【doc】参考文献的重要性

【doc】参考文献的重要性 参考文献的重要性 ? 908?医学综述2010年3月第16卷第6期Medicalilu【eI丛堕:::? 尚未明了?.血管内皮细胞上也有IGF一1受体,因 而推测IGF一1受体与糖尿病微血管并发症有关. IGF一1能使正常人,糖尿病患者,糖尿病肾病和中度 慢性肾功能不全患者的肾小球滤过率,.肾血流量以 及肌酐清除率增高.然而由于IGF-1半衰期短,且缺 乏合适的口服剂型,需多次反复静脉注射,给治疗带 来不便.另一方面,重组IGF.1价格昂贵,生产工艺 比较复杂,有效治疗剂量很大,目前尚缺少与天然 IGF一1生物学活性相近的基因工程产品,因此临床推 广存在一定难度].在国外,临床上已试用IGF一1 制剂治疗糖尿病,代谢性疾病,生殖官能不全症并 取得了良好的效果,但其疗效仍有待更多的临床实 践长期观察证实. 综上所述,IGF.1可以减少胰岛B细胞凋亡,促 进胰岛素分泌,对糖尿病并发症有一定作用.IGF一1 以其独特的生理功能,被认为是治疗糖尿病最有前 途的新型药物之一,值得进行深入的基础研究及临 床实验. 参考文献 [1]TattersallAL,WilkinsRJ.ModulationofNa一Hexchangeis0一 formsNHE1andNHE3byinsulin-?likegrowthfactor--1inisolated bovinearticularchondrocytes[J].JOrthopRes,2008,26(11): 1428.1433. [2]Kamanga—SolloE,WhiteME,HathawayMR,eta1.RolesofIGF—I andtheestrogen,androgenandIGF—Ireceptorsinestradiol一17beta- andtrenboloneacetate—stimulatedproliferationofculturedbovine satellitecells[J].DomestAnimEndocrinol,2008,35(1):88-97. [3]FolsomAR,KushiLH,AndersonKE,eta1.Associationsofgeneral andabdominalobesitywithmultiplehealthoutcomesinolder women:theIowaWomensHealthStudy[J].ArchInternMed, 2000,160(14):2117-2128. [4]ChowWH,GridleyG,FraumeniJF,et?z.Obesity,hypertension, andtheriskofkidneycancerinmen[J].NEnglJMed,2000,343 (18):1305-1311.. [5]TassoneF,ProcopioM,GianottiL,eta1.Insulinresistanceisnot coupledwithdefectiveinsulinsecretioninprimaryhyperparathy- roidism[J].DiabetMed,2009,26(10):968073. [6]YakarS,LiuJL,FemandezAM,eta1.LiverspecificIGF一1gene deletionleadstomuscleinsulininsensitivity[J].Diabetes,2001, 5O(5):1110—1118. [7]SestiG,SciacquaA,CardelliniM,eta1.Plasmaconcentrationof IGF—Iisindependentlyassociatedwithinsulinsensitivityinsub— jectswithdifferentdegreesofglucosetolerance[J].DiabetesCare, 2005,28(1):120-125. [8]YazdanpanabM,Sayed—TabatabaeiFA,JanssenJA,eta1.IGF.I genepromoterpolynmrphismisapredictorofsurvivalaftermyocar- dialinfarctioninpatientswithtype2diabetes[J].EurJEndocri- nol,2006,155(5):751-756. [9]MuzumdarRH,Max,FishmanS,eta1.Centralandopposing effectsofIGF—IandIGF—bindingprotein-3onsystemicinsulinac- tion[J].Diabetes,2006,55(10):2788-2796. [10]GrottoliS,GascoV,MainolfiA,eta1.Growthhormone/insulin- likegrowthfactorIaxis,glucosemetabolism,andlypolisisbut notleptinshowsomedegreeofrefrac~rinesstoshort—termfasting inacromegaly[J].JEndoerinolInvest,2008,31(12): 11O3一l109. [11]YakarS,SetserJ,ZhaoH,eta1.Inhibitionofgrowthhormone8c? tionimprovesinsulinsensitivityinliverIGF.1deficientmice[J].J ClinInvest,2004,113(1):96—105. [12]SimpsonHL,JacksonNC,ShojaeeM,eta1.IGF一1hasadirect effectonglucoseandproteinmetabolism,butnoeffectonlipidme- tabolismintype1diabetes[J].JClinEndoefinolMetab,2004,89 (1):425-432. [13]L6pez—BermejoA,KhosraviJ,Ferndndez?RealJM,eta1.Insulinre— sistaneeisassociatedwithincreasedserumconcentrationofIGF- bindingprotein—relatedprotein1(IGFBP—rP1/MAC25)[J].Dia- betes,2006,55(8):2333-2339. 『14]SestiG,FedericiM,LauroD,eta1.Molecularmechanismofinsulin [15] [16] [17] [18] [19] [2O] [21] resistanceintype2diabetesmellitus:roleoftheinsulinreceptor variantforms[J].DiabetesMetabResRev,2001,17(5): 363.373. RajpathakSN,GunterMJ,Wylie-RosettJ,ela1.Theroleofinsulin— likegrowthfactor—Ianditsbindingproteinsinglucosehomeosta- sisandtype2diabetes[J].DiabetesMetabResRev,2009,25 (1):3—12. SandhuMS,HealdAH,GibsonJM,etq1.Circulatingconcentrations ofinsulin—likegrowthfactor-1anddevelopmentofglucoseintoler; ance:aprospectiveobservationalstudy[J].Lancet,2002,359 (9519):1740-1745. RosenbloomAL.Mecaserminrecombinanthumaninsulin—like growthfactorI[J].AdvTher,2009,26(1):4O_54. ClemmonsDR,SleeviM,AllanG,eta1.Effectsofcombinedreeom? binantinsulin-likegrowthfactor(IGF)-IandIGFbindingpro- tein-3intype2diabeticpatientsonglycemiecontrolanddistribu- tionofIGF—IandIGF—I1amongserumbindingproteincomplexes [J].JClinEndocrinolMetab,2007,92(7):2652-2658. 尹国平,陈丽.神经营养因子与糖尿病脑病[J].国际内分泌代 谢杂志,2006,26(2):119—122. 段宁,周红文,汪承亚,等.胰岛素样生长因子-1基因达对糖 尿病大鼠血糖的影响[J].南京医科大学,2004,24(4): 317.320. HayesVY,UrbanRJ,JiangJ,eta1.Recombinanthumangrowth hormoneandrecombinanthumaninsulin?likegrowthfactorIdi- minishthecataboliceffectsofhypogonadisminman:metabolicand moleculareffects[J].JClinEndoerinolMetab,2001,86(5): 221l-2219. 收稿日期:2009-09—13修回13期:2010-01—10