孤束核在艾灸保护胃粘膜损伤中的作用

孤束核在艾灸保护胃粘膜损伤中的作用 SICENCE新闻发布 作者: 彭亮 稿号:NRR_14_14 孤束核在艾灸保护胃粘膜损伤中的作用 目前在灸疗保护胃粘膜机制领域，同类多项研究已证明艾灸对胃粘膜的保护作用确与艾灸上调热休克 蛋白70达有关，然而尚未见到在灸疗保护胃粘膜机制的神经通路相关机制分析的报道。湖南中医 药大学针灸推拿学院彭亮博士所在课题组进行的一项研究证实，艾灸足三里穴(ST36)预处理对胃粘 膜损伤有明显保护作用，孤束核损毁可明显抑制其保护效应，由此推断孤束核是艾灸减轻胃粘膜损伤 的重要中枢神经信息调节部位。作者认为，文章结果对探明艾灸作用神经传导途径有重要的指导意义， 同时对艾灸治病机制的研究提供了重要的理论依据。文章发表在《中国神经再生研究(英文版)》杂志 2014年1月第2期。 苏木精伊红染色显示，大鼠孤束核严重受损，图中切片中箭头所指示核团损坏灶，并有神经传导簇生成，系损害后引 起 Article: " Role of the nucleus tractus solitarii in the protection of pre-moxibustion on gastric mucosal lesions," by Liang Peng, Mi Liu, Xiaorong Chang, Zhou Yang, Shouxiang Yi, Jie Yan, Yan Peng (College of Acupuncture and Tuina, Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, China) Peng L, Liu M, Chang XR, Yang Z, Yi SX, Yan J, Peng Y. Role of the nucleus tractus solitarii in the protection of pre-moxibustion on gastric mucosal lesions. Neural Regen Res. 2014;9(2):198-204. 欲获更多资讯:Neural Regen Res. NTS’s role in the protection of pre-moxibustion on gastric mucosal lesions Moxibustion may have protective effects on the stomach mucous membrane against stress gastric ulcer. The potential mechanism of moxibustion may be mediated by transforming growth factor-α, gastric mucosa cell proliferation, inhibition of apoptosis, and the expression of heat shock protein-70. Previous studies have shown that somatic sensation by acupuncture and visceral nociceptive stimulation can converge in the nucleus tractus solitarii (NTS) where neurons integrate signals impacting on the function of organs. To explore the role of the NTS in the protective mechanism of pre-moxibustion on gastric mucosa, Dr. Liang Peng and co-workers from College of Acupuncture and Tuina, Hunan University of Chinese Medicine in China pointed out that moxibustion pretreatment at the Zusanli point is protective against acute gastric mucosa injury, and NTS damage inhibits these responses. Therefore, the NTS may be an important area for SICENCE新闻发布 作者: 彭亮 稿号:NRR_14_14 regulating the signal transduction of the protective effect of pre-moxibustion on gastric mucosa. The relevant paper has been published in the Neural Regeneration Research (Vol. 9, No. 2, 2014). Nucleus tractus solitarii damage is shown by hematoxylin-eosin staining. Arrows indicate nucleus damage (block of nerve conduction, caused by the induced damage). Article: " Role of the nucleus tractus solitarii in the protection of pre-moxibustion on gastric mucosal lesions," by Liang Peng, Mi Liu, Xiaorong Chang, Zhou Yang, Shouxiang Yi, Jie Yan, Yan Peng (College of Acupuncture and Tuina, Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, China) Peng L, Liu M, Chang XR, Yang Z, Yi SX, Yan J, Peng Y. Role of the nucleus tractus solitarii in the protection of pre-moxibustion on gastric mucosal lesions. Neural Regen Res. 2014;9(2):198-204.