRR3, Nectin-3 83 CD114 Granulocytes, Monocytes G-CSF Receptor 95,139 CD115 Monocytes, Macrophages M-CSF Receptor 150 CD116 Monocytes, Neutrophils, Eosinophils GM-CSF Receptor αChain 60 CD117 Progenitor cells SCF-Receptor, c-kit 145 CD118 Epithelial cells LIF Receptor 190 CD119 Monocytes, B cells, Epithelial cells IFN γ Receptor 90 CD120a Monocytes, Granulocytes TNF Receptor, Type 1 55 CD120b Monocytes, Granulocytes, TNF Receptor, Type 2 75 Activated lymphocytes CD121a T cells, Fibroblasts, Endothelial cells IL-1 Receptor, Type 1 80 CD121b B cells, Monocytes, Macrophages IL-1 Receptor, Type 2 68 CD122 T cell subset, NK cells IL-2 Receptor β Chain 75 CD123 Progenitor cells, Granulocytes, Monocytes, Megakaryocytes, IL-3 Receptor α Chain 70 CD124 B cells, T cells, Progenitor cells IL-4/IL-13 Receptor 140 CD125 Eosinophils, Basophils IL-5 Receptor α Chain 60 CD126 Plasma cells, Activated B cells IL-6 Receptor α Chain 80 CD127 Early B cells, T cells, Progenitor cells, Monocytes, IL-7 Receptor α Chain 65-75 CD129 Not assigned CD130 Plasma cells, Activated B cells   gp130Receptor Subunit for IL-6,IL-11,LIF, OSM, LNTF,CT-1             130 CD131 Myeloid cells Common β Chain for IL-3, IL-5, GM-CSF Receptor  120 CD132 Broad  Common γ Chain for IL-2, IL-4, IL-7, IL-9, IL-15 Receptors  64 CD133 Stem cell subset AC-133 120 CD134 Activated T cell subset OX40 48-50 CD135 Progenitor cell subset Flt3/FIk2 130-150 CD136 Epithelial cells Macrophage Stimulating Protein Receptor 180 CD137 T cell subset 4-1BB 30 CD138 Plasma cells, Epithelial cells SYNDECAN-1 20 CD139 Germinal center B cells 209,228 CD140a (Undetectable on most normal cells) PDGF Receptor α 180 CD140b Endothelial cell subset, Stromal cells PDGF Receptor β 180 CD141 Endothelial cells Thrombomodulin 100 CD142 Activated Monocytes and Endothelial cells Tissue Factor 45 CD143 Endothelial cell subset Angiotensin Converting Enzyme 170 CD144 Endothelial cells VE-CADHERIN 135 CDw145 Endothelial cells, Some stromal cells 25,90,110 CD146 Endothelial cells, Activated T cells MUC18/S-endo 118 CD147 Endothelial cells, Monocytes, T cell subset, Platelets, Erythrocytes,  Neurothelin/Basigin  50-60 CD148 Hematopoietic cells HPTP-ETA/DEP-1 CD150 T cell subset, B cell subset, Thymocytes SLAM 70 CD151 Platelets, Endothelial cells PETA-3 27 CD152 Activated T cells CTLA-4 44 CD153 Activated T cells CD30 Ligand 40 CD154 Activated T cells, Mast cells, Basophils CD40 Ligand 33 CD155 Monocytes, Macrophages, Thymocytes Poliovirus Receptor 80-90 CD156a Monocytes, Macrophages, Granulocytes ADAM8 60 CD156b Broad TACE/ADAM17 85 CD156c Broad ADAM-10 98 CD157 Monocytes, Neutrophils, Endothelial cells BST-1 42-45 CD158 T cell subset, NK cell subset see note 2 in notes section CD158a NK cells, T cell subset p58.1, P50.1 50,58 CD158b NK cells, T cell subset p58.2, p50-2 50,58 CD159a NK cells NKG2a 43 CD159c NK cells NKG2C 40 CD160 T cell subset, NK cell subset By55 26 CD161 NK cells, T cell subset NKR-P1 60 CD162 T cells, Monocytes, Granulocytes, B cell subset PSGL-1 110 CD162R NK cell subset PEN5 CHO CD163 Monocytes KiM4 130 CD164 T cells, Monocytes, Granulocytes, B cell subset, Progenitor cells  MGC-24 80 CD165 Thymocytes, Thymic epithelial cells AD2/gp37 37 CD166 Activated Lymphocytes, Endothelial cells, Fibroblasts ALCAM, CD6 Ligand 100 CD167a Epithelial cells, Myoblasts  Discoidin Domain Receptor, DDR1 120 CD168 Thymocyte subset, T cell subset, Monocytes RHAMM 84-88 CD169 Macrophage subset Sialoadhesin 185 CD170 Macrophage subset, Neutrophils Siglec-5 140 CD171 Monocytes, T cell subset, B cells L1 200 CD172a Monocytes, T cell subset, Stem cells SIRP α 110 CD172b Monocytes, Dendritic cells SIRP β1 50 CD172g T cells, Activated NK cells SIRP γ, SIRP β2 45-50 CD173 Red cells, Stem cell subset, Platelets Blood group H type 2 CHO CD174 Stem cell subset, Epithelial cells Lewis Y CHO CD175 Stem cell subset TN CHO CD175s Erythroblasts Sialyl-Tn CHO CD176 Stem cell subset Thomson-Friedrenreich antigen CHO CD177 Neutrophil subset NB1 56-62 CD178 Activated T cells Fas ligand 38-42 CD179a Pro-B cells, Pre-B cells V pre beta 16 CD179b Pro-B cells, Pre-B cells Lambda 5 22 CD180 B cell subset, Monocytes, Dendritic cells Rp105/Bgp 95 95-105 CD181 Neutrophils, T cell subset CXCR1 39 CD182 Monocytes, Granulocytes, T cell subset CXCR2 40 CD183 Activated T cells, Activated NK cells CXCR3 40 CD184 T cell subset, B cells, Monocytes, Dendritic cells, Endothelial cells,  CXCR4  45 CD185 B cells, T cell subset CXCR5 45 CD186 T cell subset CXCR6, BONZO 40 CD191 T cells, Monocytes, Stem cell subset CCR1 39 CD192 Monocytes, T cell subset, B cells, Basophils, Endothelial cells，  CCR2 40 CD193 Eosinophils, Basophils, T cell subset, Dendritic cell subset， CCR3 45 CD194 T cells, Bascphils, Platelets, Monocytes (low) CCR4 41 CD195 Monocytes, T cell subset CCR5 45 CD196 T cell subset, B cells, Dendritic cell subset CCR6 45 CD197 T cell subset CCR7 45 CDw198 T cell subset, Monocytes CCR8 50 CDw199 T cell subset CCR9 50 CD200 Thymocytes, B cells, Endothelium, Activated T cells OX-2 45-50 CD201 Endothelial cell subset Endothelial cell Protein C Receptor(EPCR) 50 CD202b Endothelial cells, Stem cells Tie/Tek 150 CD203c Basophils, Megakaryocytes NPP3 130-150 CD204 Macrophages Macrophage Scavenger Receptor 220 CD205 Dendritic cells, Thymic epithelium DEC-205 205 CD206 Dendritic cell subset, Macrophages, Monocytes Macrophage Mannose Receptor 180 CD207 Immature langerhans cells Langerin 40 CD208 Interdigitating dendritic cells DC-LAMP 70-90 CD209 Dendritic cell subset DC-SIGN 44 CDw210 T cells, B cells, NK cells, Monocytes, Macrophages IL-10R 90-110 CD212 Activated T cells, Activated NK cells IL-12Rβ1 100 CD213a1 B cells, Monocytes, Fibroblasts, Endothelial cells IL-13Rα1 65 CD213a2 B cells, Monocytes IL-13Rα2 65 CD217 Broad IL-17R 120 CD218a Lymphocytes, Neutrophils, Dendritic cell subset IL-18Rα 70 CD218b Lymphocytes, Neutrophils, Dendritic cell subset IL-18Rβ 70 CD220 Broad   Insulin Receptor 140 + 70 CD221 Broad   IGF-1 Receptor 140 + 70 CD222 Broad   IGF-2 Receptor/ Mannose-6-phosphate Receptor 250 CD223 Activated T cells, Activated NK cells LAG-3 70 CD224 Leukocytes, Stem cells Gamma Glutamyl Transferase (GGT) 27, 68 CD225 Broad Leu-13 17 CD226 T cells, NK cells, Monocytes, Platelets DNAM-1 65 CD227 Stem cell subset, Epithelial cells MUC-1 300 CD228 Stem cells, Melanoma cells Melanotransferrin 80-95 CD229 T cells, B cells Ly-9 95, 110 CD230 Broad Prion Protein 35 CD231 T cell leukemia, Neuroblastoma TALLA-1 30-45 CD232 Broad VESPR (Plexin C1) 200 CD233 Red cells Band 3 90 CD234 Red cells Duffy 35-45 CD235a Red cells Glycophorin A 36 CD235b Red cells Glycophorin B 20 CD236 Stem cell subset, Red cells Glycophorin C/D 32/23 CD236R Stem cell subset, Red cells Glycorphorin C 32 CD238 Stem cell subset, Red cells Kell 93 CD239 Stem cell subset, Red cells B-CAM, Lutheran 78-85 CD240CE   Red cells Rhesus 30 CE 30-32 CD240D    Red cells Rhesus 30 D 30-32 CD241 Red cells Rhesus 50 Glycoprotein 50 CD242 Red cells ICAM-4 42 CD243 Stem cells MDR-1 180 CD244 NK cells, T cell subset 2B4 70 CD245 T cell subset p220/240 220-240 CD246 Anaplastic T cell leukemia Anaplastic Lymphoma Kinase 80 CD247 T cells, NK cells TCR zeta chain 16 CD248 Stromal Fibroblasts, Tumor endothelium Endosialin 175 CD249 Endothelial cells, Epithelial cells Aminopeptidase A 160 CD250 Reserved for TNF CD251 Reserved for lymphotoxin CD252 Dendritic cells, Endothelial cells, Activated B cells OX40 Ligand 34 CD253 Activated T cells, Activated B cells, Activated monocytes TRAIL 33-34 CD254 Activated T cells, Stromal cells, Osteoblasts TRANCE, RANKL 35 CD255 Reserved for TWEAK CD256 Myeloid cells APRIL 16 CD257 Myeloid cells BlyS, BAFF 45 CD258 Activated T cells, Immature dendritic cells LIGHT 28 CD259 Reserved for NGF CD260 Reserved for lymphotoxin beta receptor CD261 Leukocytes (very weak), Tumor cells TRAIL-R1, APO2 57 CD262 Broad TRAIL-R2, DR5 60 CD263 Broad (weak) TRAIL-R3, DcR1 65 CD264 Broad TRAIL-R4, DcR2 35 CD265 Broad, Osteoclasts, Dendritic cells RANK, TRANCE-R 97 CD266 HUVEC TWEAK-R 14 CD267 B cells (weak), Activated T cells TACI 32 CD268 B cells, T cells (weak) BAFF-R 25 CD269 B cells BCMA 27 CD270 Reserved for LIGHTR CD271 Neurons, Stromal cells, Follicular dendritic cells NGFR 75 CD272 Th1 cells BTLA CD273 Dendritic cells, Activated T cells, Activated monocytes B7-DC, PD-L2 25 CD274 Dendritic cells, Activated T cells, Activated monocytes B7-H1, PD-L1 40 CD275 Dendritic cells, B cells (weak), T cells (weak), Activated monocytes， ICOSL 60 CD276 Dendritic cell subset, Activated monocytes B7-H3 (long) 40-45 CD277 T cells, B cells, NK cells, Monocytes, Dendritic cells, Stem cell， BT3.1, BTF5 56 CD278 Activated T cells ICOS, AILIM 56 CD279 Activated T cells, Activated B cells PD1 55 CD280 Myeloid progenitors, Fibroblasts, Endothelial cell subset, Macrophage subset，  Endo180, TEM22 180 CD281 Monocytes, Neutrophils TLR1, TIL 90 CD282 Monocytes, Neutrophils TLR2, TIL4 85 CD283 Fibroblasts, Dendritic cells TLR3 100 CD284 Monocytes (weak) TLR4 85 CD285 Reserved for TLR5 CD286 Monocytes, Dendritic cells, Endothelial cells TLR6 92 CD287 Reserved for TLR7 CD288 Peripheral blood leukocytes, Monocytes, Dendritic cells TLR8 120 CD289 Dendritic cell subset, Activated B cells TLR9 115-120 CD290 B lymphocytes, Dendritic cells TLR10 95 CD291 Reserved for TLR11 CD292 Bone progenitor cells BMPR1A 50-58 CDw293 Bone progenitor cells BMPR1B 50-58 CD294 Th2 cells, Eosinophils, Basophils CRTH2, GPR44 55-70 CD295 Broad, Monocytes (weak) LEPR, OBR 130-150 CD296 Epithelial cells, Muscle, T cell subset, Myeloid cell subset ART1 37 CD297 Red cells, Erythroblasts, Activated monocytes ART4, Dombrock Blood Group 38 CD298 Broad Na,K ATPase β3 Subunit 52 CD299 Endothelial cell subset DC-SIGNR, L-SIGN 45 CD300a Dendritic cells, Monocytes, Lymphocyte subsets CMRFH 60 CD300c Dendritic cells, Monocytes, Lymphocyte subsets CMRF35A CD300e Monocytes CMRF35L1 CD301 Immature dendritic cells MGL, CLECSF14 38 CD302 Granulocytes, Monocytes, Dendritic cells DCL1 30 CD303 Dendritic cell subset BDCA2 38 CD304 Dendritic cell subset BDCA4, Neuropilin 140 CD305 NK cells, T cells, B cells, Monocytes LAIR-1 40 CD306 Putative secreted protein LAIR-2 CD307 B cell subset IRTA2, FcRH5 100 CD308 Reserved for VEGFR1 CD309 Endothelial cells, Stem cell subsets VEGFR2, FLK1, KDR 230 CD310 Reserved for VEGFR3 CD311 Reserved for EMR1 CD312 Neutrophils, Monocytes, DC subset, Macrophages, Activated lymphocytes, EMR2 90 CD313 Reserved for EMR3 CD314 NK cells, T cell subset NKG2D 42 CD315 B cell subset, Activated monocytes CD9P1, SMAP6 135 CD316 B cells, T cells, NK cells (weak) EWI2, IgSF8 63 CD317 B cells, T cells, Monocytes, NK cells, Dendritic cells BST2, HM1.24 29-33 CD318 Stem cell subset CDCP1, SIMA135 135 CD319 NK cells, T cell subset, B cell subset, Dendritic cell subset CRACC, SLAMF7 66 CD320 Follicular dendritic cells 8D6 CD321 Broad JAM-1, F-11R 32-35 CD322 Endothelial cells, Monocytes, B cells, T cell subset JAM-2, VE-JAM 45 CD323 Reserved for JAM-3 CD324 Epithelial cells, Stem cells, Erythroblasts E-Cadherin, Cadherin 1 120 CD325 Neurons, Endothelial cells, Stem cells N-Cadherin, Cadherin 2 140 CD326 Epithelial cells   Ep-CAM 40 CD327 B cells, Trophoblasts     Siglec6, OB-BP1 CD328 NK cells, Monocytes, T cell subset   Siglec7, AIRM1 75 CD329 Monocytes, Granulocytes, NK cells   Siglec9 CD330 Reserved for Siglec10 CD331 Fibroblasts, Epithelial cells   FGFR1, FLT2 130 CD332 Fibroblasts, Epithelial cells   FGFR2, KGFR 115-135 CD333 Fibroblasts, Epithelial cells   FGFR3, JTK4 115-135 CD334 Fibroblasts, Epithelial cells   FGFR4, JTK2 110 CD335 NK cells   NKp46, NCR1, Ly94 46 CD336 NK cells   NKp44, NCR2, Ly95 44 CD337 NK cells   NKp30, NCR3, Ly117 30 CD338 Stem cell subset   ABCG2, BCRP 72 CD339 Stromal cells, Epithelial cells,    Jagged1, JAG1 150 CD340 Stem cell subset,    HER-2 185 CD344 Stem cell su